Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

Fatemeh Ebrahimi,1,2 Amirhossein Sahebkar,3–5 Naheed Aryaeian,2 Naseh Pahlavani,6 Soudabeh Fallah,7 Nariman Moradi,8 Davoud Abbasi,9 Agha Fatemeh Hosseini10 1Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Nut...

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Autores principales:	Ebrahimi F, Sahebkar A, Aryaeian N, Pahlavani N, Fallah S, Moradi N, Abbasi D, Hosseini AF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Crocus Sativus Diabetes Mellitus Type 2 Dysglycemia Lipid profile Inflammation Mediators Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/727ce645e0b143739a539642896d855e
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spelling	oai:doaj.org-article:727ce645e0b143739a539642896d855e2021-12-02T05:41:07ZEffects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial1178-7007https://doaj.org/article/727ce645e0b143739a539642896d855e2019-10-01T00:00:00Zhttps://www.dovepress.com/effects-of-saffron-supplementation-on-inflammation-and-metabolic-respo-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Fatemeh Ebrahimi,1,2 Amirhossein Sahebkar,3–5 Naheed Aryaeian,2 Naseh Pahlavani,6 Soudabeh Fallah,7 Nariman Moradi,8 Davoud Abbasi,9 Agha Fatemeh Hosseini10 1Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; 3Halal Research Center of IRI, FDA, Tehran, Iran; 4Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; 5Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 6Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran; 7Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; 8Department of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran; 9Department of Internal Medicine, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; 10Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, IranCorrespondence: Naheed AryaeianDepartment of Nutrition, School of Public Health, Iran University of Medical Sciences, Shahid Hemmat Expressway, Iran University of Medical Sciences, Hemat Highway next to Milad Towe Tehran, Tehran 1449614535, IranTel +98-912-3093353Fax +98-21-8862253Email Aryaeian.n@iums.ac.irBackground: Type 2 diabetes (T2D) is accompanied by elevated inflammation, oxidative stress, hyperlipidemia and hyperglycemia which all contribute to cardiovascular disease pathogenesis. Saffron as a complementary medicine and source of antioxidants could play a role in alleviating diabetes and its complications. The aim of this study was to determine the effects of saffron supplementation as an adjunct therapy in T2D.Patients and methods: This randomized controlled trial included 80 T2D patients with a mean age of 54.1 years. Participants were randomly assigned into two groups to take either saffron tablets (100 mg/day; n=40) or placebo (n=40) for 12 weeks. Fasting blood samples were obtained at the beginning and after the intervention period to quantify glycemic factors, lipid profile, and biomarkers of inflammation and oxidative stress. Anthropometric indices and dietary intakes were also measured at baseline and at study end.Results: Compared with placebo, saffron supplementation resulted in significant decreases in waist circumference (p<0.001) and malondialdehyde (MDA) (p=0.001). There was no statistically significant difference in other indices, including anthropometric parameters, serum insulin, fasting blood glucose, HbA1c, insulin sensitivity indices, lipid profile, high-sensitivity C-reactive protein, total antioxidant capacity, and tumor necrosis factor-α between the study groups (p>0.05).Conclusion: Overall, 12 weeks of saffron supplementation in diabetic patients had beneficial effects on waist circumference and serum MDA levels. However, saffron did not influence other evaluated cardio metabolic risk markers in diabetic patients.Keywords: crocus sativus, diabetes mellitus, type 2, dysglycemia, lipid profile, inflammation mediatorsEbrahimi FSahebkar AAryaeian NPahlavani NFallah SMoradi NAbbasi DHosseini AFDove Medical PressarticleCrocus SativusDiabetes MellitusType 2DysglycemiaLipid profileInflammation MediatorsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 2107-2115 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Crocus Sativus Diabetes Mellitus Type 2 Dysglycemia Lipid profile Inflammation Mediators Specialties of internal medicine RC581-951
spellingShingle	Crocus Sativus Diabetes Mellitus Type 2 Dysglycemia Lipid profile Inflammation Mediators Specialties of internal medicine RC581-951 Ebrahimi F Sahebkar A Aryaeian N Pahlavani N Fallah S Moradi N Abbasi D Hosseini AF Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
description	Fatemeh Ebrahimi,1,2 Amirhossein Sahebkar,3–5 Naheed Aryaeian,2 Naseh Pahlavani,6 Soudabeh Fallah,7 Nariman Moradi,8 Davoud Abbasi,9 Agha Fatemeh Hosseini10 1Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; 3Halal Research Center of IRI, FDA, Tehran, Iran; 4Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; 5Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 6Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran; 7Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; 8Department of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran; 9Department of Internal Medicine, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; 10Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, IranCorrespondence: Naheed AryaeianDepartment of Nutrition, School of Public Health, Iran University of Medical Sciences, Shahid Hemmat Expressway, Iran University of Medical Sciences, Hemat Highway next to Milad Towe Tehran, Tehran 1449614535, IranTel +98-912-3093353Fax +98-21-8862253Email Aryaeian.n@iums.ac.irBackground: Type 2 diabetes (T2D) is accompanied by elevated inflammation, oxidative stress, hyperlipidemia and hyperglycemia which all contribute to cardiovascular disease pathogenesis. Saffron as a complementary medicine and source of antioxidants could play a role in alleviating diabetes and its complications. The aim of this study was to determine the effects of saffron supplementation as an adjunct therapy in T2D.Patients and methods: This randomized controlled trial included 80 T2D patients with a mean age of 54.1 years. Participants were randomly assigned into two groups to take either saffron tablets (100 mg/day; n=40) or placebo (n=40) for 12 weeks. Fasting blood samples were obtained at the beginning and after the intervention period to quantify glycemic factors, lipid profile, and biomarkers of inflammation and oxidative stress. Anthropometric indices and dietary intakes were also measured at baseline and at study end.Results: Compared with placebo, saffron supplementation resulted in significant decreases in waist circumference (p<0.001) and malondialdehyde (MDA) (p=0.001). There was no statistically significant difference in other indices, including anthropometric parameters, serum insulin, fasting blood glucose, HbA1c, insulin sensitivity indices, lipid profile, high-sensitivity C-reactive protein, total antioxidant capacity, and tumor necrosis factor-α between the study groups (p>0.05).Conclusion: Overall, 12 weeks of saffron supplementation in diabetic patients had beneficial effects on waist circumference and serum MDA levels. However, saffron did not influence other evaluated cardio metabolic risk markers in diabetic patients.Keywords: crocus sativus, diabetes mellitus, type 2, dysglycemia, lipid profile, inflammation mediators
format	article
author	Ebrahimi F Sahebkar A Aryaeian N Pahlavani N Fallah S Moradi N Abbasi D Hosseini AF
author_facet	Ebrahimi F Sahebkar A Aryaeian N Pahlavani N Fallah S Moradi N Abbasi D Hosseini AF
author_sort	Ebrahimi F
title	Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
title_short	Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
title_full	Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
title_fullStr	Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
title_full_unstemmed	Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
title_sort	effects of saffron supplementation on inflammation and metabolic responses in type 2 diabetic patients: a randomized, double-blind, placebo-controlled trial
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/727ce645e0b143739a539642896d855e
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Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

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