Interrelation Between Fibroblasts and T Cells in Fibrosing Interstitial Lung Diseases

Interstitial lung diseases (ILDs) are a heterogeneous group of diseases characterized by varying degrees of inflammation and fibrosis of the pulmonary interstitium. The interrelations between multiple immune cells and stromal cells participate in the pathogenesis of ILDs. While fibroblasts contribut...

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Autores principales:	Yunxin Lai, Xinru Wei, Ting Ye, Lilin Hang, Ling Mou, Jin Su
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	fibroblasts T cells interrelation ILDs fibrosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/727f01b1ff0c40298c03bb2ee852bd2f
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spelling	oai:doaj.org-article:727f01b1ff0c40298c03bb2ee852bd2f2021-11-05T06:46:01ZInterrelation Between Fibroblasts and T Cells in Fibrosing Interstitial Lung Diseases1664-322410.3389/fimmu.2021.747335https://doaj.org/article/727f01b1ff0c40298c03bb2ee852bd2f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.747335/fullhttps://doaj.org/toc/1664-3224Interstitial lung diseases (ILDs) are a heterogeneous group of diseases characterized by varying degrees of inflammation and fibrosis of the pulmonary interstitium. The interrelations between multiple immune cells and stromal cells participate in the pathogenesis of ILDs. While fibroblasts contribute to the development of ILDs through secreting extracellular matrix and proinflammatory cytokines upon activation, T cells are major mediators of adaptive immunity, as well as inflammation and autoimmune tissue destruction in the lung of ILDs patients. Fibroblasts play important roles in modulating T cell recruitment, differentiation and function and conversely, T cells can balance fibrotic sequelae with protective immunity in the lung. A more precise understanding of the interrelation between fibroblasts and T cells will enable a better future therapeutic design by targeting this interrelationship. Here we highlight recent work on the interactions between fibroblasts and T cells in ILDs, and consider the implications of these interactions in the future development of therapies for ILDs.Yunxin LaiXinru WeiTing YeLilin HangLing MouJin SuFrontiers Media S.A.articlefibroblastsT cellsinterrelationILDsfibrosisImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fibroblasts T cells interrelation ILDs fibrosis Immunologic diseases. Allergy RC581-607
spellingShingle	fibroblasts T cells interrelation ILDs fibrosis Immunologic diseases. Allergy RC581-607 Yunxin Lai Xinru Wei Ting Ye Lilin Hang Ling Mou Jin Su Interrelation Between Fibroblasts and T Cells in Fibrosing Interstitial Lung Diseases
description	Interstitial lung diseases (ILDs) are a heterogeneous group of diseases characterized by varying degrees of inflammation and fibrosis of the pulmonary interstitium. The interrelations between multiple immune cells and stromal cells participate in the pathogenesis of ILDs. While fibroblasts contribute to the development of ILDs through secreting extracellular matrix and proinflammatory cytokines upon activation, T cells are major mediators of adaptive immunity, as well as inflammation and autoimmune tissue destruction in the lung of ILDs patients. Fibroblasts play important roles in modulating T cell recruitment, differentiation and function and conversely, T cells can balance fibrotic sequelae with protective immunity in the lung. A more precise understanding of the interrelation between fibroblasts and T cells will enable a better future therapeutic design by targeting this interrelationship. Here we highlight recent work on the interactions between fibroblasts and T cells in ILDs, and consider the implications of these interactions in the future development of therapies for ILDs.
format	article
author	Yunxin Lai Xinru Wei Ting Ye Lilin Hang Ling Mou Jin Su
author_facet	Yunxin Lai Xinru Wei Ting Ye Lilin Hang Ling Mou Jin Su
author_sort	Yunxin Lai
title	Interrelation Between Fibroblasts and T Cells in Fibrosing Interstitial Lung Diseases
title_short	Interrelation Between Fibroblasts and T Cells in Fibrosing Interstitial Lung Diseases
title_full	Interrelation Between Fibroblasts and T Cells in Fibrosing Interstitial Lung Diseases
title_fullStr	Interrelation Between Fibroblasts and T Cells in Fibrosing Interstitial Lung Diseases
title_full_unstemmed	Interrelation Between Fibroblasts and T Cells in Fibrosing Interstitial Lung Diseases
title_sort	interrelation between fibroblasts and t cells in fibrosing interstitial lung diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/727f01b1ff0c40298c03bb2ee852bd2f
work_keys_str_mv	AT yunxinlai interrelationbetweenfibroblastsandtcellsinfibrosinginterstitiallungdiseases AT xinruwei interrelationbetweenfibroblastsandtcellsinfibrosinginterstitiallungdiseases AT tingye interrelationbetweenfibroblastsandtcellsinfibrosinginterstitiallungdiseases AT lilinhang interrelationbetweenfibroblastsandtcellsinfibrosinginterstitiallungdiseases AT lingmou interrelationbetweenfibroblastsandtcellsinfibrosinginterstitiallungdiseases AT jinsu interrelationbetweenfibroblastsandtcellsinfibrosinginterstitiallungdiseases
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Interrelation Between Fibroblasts and T Cells in Fibrosing Interstitial Lung Diseases

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