A novel electrocardiographic index for the diagnosis of diastolic dysfunction.
<h4>Background</h4>Although the assessment of diastolic dysfunction (DD) is an integral part of routine cardiologic examinations, little is known about associated electrocardiographic (ECG) changes. Our aim was to investigate a potential role of ECG indices for the recognition of patient...
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2013
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oai:doaj.org-article:727165ec93f445be86d570884cd4056f2021-11-18T08:48:19ZA novel electrocardiographic index for the diagnosis of diastolic dysfunction.1932-620310.1371/journal.pone.0079152https://doaj.org/article/727165ec93f445be86d570884cd4056f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223898/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Although the assessment of diastolic dysfunction (DD) is an integral part of routine cardiologic examinations, little is known about associated electrocardiographic (ECG) changes. Our aim was to investigate a potential role of ECG indices for the recognition of patients with DD.<h4>Methods and results</h4>ECG parameters correlating with echocardiographic findings of DD were retrospectively assessed in a derivation group of 172 individuals (83 controls with normal diastolic function, 89 patients with DD) and their diagnostic performance was tested in a validation group of 50 controls and 50 patients. The patient group with a DD Grade 1 and 2 showed longer QTc (422 ± 24 ms and 434 ± 32 ms vs. 409 ± 25ms, p<0.0005) and shorter Tend-P and Tend-Q intervals, reflecting the electrical and mechanical diastole (240 ± 78 ms and 276 ± 108 ms vs. 373 ± 110 ms, p<0.0001; 409 ± 85 ms and 447 ± 115 ms vs. 526 ± 119 ms, p<0.0001). The PQ-interval was significantly longer in the patient group (169 ± 28ms and 171 ± 38ms vs. 153 ± 22ms, p<0.005). After adjusting for possible confounders, a novel index (Tend-P/[PQxAge]) showed a high performance for the recognition of DD, stayed robust in the validation group (sensitivity 82%, specificity 93%, positive predictive value 93%, negative predictive value 82%, accuracy 88%) and proved a substantial added value when combined with the indexed left atrial volume (LAESVI, sensitivity 90%, specificity 92%, positive predictive value 95%, negative predictive value 86%, accuracy 91%).<h4>Conclusions</h4>A novel electrocardiographic index Tend-P/(PQxAge) demonstrates a high diagnostic accuracy for the diagnosis of DD and yields a substantial added value when combined with the LAESVI.Mehdi NamdarPatric BiaggiBarbara StähliBernhard BütlerRubén Casado-ArroyoDanilo RicciardiMoisés Rodríguez-MañeroJan SteffelDavid HürlimannChristian SchmiedCarlo de AsmundisGian-Battista ChierchiaAndrea SarkozyThomas F LüscherRolf JenniFirat DuruWalter J PaulusPedro BrugadaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79152 (2013) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Mehdi Namdar Patric Biaggi Barbara Stähli Bernhard Bütler Rubén Casado-Arroyo Danilo Ricciardi Moisés Rodríguez-Mañero Jan Steffel David Hürlimann Christian Schmied Carlo de Asmundis Gian-Battista Chierchia Andrea Sarkozy Thomas F Lüscher Rolf Jenni Firat Duru Walter J Paulus Pedro Brugada A novel electrocardiographic index for the diagnosis of diastolic dysfunction. |
| description |
<h4>Background</h4>Although the assessment of diastolic dysfunction (DD) is an integral part of routine cardiologic examinations, little is known about associated electrocardiographic (ECG) changes. Our aim was to investigate a potential role of ECG indices for the recognition of patients with DD.<h4>Methods and results</h4>ECG parameters correlating with echocardiographic findings of DD were retrospectively assessed in a derivation group of 172 individuals (83 controls with normal diastolic function, 89 patients with DD) and their diagnostic performance was tested in a validation group of 50 controls and 50 patients. The patient group with a DD Grade 1 and 2 showed longer QTc (422 ± 24 ms and 434 ± 32 ms vs. 409 ± 25ms, p<0.0005) and shorter Tend-P and Tend-Q intervals, reflecting the electrical and mechanical diastole (240 ± 78 ms and 276 ± 108 ms vs. 373 ± 110 ms, p<0.0001; 409 ± 85 ms and 447 ± 115 ms vs. 526 ± 119 ms, p<0.0001). The PQ-interval was significantly longer in the patient group (169 ± 28ms and 171 ± 38ms vs. 153 ± 22ms, p<0.005). After adjusting for possible confounders, a novel index (Tend-P/[PQxAge]) showed a high performance for the recognition of DD, stayed robust in the validation group (sensitivity 82%, specificity 93%, positive predictive value 93%, negative predictive value 82%, accuracy 88%) and proved a substantial added value when combined with the indexed left atrial volume (LAESVI, sensitivity 90%, specificity 92%, positive predictive value 95%, negative predictive value 86%, accuracy 91%).<h4>Conclusions</h4>A novel electrocardiographic index Tend-P/(PQxAge) demonstrates a high diagnostic accuracy for the diagnosis of DD and yields a substantial added value when combined with the LAESVI. |
| format |
article |
| author |
Mehdi Namdar Patric Biaggi Barbara Stähli Bernhard Bütler Rubén Casado-Arroyo Danilo Ricciardi Moisés Rodríguez-Mañero Jan Steffel David Hürlimann Christian Schmied Carlo de Asmundis Gian-Battista Chierchia Andrea Sarkozy Thomas F Lüscher Rolf Jenni Firat Duru Walter J Paulus Pedro Brugada |
| author_facet |
Mehdi Namdar Patric Biaggi Barbara Stähli Bernhard Bütler Rubén Casado-Arroyo Danilo Ricciardi Moisés Rodríguez-Mañero Jan Steffel David Hürlimann Christian Schmied Carlo de Asmundis Gian-Battista Chierchia Andrea Sarkozy Thomas F Lüscher Rolf Jenni Firat Duru Walter J Paulus Pedro Brugada |
| author_sort |
Mehdi Namdar |
| title |
A novel electrocardiographic index for the diagnosis of diastolic dysfunction. |
| title_short |
A novel electrocardiographic index for the diagnosis of diastolic dysfunction. |
| title_full |
A novel electrocardiographic index for the diagnosis of diastolic dysfunction. |
| title_fullStr |
A novel electrocardiographic index for the diagnosis of diastolic dysfunction. |
| title_full_unstemmed |
A novel electrocardiographic index for the diagnosis of diastolic dysfunction. |
| title_sort |
novel electrocardiographic index for the diagnosis of diastolic dysfunction. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/727165ec93f445be86d570884cd4056f |
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