Infiornativity lacrimal fluid interleukins in diagnostics and development of angle-closure glaucoma in elderly subjects

An increased percentage of the elderly subjects in pattern of contemporary society, along with other causes and risk factors, is accompanied by rise in the incidence of glaucoma. By 2020, according to international studies it is expected that prevalence of glaucoma patients in the world would increa...

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Autores principales:	A. M. Chukhraiev, N. M. Agarkov, D. A. Konyaev, E. V. Popova, M. M. Yablokov, A. S. Kulabukhov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	interleukins immunopathology angle-closure glaucoma elderly patients lacrimal fluid Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/7274a23b1bf84062ab8a7ebfcc567eba
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spelling	oai:doaj.org-article:7274a23b1bf84062ab8a7ebfcc567eba2021-11-22T07:09:55ZInfiornativity lacrimal fluid interleukins in diagnostics and development of angle-closure glaucoma in elderly subjects2220-76192313-739810.15789/2220-7619-IIT-1247https://doaj.org/article/7274a23b1bf84062ab8a7ebfcc567eba2020-11-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1247https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398An increased percentage of the elderly subjects in pattern of contemporary society, along with other causes and risk factors, is accompanied by rise in the incidence of glaucoma. By 2020, according to international studies it is expected that prevalence of glaucoma patients in the world would increase up to 80 million subjects. Among the elderly, glaucoma is a common pathology, which development is associated with local disturbances in interleukin profile. However, the features of the latter in patients with primary closed-angle glaucoma in the elderly were poorly examined. Studies of local interleukin status were conducted mainly in patients with suspected or initial manifestations of primary open-angle glaucoma. The features of lacrimal fluid interleukin shift in a target group of elderly patients suffering from stage II primary closed-angle glaucoma virtually gained no attention. In addition, a limited range of local interleukins in patients with such pathology in previous studies was examined. In addition, informativity of lacrimal fluid interleukins in elderly glaucoma patients was not assessed too based on objective methods. The aim of the current study was to outline features and informativity of local interleukin profile indicators in 58 elderly patients with primary closed-angle glaucoma stage II, aged 60—74 years (main group) and 27 age-matched elderly subjects lacking such pathology. The level of interleukins in the lacrimal fluid was determined with the enzyme immunoassay “Multiscan” analyzer (Finland) by using sandwich ELISA (R&D Diagnostic Inc., USA). Informativity of measuring various interleukins was calculated according to the generally accepted formula. It was found that local interleukin profile in elderly patients with primary closed-angle glaucoma was mainly featured with increased amount of IL-2, IL-17, IL-8, but decreased IL-10. Hence, such local interleukins displayed peak informativity. The data obtained should be used in the diagnostics and treatment of such pathology, as well as of applied importance to unveil novel mechanisms behind development, diagnostics and corroboration for selective immuno-tropic therapy of primary closed-angle glaucoma.A. M. ChukhraievN. M. AgarkovD. A. KonyaevE. V. PopovaM. M. YablokovA. S. KulabukhovSankt-Peterburg : NIIÈM imeni Pasteraarticleinterleukinsimmunopathologyangle-closure glaucomaelderly patientslacrimal fluidInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 10, Iss 4, Pp 755-761 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	interleukins immunopathology angle-closure glaucoma elderly patients lacrimal fluid Infectious and parasitic diseases RC109-216
spellingShingle	interleukins immunopathology angle-closure glaucoma elderly patients lacrimal fluid Infectious and parasitic diseases RC109-216 A. M. Chukhraiev N. M. Agarkov D. A. Konyaev E. V. Popova M. M. Yablokov A. S. Kulabukhov Infiornativity lacrimal fluid interleukins in diagnostics and development of angle-closure glaucoma in elderly subjects
description	An increased percentage of the elderly subjects in pattern of contemporary society, along with other causes and risk factors, is accompanied by rise in the incidence of glaucoma. By 2020, according to international studies it is expected that prevalence of glaucoma patients in the world would increase up to 80 million subjects. Among the elderly, glaucoma is a common pathology, which development is associated with local disturbances in interleukin profile. However, the features of the latter in patients with primary closed-angle glaucoma in the elderly were poorly examined. Studies of local interleukin status were conducted mainly in patients with suspected or initial manifestations of primary open-angle glaucoma. The features of lacrimal fluid interleukin shift in a target group of elderly patients suffering from stage II primary closed-angle glaucoma virtually gained no attention. In addition, a limited range of local interleukins in patients with such pathology in previous studies was examined. In addition, informativity of lacrimal fluid interleukins in elderly glaucoma patients was not assessed too based on objective methods. The aim of the current study was to outline features and informativity of local interleukin profile indicators in 58 elderly patients with primary closed-angle glaucoma stage II, aged 60—74 years (main group) and 27 age-matched elderly subjects lacking such pathology. The level of interleukins in the lacrimal fluid was determined with the enzyme immunoassay “Multiscan” analyzer (Finland) by using sandwich ELISA (R&D Diagnostic Inc., USA). Informativity of measuring various interleukins was calculated according to the generally accepted formula. It was found that local interleukin profile in elderly patients with primary closed-angle glaucoma was mainly featured with increased amount of IL-2, IL-17, IL-8, but decreased IL-10. Hence, such local interleukins displayed peak informativity. The data obtained should be used in the diagnostics and treatment of such pathology, as well as of applied importance to unveil novel mechanisms behind development, diagnostics and corroboration for selective immuno-tropic therapy of primary closed-angle glaucoma.
format	article
author	A. M. Chukhraiev N. M. Agarkov D. A. Konyaev E. V. Popova M. M. Yablokov A. S. Kulabukhov
author_facet	A. M. Chukhraiev N. M. Agarkov D. A. Konyaev E. V. Popova M. M. Yablokov A. S. Kulabukhov
author_sort	A. M. Chukhraiev
title	Infiornativity lacrimal fluid interleukins in diagnostics and development of angle-closure glaucoma in elderly subjects
title_short	Infiornativity lacrimal fluid interleukins in diagnostics and development of angle-closure glaucoma in elderly subjects
title_full	Infiornativity lacrimal fluid interleukins in diagnostics and development of angle-closure glaucoma in elderly subjects
title_fullStr	Infiornativity lacrimal fluid interleukins in diagnostics and development of angle-closure glaucoma in elderly subjects
title_full_unstemmed	Infiornativity lacrimal fluid interleukins in diagnostics and development of angle-closure glaucoma in elderly subjects
title_sort	infiornativity lacrimal fluid interleukins in diagnostics and development of angle-closure glaucoma in elderly subjects
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/7274a23b1bf84062ab8a7ebfcc567eba
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Infiornativity lacrimal fluid interleukins in diagnostics and development of angle-closure glaucoma in elderly subjects

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