INFLUENCE OF CD14 GENE POLYMORHISM ON CLINIC AL COURSE AND OUTCOME OF NOSOCOMIAL PNEUMONIA

Genotypes CD14 gene genotypes frequencies of in control group and in group of patients with nosocomial pneumonia (NP) correspond to Hardy-Weinberg law. We revealed a statistically significant increase of genotype Т/Т frequency in the patients with NP (33.33%) in contrast to control group (18.09%) (р...

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Autores principales:	E. A. Baygozina, V. I. Sovalkin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	polymorphism gene cd14 nosocomial pneumonia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7279865b3d6b41ab8759b8389f2ac896
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spelling	oai:doaj.org-article:7279865b3d6b41ab8759b8389f2ac8962021-11-18T08:03:37ZINFLUENCE OF CD14 GENE POLYMORHISM ON CLINIC AL COURSE AND OUTCOME OF NOSOCOMIAL PNEUMONIA1563-06252313-741X10.15789/1563-0625-2010-1-2-95-102https://doaj.org/article/7279865b3d6b41ab8759b8389f2ac8962014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/50https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XGenotypes CD14 gene genotypes frequencies of in control group and in group of patients with nosocomial pneumonia (NP) correspond to Hardy-Weinberg law. We revealed a statistically significant increase of genotype Т/Т frequency in the patients with NP (33.33%) in contrast to control group (18.09%) (р = 0.008). Notable is a difference in severity of NP cours in the patients with C/С, C/Т and Т/Т genotypes. In first case, the score of discase severity, using CPIS scale, was 7.81±1.32, whereas in second case it was 8.93±1.48 (р < 0.05). A positive correlation was found between resolution time of NP and CD14 genotype, i.e. Т/Т genotype was associated with prolonged respiratory support in NP with mecanical ventilation, as compared with NP cases in the patlents with C/С and C/Т genotypes (r = 0.70; р = 0.01). It was shown that the patients with CD14 Т/Т genotype exhibited hypercytokinemia due to TNFα. IL-1β and IL-1RN, thus pointing to a key role of CD14 gene polymorphism in immune pathogenesis of NP.E. A. BaygozinaV. I. SovalkinSPb RAACIarticlepolymorphismgenecd14nosocomial pneumoniaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 1-2, Pp 95-102 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	polymorphism gene cd14 nosocomial pneumonia Immunologic diseases. Allergy RC581-607
spellingShingle	polymorphism gene cd14 nosocomial pneumonia Immunologic diseases. Allergy RC581-607 E. A. Baygozina V. I. Sovalkin INFLUENCE OF CD14 GENE POLYMORHISM ON CLINIC AL COURSE AND OUTCOME OF NOSOCOMIAL PNEUMONIA
description	Genotypes CD14 gene genotypes frequencies of in control group and in group of patients with nosocomial pneumonia (NP) correspond to Hardy-Weinberg law. We revealed a statistically significant increase of genotype Т/Т frequency in the patients with NP (33.33%) in contrast to control group (18.09%) (р = 0.008). Notable is a difference in severity of NP cours in the patients with C/С, C/Т and Т/Т genotypes. In first case, the score of discase severity, using CPIS scale, was 7.81±1.32, whereas in second case it was 8.93±1.48 (р < 0.05). A positive correlation was found between resolution time of NP and CD14 genotype, i.e. Т/Т genotype was associated with prolonged respiratory support in NP with mecanical ventilation, as compared with NP cases in the patlents with C/С and C/Т genotypes (r = 0.70; р = 0.01). It was shown that the patients with CD14 Т/Т genotype exhibited hypercytokinemia due to TNFα. IL-1β and IL-1RN, thus pointing to a key role of CD14 gene polymorphism in immune pathogenesis of NP.
format	article
author	E. A. Baygozina V. I. Sovalkin
author_facet	E. A. Baygozina V. I. Sovalkin
author_sort	E. A. Baygozina
title	INFLUENCE OF CD14 GENE POLYMORHISM ON CLINIC AL COURSE AND OUTCOME OF NOSOCOMIAL PNEUMONIA
title_short	INFLUENCE OF CD14 GENE POLYMORHISM ON CLINIC AL COURSE AND OUTCOME OF NOSOCOMIAL PNEUMONIA
title_full	INFLUENCE OF CD14 GENE POLYMORHISM ON CLINIC AL COURSE AND OUTCOME OF NOSOCOMIAL PNEUMONIA
title_fullStr	INFLUENCE OF CD14 GENE POLYMORHISM ON CLINIC AL COURSE AND OUTCOME OF NOSOCOMIAL PNEUMONIA
title_full_unstemmed	INFLUENCE OF CD14 GENE POLYMORHISM ON CLINIC AL COURSE AND OUTCOME OF NOSOCOMIAL PNEUMONIA
title_sort	influence of cd14 gene polymorhism on clinic al course and outcome of nosocomial pneumonia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/7279865b3d6b41ab8759b8389f2ac896
work_keys_str_mv	AT eabaygozina influenceofcd14genepolymorhismonclinicalcourseandoutcomeofnosocomialpneumonia AT visovalkin influenceofcd14genepolymorhismonclinicalcourseandoutcomeofnosocomialpneumonia
_version_	1718422551379574784

INFLUENCE OF CD14 GENE POLYMORHISM ON CLINIC AL COURSE AND OUTCOME OF NOSOCOMIAL PNEUMONIA

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