Prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis

Abstract To examine whether hypermetabolism could predict the prognosis of early amyotrophic lateral sclerosis (ALS) patients with differing nutritional profiles. This single-center, retrospective study examined the prognosis of ALS patients with hypermetabolism in relation to their nutritional stat...

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Autores principales:	Ryutaro Nakamura, Mika Kurihara, Nobuhiro Ogawa, Akihiro Kitamura, Isamu Yamakawa, Shigeki Bamba, Mitsuru Sanada, Masaya Sasaki, Makoto Urushitani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/726f155e54d34f88b6c99e7661915b55
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spelling	oai:doaj.org-article:726f155e54d34f88b6c99e7661915b552021-12-02T17:19:17ZPrognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis10.1038/s41598-021-97196-52045-2322https://doaj.org/article/726f155e54d34f88b6c99e7661915b552021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97196-5https://doaj.org/toc/2045-2322Abstract To examine whether hypermetabolism could predict the prognosis of early amyotrophic lateral sclerosis (ALS) patients with differing nutritional profiles. This single-center, retrospective study examined the prognosis of ALS patients with hypermetabolism in relation to their nutritional status at hospitalization. The metabolic state was estimated by the ratio of measured resting energy expenditure (mREE) to lean soft tissue mass (LSTM) (mREE/LSTM), wherein patients with ratios ≥ 38 were defined as hypermetabolic. Malnutrition was defined as %ideal body weight < 0.9. Forty-eight patients were enrolled in this study. The hypermetabolic group had shorter survival in the normal-weight group but more prolonged survival in the malnutrition group. Multiplication of nutritional and metabolic factors, such as [(body mass index (BMI) − 19.8) × (mREE/LSTM − 38)], designated as BMI-muscle metabolism index (BMM index), successfully predicted the prognosis in the group with a high BMM index (≥ 1), which showed shorter survival and a faster rate of weight loss and functional decline. Multivariate analysis using the Cox model showed high BMM index was an independent poor prognostic factor (hazard ratio: 4.05; p = 0.025). Prognostic prediction by hypermetabolism varies depending on the nutritional status in ALS, and the BMM index is a consistent prognostic factor.Ryutaro NakamuraMika KuriharaNobuhiro OgawaAkihiro KitamuraIsamu YamakawaShigeki BambaMitsuru SanadaMasaya SasakiMakoto UrushitaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ryutaro Nakamura Mika Kurihara Nobuhiro Ogawa Akihiro Kitamura Isamu Yamakawa Shigeki Bamba Mitsuru Sanada Masaya Sasaki Makoto Urushitani Prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis
description	Abstract To examine whether hypermetabolism could predict the prognosis of early amyotrophic lateral sclerosis (ALS) patients with differing nutritional profiles. This single-center, retrospective study examined the prognosis of ALS patients with hypermetabolism in relation to their nutritional status at hospitalization. The metabolic state was estimated by the ratio of measured resting energy expenditure (mREE) to lean soft tissue mass (LSTM) (mREE/LSTM), wherein patients with ratios ≥ 38 were defined as hypermetabolic. Malnutrition was defined as %ideal body weight < 0.9. Forty-eight patients were enrolled in this study. The hypermetabolic group had shorter survival in the normal-weight group but more prolonged survival in the malnutrition group. Multiplication of nutritional and metabolic factors, such as [(body mass index (BMI) − 19.8) × (mREE/LSTM − 38)], designated as BMI-muscle metabolism index (BMM index), successfully predicted the prognosis in the group with a high BMM index (≥ 1), which showed shorter survival and a faster rate of weight loss and functional decline. Multivariate analysis using the Cox model showed high BMM index was an independent poor prognostic factor (hazard ratio: 4.05; p = 0.025). Prognostic prediction by hypermetabolism varies depending on the nutritional status in ALS, and the BMM index is a consistent prognostic factor.
format	article
author	Ryutaro Nakamura Mika Kurihara Nobuhiro Ogawa Akihiro Kitamura Isamu Yamakawa Shigeki Bamba Mitsuru Sanada Masaya Sasaki Makoto Urushitani
author_facet	Ryutaro Nakamura Mika Kurihara Nobuhiro Ogawa Akihiro Kitamura Isamu Yamakawa Shigeki Bamba Mitsuru Sanada Masaya Sasaki Makoto Urushitani
author_sort	Ryutaro Nakamura
title	Prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis
title_short	Prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis
title_full	Prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis
title_fullStr	Prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis
title_full_unstemmed	Prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis
title_sort	prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/726f155e54d34f88b6c99e7661915b55
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Prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis

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