The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells

WNT/β-catenin signaling is an essential regulator of many developmental processes. Here, the authors provide evidence that activation of the WNT in human pluripotent stem cells leads to expression WNT target gene SP5, which then acts to diminish expression of active WNT target genes.

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Autores principales:	Ian J. Huggins, Tomas Bos, Olivia Gaylord, Christina Jessen, Brianna Lonquich, Angeline Puranen, Jenna Richter, Charlotte Rossdam, David Brafman, Terry Gaasterland, Karl Willert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7264afb5c1c3408ea9b76760065ca559
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spelling	oai:doaj.org-article:7264afb5c1c3408ea9b76760065ca5592021-12-02T15:38:45ZThe WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells10.1038/s41467-017-01203-12041-1723https://doaj.org/article/7264afb5c1c3408ea9b76760065ca5592017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01203-1https://doaj.org/toc/2041-1723WNT/β-catenin signaling is an essential regulator of many developmental processes. Here, the authors provide evidence that activation of the WNT in human pluripotent stem cells leads to expression WNT target gene SP5, which then acts to diminish expression of active WNT target genes.Ian J. HugginsTomas BosOlivia GaylordChristina JessenBrianna LonquichAngeline PuranenJenna RichterCharlotte RossdamDavid BrafmanTerry GaasterlandKarl WillertNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ian J. Huggins Tomas Bos Olivia Gaylord Christina Jessen Brianna Lonquich Angeline Puranen Jenna Richter Charlotte Rossdam David Brafman Terry Gaasterland Karl Willert The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells
description	WNT/β-catenin signaling is an essential regulator of many developmental processes. Here, the authors provide evidence that activation of the WNT in human pluripotent stem cells leads to expression WNT target gene SP5, which then acts to diminish expression of active WNT target genes.
format	article
author	Ian J. Huggins Tomas Bos Olivia Gaylord Christina Jessen Brianna Lonquich Angeline Puranen Jenna Richter Charlotte Rossdam David Brafman Terry Gaasterland Karl Willert
author_facet	Ian J. Huggins Tomas Bos Olivia Gaylord Christina Jessen Brianna Lonquich Angeline Puranen Jenna Richter Charlotte Rossdam David Brafman Terry Gaasterland Karl Willert
author_sort	Ian J. Huggins
title	The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells
title_short	The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells
title_full	The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells
title_fullStr	The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells
title_full_unstemmed	The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells
title_sort	wnt target sp5 negatively regulates wnt transcriptional programs in human pluripotent stem cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7264afb5c1c3408ea9b76760065ca559
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The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells

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