Recent advances in the local antibiotics delivery systems for management of osteomyelitis

Chronic osteomyelitis is a challenging disease due to its serious rates of mortality and morbidity while the currently available treatment strategies are suboptimal. In contrast to the adopted systemic treatment approaches after surgical debridement in chronic osteomyelitis, local drug delivery syst...

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Autores principales:	Reem Khaled Wassif, Maha Elkayal, Rehab Nabil Shamma, Seham A. Elkheshen
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	osteomyelitis bone scaffolds tissue engineering nanoparticles 3 d printing bone grafts local drug delivery Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/7273758576734093bacf1ca5b432283b
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spelling	oai:doaj.org-article:7273758576734093bacf1ca5b432283b2021-11-11T14:23:41ZRecent advances in the local antibiotics delivery systems for management of osteomyelitis1071-75441521-046410.1080/10717544.2021.1998246https://doaj.org/article/7273758576734093bacf1ca5b432283b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/10717544.2021.1998246https://doaj.org/toc/1071-7544https://doaj.org/toc/1521-0464Chronic osteomyelitis is a challenging disease due to its serious rates of mortality and morbidity while the currently available treatment strategies are suboptimal. In contrast to the adopted systemic treatment approaches after surgical debridement in chronic osteomyelitis, local drug delivery systems are receiving great attention in the recent decades. Local drug delivery systems using special carriers have the pros of enhancing the feasibility of penetration of antimicrobial agents to bone tissues, providing sustained release and localized concentrations of the antimicrobial agents in the infected area while avoiding the systemic side effects and toxicity. Most important, the incorporation of osteoinductive and osteoconductive materials in these systems assists bones proliferation and differentiation, hence the generation of new bone materials is enhanced. Some of these systems can also provide mechanical support for the long bones during the healing process. Most important, if the local systems are designed to be injectable to the affected site and biodegradable, they will reduce the level of invasion required for implantation and can win the patients’ compliance and reduce the healing period. They will also allow multiple injections during the course of therapy to guard against the side effect of the long-term systemic therapy. The current review presents different available approaches for delivering antimicrobial agents for the treatment of osteomyelitis focusing on the recent advances in researches for local delivery of antibiotics.HIGHLIGHTS Chronic osteomyelitis is a challenging disease due to its serious mortality and morbidity rates and limited effective treatment options. Local drug delivery systems are receiving great attention in the recent decades. Osteoinductive and osteoconductive materials in the local systems assists bones proliferation and differentiation Local systems can be designed to provide mechanical support for the long bones during the healing process. Designing the local system to be injectable to the affected site and biodegradable will reduces the level of invasion and win the patients’ compliance.Reem Khaled WassifMaha ElkayalRehab Nabil ShammaSeham A. ElkheshenTaylor & Francis Grouparticleosteomyelitisbone scaffoldstissue engineeringnanoparticles3 d printingbone graftslocal drug deliveryTherapeutics. PharmacologyRM1-950ENDrug Delivery, Vol 28, Iss 1, Pp 2392-2414 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteomyelitis bone scaffolds tissue engineering nanoparticles 3 d printing bone grafts local drug delivery Therapeutics. Pharmacology RM1-950
spellingShingle	osteomyelitis bone scaffolds tissue engineering nanoparticles 3 d printing bone grafts local drug delivery Therapeutics. Pharmacology RM1-950 Reem Khaled Wassif Maha Elkayal Rehab Nabil Shamma Seham A. Elkheshen Recent advances in the local antibiotics delivery systems for management of osteomyelitis
description	Chronic osteomyelitis is a challenging disease due to its serious rates of mortality and morbidity while the currently available treatment strategies are suboptimal. In contrast to the adopted systemic treatment approaches after surgical debridement in chronic osteomyelitis, local drug delivery systems are receiving great attention in the recent decades. Local drug delivery systems using special carriers have the pros of enhancing the feasibility of penetration of antimicrobial agents to bone tissues, providing sustained release and localized concentrations of the antimicrobial agents in the infected area while avoiding the systemic side effects and toxicity. Most important, the incorporation of osteoinductive and osteoconductive materials in these systems assists bones proliferation and differentiation, hence the generation of new bone materials is enhanced. Some of these systems can also provide mechanical support for the long bones during the healing process. Most important, if the local systems are designed to be injectable to the affected site and biodegradable, they will reduce the level of invasion required for implantation and can win the patients’ compliance and reduce the healing period. They will also allow multiple injections during the course of therapy to guard against the side effect of the long-term systemic therapy. The current review presents different available approaches for delivering antimicrobial agents for the treatment of osteomyelitis focusing on the recent advances in researches for local delivery of antibiotics.HIGHLIGHTS Chronic osteomyelitis is a challenging disease due to its serious mortality and morbidity rates and limited effective treatment options. Local drug delivery systems are receiving great attention in the recent decades. Osteoinductive and osteoconductive materials in the local systems assists bones proliferation and differentiation Local systems can be designed to provide mechanical support for the long bones during the healing process. Designing the local system to be injectable to the affected site and biodegradable will reduces the level of invasion and win the patients’ compliance.
format	article
author	Reem Khaled Wassif Maha Elkayal Rehab Nabil Shamma Seham A. Elkheshen
author_facet	Reem Khaled Wassif Maha Elkayal Rehab Nabil Shamma Seham A. Elkheshen
author_sort	Reem Khaled Wassif
title	Recent advances in the local antibiotics delivery systems for management of osteomyelitis
title_short	Recent advances in the local antibiotics delivery systems for management of osteomyelitis
title_full	Recent advances in the local antibiotics delivery systems for management of osteomyelitis
title_fullStr	Recent advances in the local antibiotics delivery systems for management of osteomyelitis
title_full_unstemmed	Recent advances in the local antibiotics delivery systems for management of osteomyelitis
title_sort	recent advances in the local antibiotics delivery systems for management of osteomyelitis
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/7273758576734093bacf1ca5b432283b
work_keys_str_mv	AT reemkhaledwassif recentadvancesinthelocalantibioticsdeliverysystemsformanagementofosteomyelitis AT mahaelkayal recentadvancesinthelocalantibioticsdeliverysystemsformanagementofosteomyelitis AT rehabnabilshamma recentadvancesinthelocalantibioticsdeliverysystemsformanagementofosteomyelitis AT sehamaelkheshen recentadvancesinthelocalantibioticsdeliverysystemsformanagementofosteomyelitis
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Recent advances in the local antibiotics delivery systems for management of osteomyelitis

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