Mobilization of progenitor cells and vessel healing after implantation of SYNERGY in acute coronary syndrome

Abstract This study was aimed to compare the vascular healing process of a SYNERGY stent with that of a PROMUS PREMIER stent in patients with acute coronary syndrome (ACS). In 71 patients with ACS, undergoing coronary stent implantation using the SYNERGY stent (n = 52) or PROMUS PREMIER stent (n = 1...

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Autores principales:	Masashi Sakuma, Setsu Nishino, Takahisa Nasuno, Michiya Kageyama, Michiaki Tokura, Ryoichi Sohma, Ken-ichi Inoue, Tomoaki Kanaya, Syotaro Obi, Shigeru Toyoda, Shichiro Abe, Guiherme F. Attizzani, Gabriel T. R. Pereira, Hiram G. Bezerra, Teruo Inoue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/726631f212c1473cbe22e5f119b7d5db
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spelling	oai:doaj.org-article:726631f212c1473cbe22e5f119b7d5db2021-12-02T19:02:27ZMobilization of progenitor cells and vessel healing after implantation of SYNERGY in acute coronary syndrome10.1038/s41598-021-96730-92045-2322https://doaj.org/article/726631f212c1473cbe22e5f119b7d5db2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96730-9https://doaj.org/toc/2045-2322Abstract This study was aimed to compare the vascular healing process of a SYNERGY stent with that of a PROMUS PREMIER stent in patients with acute coronary syndrome (ACS). In 71 patients with ACS, undergoing coronary stent implantation using the SYNERGY stent (n = 52) or PROMUS PREMIER stent (n = 19), we measured circulating CD34+/CD133+/CD45null cells and CD34+/KDR+ cells and observed vascular healing at the stented sites using optical coherence tomography (OCT) and coronary angioscopy. On the day 7, circulating CD34+/CD133+/CD45null cells increased in SYNERGY group (P < 0.0001), while it did not change in PROMUS group. The CD34+/KDR+ cells also increased in SYNERGY group (P < 0.0001) but less significantly in the PROMUS group (P < 0.05). The OCT-based neointimal thickness (P < 0.0005) and neointimal coverage rate (P < 0.05) at 12 months were greater in SYNERGY group, compared with PROMUS group. The coronary angioscopy-based neointimal coverage grade at 12 months was also greater in SYNERGY group (P < 0.001). In overall patients, the change in CD34+/KDR+ cells on the day 7 correlated with the OCT-based neointimal thickness at 12 months (R = 0.288, P < 0.05). SYNERGY stent seems to have potential advantages over PROMUS PREMIER stent for ACS patients in terms of vascular healing process at the stented sites.Masashi SakumaSetsu NishinoTakahisa NasunoMichiya KageyamaMichiaki TokuraRyoichi SohmaKen-ichi InoueTomoaki KanayaSyotaro ObiShigeru ToyodaShichiro AbeGuiherme F. AttizzaniGabriel T. R. PereiraHiram G. BezerraTeruo InoueNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masashi Sakuma Setsu Nishino Takahisa Nasuno Michiya Kageyama Michiaki Tokura Ryoichi Sohma Ken-ichi Inoue Tomoaki Kanaya Syotaro Obi Shigeru Toyoda Shichiro Abe Guiherme F. Attizzani Gabriel T. R. Pereira Hiram G. Bezerra Teruo Inoue Mobilization of progenitor cells and vessel healing after implantation of SYNERGY in acute coronary syndrome
description	Abstract This study was aimed to compare the vascular healing process of a SYNERGY stent with that of a PROMUS PREMIER stent in patients with acute coronary syndrome (ACS). In 71 patients with ACS, undergoing coronary stent implantation using the SYNERGY stent (n = 52) or PROMUS PREMIER stent (n = 19), we measured circulating CD34+/CD133+/CD45null cells and CD34+/KDR+ cells and observed vascular healing at the stented sites using optical coherence tomography (OCT) and coronary angioscopy. On the day 7, circulating CD34+/CD133+/CD45null cells increased in SYNERGY group (P < 0.0001), while it did not change in PROMUS group. The CD34+/KDR+ cells also increased in SYNERGY group (P < 0.0001) but less significantly in the PROMUS group (P < 0.05). The OCT-based neointimal thickness (P < 0.0005) and neointimal coverage rate (P < 0.05) at 12 months were greater in SYNERGY group, compared with PROMUS group. The coronary angioscopy-based neointimal coverage grade at 12 months was also greater in SYNERGY group (P < 0.001). In overall patients, the change in CD34+/KDR+ cells on the day 7 correlated with the OCT-based neointimal thickness at 12 months (R = 0.288, P < 0.05). SYNERGY stent seems to have potential advantages over PROMUS PREMIER stent for ACS patients in terms of vascular healing process at the stented sites.
format	article
author	Masashi Sakuma Setsu Nishino Takahisa Nasuno Michiya Kageyama Michiaki Tokura Ryoichi Sohma Ken-ichi Inoue Tomoaki Kanaya Syotaro Obi Shigeru Toyoda Shichiro Abe Guiherme F. Attizzani Gabriel T. R. Pereira Hiram G. Bezerra Teruo Inoue
author_facet	Masashi Sakuma Setsu Nishino Takahisa Nasuno Michiya Kageyama Michiaki Tokura Ryoichi Sohma Ken-ichi Inoue Tomoaki Kanaya Syotaro Obi Shigeru Toyoda Shichiro Abe Guiherme F. Attizzani Gabriel T. R. Pereira Hiram G. Bezerra Teruo Inoue
author_sort	Masashi Sakuma
title	Mobilization of progenitor cells and vessel healing after implantation of SYNERGY in acute coronary syndrome
title_short	Mobilization of progenitor cells and vessel healing after implantation of SYNERGY in acute coronary syndrome
title_full	Mobilization of progenitor cells and vessel healing after implantation of SYNERGY in acute coronary syndrome
title_fullStr	Mobilization of progenitor cells and vessel healing after implantation of SYNERGY in acute coronary syndrome
title_full_unstemmed	Mobilization of progenitor cells and vessel healing after implantation of SYNERGY in acute coronary syndrome
title_sort	mobilization of progenitor cells and vessel healing after implantation of synergy in acute coronary syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/726631f212c1473cbe22e5f119b7d5db
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Mobilization of progenitor cells and vessel healing after implantation of SYNERGY in acute coronary syndrome

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