ASSOCIATION BETWEEN CYTOKINE GENE POLYMORPHISMS AND RECURRENT MISCARRIAGE

Associations between IL1B (rs1143634), IL1RN (VNTR, intron 2), IL4 (VNTR, intron 3), TNFA (rs1800629, rs361525), IL6 (rs1800795), and IL10 (rs1800896) genetic polymorphisms in women with recurrent miscarriage (RM) were analyzed. We studied DNA samples of 112 women with RM and 267 women with physiolo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	L A. Gordeeva, O. S. Oskorbina, E. N. Voronina, E. A. Sokolova, I. V. Shatalina, R. V. Olennikova, S. L. Nersesyan, M. L. Filipenko, A. N. Glushkov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	cytokines genetic polymorphisms recurrent miscarriage early spontaneous abortion Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/727b53af10c54379bc1a0a793517dffa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:727b53af10c54379bc1a0a793517dffa
record_format	dspace
spelling	oai:doaj.org-article:727b53af10c54379bc1a0a793517dffa2021-11-18T08:03:46ZASSOCIATION BETWEEN CYTOKINE GENE POLYMORPHISMS AND RECURRENT MISCARRIAGE1563-06252313-741X10.15789/1563-0625-2017-5-585-596https://doaj.org/article/727b53af10c54379bc1a0a793517dffa2017-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1360https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAssociations between IL1B (rs1143634), IL1RN (VNTR, intron 2), IL4 (VNTR, intron 3), TNFA (rs1800629, rs361525), IL6 (rs1800795), and IL10 (rs1800896) genetic polymorphisms in women with recurrent miscarriage (RM) were analyzed. We studied DNA samples of 112 women with RM and 267 women with physiological pregnancy. The IL1RN, IL4 genotypes were identified by PCR techniques, the IL1B, IL6 gene polymorphisms were defined by means of RFLP approach. To detect TNFA and IL10 gene polymorphisms, TaqMan real-time PCR was used. The results have shown that polymorphic loci of IL1B, IL1RN, IL10, TNFA genes were not associated with RM, and early spontaneous abortion risk. The 2R allele of IL4 gene was found to be associated with higher RM risk (OR = 1.52; 95% CI = [1.08-2.14]; P-value (cor) = 0.05), and G allele of IL6 gene was associated with a risk for > 3 early spontaneous abortions (OR = 2.10; 95% CI = [1.24-3.56]; P-value (cor) = 0.05), in an additive inheritance model. Upon evaluation of the data obtained, one may conclude that the IL4 (VNTR intron 3) and IL6 (rs1800795) gene polymorphisms could influence the RM development. These results may be useful for assessment of molecular mechanisms underlying early spontaneous abortion.L A. GordeevaO. S. OskorbinaE. N. VoroninaE. A. SokolovaI. V. ShatalinaR. V. OlennikovaS. L. NersesyanM. L. FilipenkoA. N. GlushkovSPb RAACIarticlecytokinesgenetic polymorphismsrecurrent miscarriageearly spontaneous abortionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 5, Pp 585-596 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines genetic polymorphisms recurrent miscarriage early spontaneous abortion Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines genetic polymorphisms recurrent miscarriage early spontaneous abortion Immunologic diseases. Allergy RC581-607 L A. Gordeeva O. S. Oskorbina E. N. Voronina E. A. Sokolova I. V. Shatalina R. V. Olennikova S. L. Nersesyan M. L. Filipenko A. N. Glushkov ASSOCIATION BETWEEN CYTOKINE GENE POLYMORPHISMS AND RECURRENT MISCARRIAGE
description	Associations between IL1B (rs1143634), IL1RN (VNTR, intron 2), IL4 (VNTR, intron 3), TNFA (rs1800629, rs361525), IL6 (rs1800795), and IL10 (rs1800896) genetic polymorphisms in women with recurrent miscarriage (RM) were analyzed. We studied DNA samples of 112 women with RM and 267 women with physiological pregnancy. The IL1RN, IL4 genotypes were identified by PCR techniques, the IL1B, IL6 gene polymorphisms were defined by means of RFLP approach. To detect TNFA and IL10 gene polymorphisms, TaqMan real-time PCR was used. The results have shown that polymorphic loci of IL1B, IL1RN, IL10, TNFA genes were not associated with RM, and early spontaneous abortion risk. The 2R allele of IL4 gene was found to be associated with higher RM risk (OR = 1.52; 95% CI = [1.08-2.14]; P-value (cor) = 0.05), and G allele of IL6 gene was associated with a risk for > 3 early spontaneous abortions (OR = 2.10; 95% CI = [1.24-3.56]; P-value (cor) = 0.05), in an additive inheritance model. Upon evaluation of the data obtained, one may conclude that the IL4 (VNTR intron 3) and IL6 (rs1800795) gene polymorphisms could influence the RM development. These results may be useful for assessment of molecular mechanisms underlying early spontaneous abortion.
format	article
author	L A. Gordeeva O. S. Oskorbina E. N. Voronina E. A. Sokolova I. V. Shatalina R. V. Olennikova S. L. Nersesyan M. L. Filipenko A. N. Glushkov
author_facet	L A. Gordeeva O. S. Oskorbina E. N. Voronina E. A. Sokolova I. V. Shatalina R. V. Olennikova S. L. Nersesyan M. L. Filipenko A. N. Glushkov
author_sort	L A. Gordeeva
title	ASSOCIATION BETWEEN CYTOKINE GENE POLYMORPHISMS AND RECURRENT MISCARRIAGE
title_short	ASSOCIATION BETWEEN CYTOKINE GENE POLYMORPHISMS AND RECURRENT MISCARRIAGE
title_full	ASSOCIATION BETWEEN CYTOKINE GENE POLYMORPHISMS AND RECURRENT MISCARRIAGE
title_fullStr	ASSOCIATION BETWEEN CYTOKINE GENE POLYMORPHISMS AND RECURRENT MISCARRIAGE
title_full_unstemmed	ASSOCIATION BETWEEN CYTOKINE GENE POLYMORPHISMS AND RECURRENT MISCARRIAGE
title_sort	association between cytokine gene polymorphisms and recurrent miscarriage
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/727b53af10c54379bc1a0a793517dffa
work_keys_str_mv	AT lagordeeva associationbetweencytokinegenepolymorphismsandrecurrentmiscarriage AT ososkorbina associationbetweencytokinegenepolymorphismsandrecurrentmiscarriage AT envoronina associationbetweencytokinegenepolymorphismsandrecurrentmiscarriage AT easokolova associationbetweencytokinegenepolymorphismsandrecurrentmiscarriage AT ivshatalina associationbetweencytokinegenepolymorphismsandrecurrentmiscarriage AT rvolennikova associationbetweencytokinegenepolymorphismsandrecurrentmiscarriage AT slnersesyan associationbetweencytokinegenepolymorphismsandrecurrentmiscarriage AT mlfilipenko associationbetweencytokinegenepolymorphismsandrecurrentmiscarriage AT anglushkov associationbetweencytokinegenepolymorphismsandrecurrentmiscarriage
_version_	1718422360269258752

ASSOCIATION BETWEEN CYTOKINE GENE POLYMORPHISMS AND RECURRENT MISCARRIAGE

Ejemplares similares