Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders

Abstract Nocturnal enuresis (NE) is a common problem among 10% school-aged children. The etiologies underlying childhood NE is complex and not fully understood nowadays. Nevertheless, increasing evidence suggests a potential link between neurobehavioral disorders and enuresis in children. In this st...

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Autores principales:	Mei-Ching Yu, Ta-Min Wang, Yee-Hsuan Chiou, Meng-Kung Yu, Chiao-Fan Lin, Chih-Yung Chiu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/727b5826c3324bb3854eb0d231174e37
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spelling	oai:doaj.org-article:727b5826c3324bb3854eb0d231174e372021-12-02T17:08:35ZUrine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders10.1038/s41598-021-96104-12045-2322https://doaj.org/article/727b5826c3324bb3854eb0d231174e372021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96104-1https://doaj.org/toc/2045-2322Abstract Nocturnal enuresis (NE) is a common problem among 10% school-aged children. The etiologies underlying childhood NE is complex and not fully understood nowadays. Nevertheless, increasing evidence suggests a potential link between neurobehavioral disorders and enuresis in children. In this study, we aimed to explore novel metabolomic insights into the pathophysiology of NE and also, its association with pediatric psychiatric problems. Urine collected from 41 bedwetting children and 27 healthy control children was analyzed by using 1H-nuclear magnetic resonance spectroscopy from August 2017 to December 2018. At regular follow-up, there were 14 children with refractory NE having a diagnosis of attention deficient hyperactivity disorder (ADHD) or anxiety. Eventually, we identified eight significantly differential urinary metabolites and particularly increased urinary excretion of betaine, creatine and guanidinoacetate linked to glycine, serine and threonine metabolism were associated with a comorbidity of neurobehavioral disorders in refractory bedwetting children. Notably, based on physiological functions of betaine acting as a renal osmolyte and methyl group donor, we speculated its potential role in modulation of renal and/or central circadian clock systems, becoming a useful urinary metabolic marker in diagnosis of treatment-resistant NE in children affected by these two disorders.Mei-Ching YuTa-Min WangYee-Hsuan ChiouMeng-Kung YuChiao-Fan LinChih-Yung ChiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mei-Ching Yu Ta-Min Wang Yee-Hsuan Chiou Meng-Kung Yu Chiao-Fan Lin Chih-Yung Chiu Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders
description	Abstract Nocturnal enuresis (NE) is a common problem among 10% school-aged children. The etiologies underlying childhood NE is complex and not fully understood nowadays. Nevertheless, increasing evidence suggests a potential link between neurobehavioral disorders and enuresis in children. In this study, we aimed to explore novel metabolomic insights into the pathophysiology of NE and also, its association with pediatric psychiatric problems. Urine collected from 41 bedwetting children and 27 healthy control children was analyzed by using 1H-nuclear magnetic resonance spectroscopy from August 2017 to December 2018. At regular follow-up, there were 14 children with refractory NE having a diagnosis of attention deficient hyperactivity disorder (ADHD) or anxiety. Eventually, we identified eight significantly differential urinary metabolites and particularly increased urinary excretion of betaine, creatine and guanidinoacetate linked to glycine, serine and threonine metabolism were associated with a comorbidity of neurobehavioral disorders in refractory bedwetting children. Notably, based on physiological functions of betaine acting as a renal osmolyte and methyl group donor, we speculated its potential role in modulation of renal and/or central circadian clock systems, becoming a useful urinary metabolic marker in diagnosis of treatment-resistant NE in children affected by these two disorders.
format	article
author	Mei-Ching Yu Ta-Min Wang Yee-Hsuan Chiou Meng-Kung Yu Chiao-Fan Lin Chih-Yung Chiu
author_facet	Mei-Ching Yu Ta-Min Wang Yee-Hsuan Chiou Meng-Kung Yu Chiao-Fan Lin Chih-Yung Chiu
author_sort	Mei-Ching Yu
title	Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders
title_short	Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders
title_full	Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders
title_fullStr	Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders
title_full_unstemmed	Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders
title_sort	urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/727b5826c3324bb3854eb0d231174e37
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Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders

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