Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium

Kim et al. conducted single-cell RNA sequencing to determine the transcriptome profiles of human nail units using polydactyly specimens to demonstrate mesenchymal and epithelial cell populations, characterized by RSPO4 and SPINK6 respectively. RSPO4 + onychofibroblasts localized with LGR6 + nail mat...

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Autores principales:	Hyun Je Kim, Joon Ho Shim, Ji-Hye Park, Hyun Tae Shin, Jong Sup Shim, Kee-Taek Jang, Woong-Yang Park, Kyung-Hoon Lee, Eun Ji Kwon, Hyung-Suk Jang, Hanseul Yang, Jong Hee Lee, Jun-Mo Yang, Dongyoun Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/72794da6943345f1a6962eac5e3e7443
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spelling	oai:doaj.org-article:72794da6943345f1a6962eac5e3e74432021-12-02T17:34:48ZSingle-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium10.1038/s42003-021-02223-w2399-3642https://doaj.org/article/72794da6943345f1a6962eac5e3e74432021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02223-whttps://doaj.org/toc/2399-3642Kim et al. conducted single-cell RNA sequencing to determine the transcriptome profiles of human nail units using polydactyly specimens to demonstrate mesenchymal and epithelial cell populations, characterized by RSPO4 and SPINK6 respectively. RSPO4 + onychofibroblasts localized with LGR6 + nail matrix, leading to WNT/ β-catenin activation and suggesting a role for onychofibroblasts in onychomatricoma pathogenesis.Hyun Je KimJoon Ho ShimJi-Hye ParkHyun Tae ShinJong Sup ShimKee-Taek JangWoong-Yang ParkKyung-Hoon LeeEun Ji KwonHyung-Suk JangHanseul YangJong Hee LeeJun-Mo YangDongyoun LeeNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Hyun Je Kim Joon Ho Shim Ji-Hye Park Hyun Tae Shin Jong Sup Shim Kee-Taek Jang Woong-Yang Park Kyung-Hoon Lee Eun Ji Kwon Hyung-Suk Jang Hanseul Yang Jong Hee Lee Jun-Mo Yang Dongyoun Lee Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium
description	Kim et al. conducted single-cell RNA sequencing to determine the transcriptome profiles of human nail units using polydactyly specimens to demonstrate mesenchymal and epithelial cell populations, characterized by RSPO4 and SPINK6 respectively. RSPO4 + onychofibroblasts localized with LGR6 + nail matrix, leading to WNT/ β-catenin activation and suggesting a role for onychofibroblasts in onychomatricoma pathogenesis.
format	article
author	Hyun Je Kim Joon Ho Shim Ji-Hye Park Hyun Tae Shin Jong Sup Shim Kee-Taek Jang Woong-Yang Park Kyung-Hoon Lee Eun Ji Kwon Hyung-Suk Jang Hanseul Yang Jong Hee Lee Jun-Mo Yang Dongyoun Lee
author_facet	Hyun Je Kim Joon Ho Shim Ji-Hye Park Hyun Tae Shin Jong Sup Shim Kee-Taek Jang Woong-Yang Park Kyung-Hoon Lee Eun Ji Kwon Hyung-Suk Jang Hanseul Yang Jong Hee Lee Jun-Mo Yang Dongyoun Lee
author_sort	Hyun Je Kim
title	Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium
title_short	Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium
title_full	Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium
title_fullStr	Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium
title_full_unstemmed	Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium
title_sort	single-cell rna sequencing of human nail unit defines rspo4 onychofibroblasts and spink6 nail epithelium
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/72794da6943345f1a6962eac5e3e7443
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Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium

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