Analysis and phylogeny of small heat shock proteins from marine viruses and their cyanobacteria host.

Small heat shock proteins (sHSPs) are oligomeric stress proteins characterized by an α-crystallin domain (ACD) surrounded by a N-terminal arm and C-terminal extension. Publications on sHSPs have reported that they exist in prokaryotes and eukaryotes but, to our knowledge, not in viruses. Here we sho...

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Autores principales:	Halim Maaroufi, Robert M Tanguay
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7276126dcc2447a7ba0a9887402f0c8c
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spelling	oai:doaj.org-article:7276126dcc2447a7ba0a9887402f0c8c2021-11-18T08:47:00ZAnalysis and phylogeny of small heat shock proteins from marine viruses and their cyanobacteria host.1932-620310.1371/journal.pone.0081207https://doaj.org/article/7276126dcc2447a7ba0a9887402f0c8c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24265841/?tool=EBIhttps://doaj.org/toc/1932-6203Small heat shock proteins (sHSPs) are oligomeric stress proteins characterized by an α-crystallin domain (ACD) surrounded by a N-terminal arm and C-terminal extension. Publications on sHSPs have reported that they exist in prokaryotes and eukaryotes but, to our knowledge, not in viruses. Here we show that sHSPs are present in some cyanophages that infect the marine unicellular cyanobacteria, Synechococcus and Prochlorococcus. These phage sHSPs contain a conserved ACD flanked by a relatively conserved N-terminal arm and a short C-terminal extension with or without the conserved C-terminal anchoring module (CAM) L-X-I/V, suggested to be implicated in the oligomerization. In addition, cyanophage sHSPs have the signature pattern, P-P-[YF]-N-[ILV]-[IV]-x(9)-[EQ], in the predicted β2 and β3 strands of the ACD. Phylogenetically, cyanophage sHSPs form a monophyletic clade closer to bacterial class A sHSPs than to cyanobacterial sHSPs. Furthermore, three sHSPs from their cellular host, Synechococcus, are phylogenetically close to plants sHSPs. Implications of evolutionary relationships between the sHSPs of cyanophages, bacterial class A, cyanobacteria, and plants are discussed.Halim MaaroufiRobert M TanguayPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e81207 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Halim Maaroufi Robert M Tanguay Analysis and phylogeny of small heat shock proteins from marine viruses and their cyanobacteria host.
description	Small heat shock proteins (sHSPs) are oligomeric stress proteins characterized by an α-crystallin domain (ACD) surrounded by a N-terminal arm and C-terminal extension. Publications on sHSPs have reported that they exist in prokaryotes and eukaryotes but, to our knowledge, not in viruses. Here we show that sHSPs are present in some cyanophages that infect the marine unicellular cyanobacteria, Synechococcus and Prochlorococcus. These phage sHSPs contain a conserved ACD flanked by a relatively conserved N-terminal arm and a short C-terminal extension with or without the conserved C-terminal anchoring module (CAM) L-X-I/V, suggested to be implicated in the oligomerization. In addition, cyanophage sHSPs have the signature pattern, P-P-[YF]-N-[ILV]-[IV]-x(9)-[EQ], in the predicted β2 and β3 strands of the ACD. Phylogenetically, cyanophage sHSPs form a monophyletic clade closer to bacterial class A sHSPs than to cyanobacterial sHSPs. Furthermore, three sHSPs from their cellular host, Synechococcus, are phylogenetically close to plants sHSPs. Implications of evolutionary relationships between the sHSPs of cyanophages, bacterial class A, cyanobacteria, and plants are discussed.
format	article
author	Halim Maaroufi Robert M Tanguay
author_facet	Halim Maaroufi Robert M Tanguay
author_sort	Halim Maaroufi
title	Analysis and phylogeny of small heat shock proteins from marine viruses and their cyanobacteria host.
title_short	Analysis and phylogeny of small heat shock proteins from marine viruses and their cyanobacteria host.
title_full	Analysis and phylogeny of small heat shock proteins from marine viruses and their cyanobacteria host.
title_fullStr	Analysis and phylogeny of small heat shock proteins from marine viruses and their cyanobacteria host.
title_full_unstemmed	Analysis and phylogeny of small heat shock proteins from marine viruses and their cyanobacteria host.
title_sort	analysis and phylogeny of small heat shock proteins from marine viruses and their cyanobacteria host.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7276126dcc2447a7ba0a9887402f0c8c
work_keys_str_mv	AT halimmaaroufi analysisandphylogenyofsmallheatshockproteinsfrommarinevirusesandtheircyanobacteriahost AT robertmtanguay analysisandphylogenyofsmallheatshockproteinsfrommarinevirusesandtheircyanobacteriahost
_version_	1718421328844816384

Analysis and phylogeny of small heat shock proteins from marine viruses and their cyanobacteria host.

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