The Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies

Xuemeng Dong,1 Zehao Wu,1 Xiuping Li,1 Liyan Xiao,1 Man Yang,1,2 Yang Li,1,2 Junchao Duan,1,2 Zhiwei Sun1,2 1School of Public Health, Capital Medical University, Beijing 100069, People’s Republic of China; 2Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Bei...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dong X, Wu Z, Li X, Xiao L, Yang M, Li Y, Duan J, Sun Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	silica nanoparticles particle size cytotoxicity cell death nanotoxicology influence factors Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/72668b18f9a34f95bb5fb6354736f901
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:72668b18f9a34f95bb5fb6354736f901
record_format	dspace
spelling	oai:doaj.org-article:72668b18f9a34f95bb5fb6354736f9012021-12-02T12:26:50ZThe Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies1178-2013https://doaj.org/article/72668b18f9a34f95bb5fb6354736f9012020-11-01T00:00:00Zhttps://www.dovepress.com/the-size-dependent-cytotoxicity-of-amorphous-silica-nanoparticles-a-sy-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xuemeng Dong,1 Zehao Wu,1 Xiuping Li,1 Liyan Xiao,1 Man Yang,1,2 Yang Li,1,2 Junchao Duan,1,2 Zhiwei Sun1,2 1School of Public Health, Capital Medical University, Beijing 100069, People’s Republic of China; 2Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, People’s Republic of ChinaCorrespondence: Zhiwei Sun; Yang LiBeijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, People’s Republic of ChinaTel/Fax +86 010 83911507; +86 010 83911868Email zwsun@ccmu.edu.cn; li_yang@ccmu.edu.cnAbstract: With the increasing production and application of engineered amorphous silica nanoparticles (aSiNPs), people have more opportunities to be exposed to aSiNPs. However, the knowledge of its adverse health effects and related mechanisms is still limited, compared with the well-studied crystalline micron-sized silica. Since small differences in the physical–chemical properties of nanoparticles could cause significant differences in the toxic effect, it is important to distinguish how these variations influence the outcoming toxicity. Notably, particle size, as one of the essential characterizations of aSiNPs, is relevant to its biological activities. Thus, the aim of this systematic review was to summarize the relationship between the particle size of aSiNPs and its adverse biological effects. In order to avoid the influence of complicated in vivo experimental conditions on the toxic outcome, only in vitro toxicity studies which reported on the cytotoxic effect of different sizes aSiNPs were included. After the systematic literature retrieval, selection, and quality assessment process, 76 eligible scientific papers were finally included in this review. There were 76% of the studies that concluded a size-dependent cytotoxicity of aSiNPs, in which smaller-sized aSiNPs possessed greater toxicity. However, this trend could be modified by certain influence factors, such as the synthetic method of aSiNPs, particle aggregation state in cell culture medium, toxicity endpoint detection method, and some other experimental conditions. The effects of these influence factors on the size-dependent cytotoxicity of aSiNPs were also discussed in detail in the present review.Keywords: silica nanoparticles, particle size, cytotoxicity, cell death, nanotoxicology, influence factorsDong XWu ZLi XXiao LYang MLi YDuan JSun ZDove Medical Pressarticlesilica nanoparticlesparticle sizecytotoxicitycell deathnanotoxicologyinfluence factorsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 9089-9113 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	silica nanoparticles particle size cytotoxicity cell death nanotoxicology influence factors Medicine (General) R5-920
spellingShingle	silica nanoparticles particle size cytotoxicity cell death nanotoxicology influence factors Medicine (General) R5-920 Dong X Wu Z Li X Xiao L Yang M Li Y Duan J Sun Z The Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies
description	Xuemeng Dong,1 Zehao Wu,1 Xiuping Li,1 Liyan Xiao,1 Man Yang,1,2 Yang Li,1,2 Junchao Duan,1,2 Zhiwei Sun1,2 1School of Public Health, Capital Medical University, Beijing 100069, People’s Republic of China; 2Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, People’s Republic of ChinaCorrespondence: Zhiwei Sun; Yang LiBeijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, People’s Republic of ChinaTel/Fax +86 010 83911507; +86 010 83911868Email zwsun@ccmu.edu.cn; li_yang@ccmu.edu.cnAbstract: With the increasing production and application of engineered amorphous silica nanoparticles (aSiNPs), people have more opportunities to be exposed to aSiNPs. However, the knowledge of its adverse health effects and related mechanisms is still limited, compared with the well-studied crystalline micron-sized silica. Since small differences in the physical–chemical properties of nanoparticles could cause significant differences in the toxic effect, it is important to distinguish how these variations influence the outcoming toxicity. Notably, particle size, as one of the essential characterizations of aSiNPs, is relevant to its biological activities. Thus, the aim of this systematic review was to summarize the relationship between the particle size of aSiNPs and its adverse biological effects. In order to avoid the influence of complicated in vivo experimental conditions on the toxic outcome, only in vitro toxicity studies which reported on the cytotoxic effect of different sizes aSiNPs were included. After the systematic literature retrieval, selection, and quality assessment process, 76 eligible scientific papers were finally included in this review. There were 76% of the studies that concluded a size-dependent cytotoxicity of aSiNPs, in which smaller-sized aSiNPs possessed greater toxicity. However, this trend could be modified by certain influence factors, such as the synthetic method of aSiNPs, particle aggregation state in cell culture medium, toxicity endpoint detection method, and some other experimental conditions. The effects of these influence factors on the size-dependent cytotoxicity of aSiNPs were also discussed in detail in the present review.Keywords: silica nanoparticles, particle size, cytotoxicity, cell death, nanotoxicology, influence factors
format	article
author	Dong X Wu Z Li X Xiao L Yang M Li Y Duan J Sun Z
author_facet	Dong X Wu Z Li X Xiao L Yang M Li Y Duan J Sun Z
author_sort	Dong X
title	The Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies
title_short	The Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies
title_full	The Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies
title_fullStr	The Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies
title_full_unstemmed	The Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies
title_sort	size-dependent cytotoxicity of amorphous silica nanoparticles: a systematic review of in vitro studies
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/72668b18f9a34f95bb5fb6354736f901
work_keys_str_mv	AT dongx thesizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT wuz thesizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT lix thesizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT xiaol thesizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT yangm thesizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT liy thesizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT duanj thesizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT sunz thesizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT dongx sizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT wuz sizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT lix sizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT xiaol sizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT yangm sizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT liy sizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT duanj sizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies AT sunz sizedependentcytotoxicityofamorphoussilicananoparticlesasystematicreviewofinvitrostudies
_version_	1718394459959328768

The Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies

Ejemplares similares