Hemodynamic and Morphological Analysis of Mirror Aneurysms Prior to Rupture

Jinlong Yuan,1,* Chenlei Huang,2,* Niansheng Lai,1 Zhenbao Li,1 Xiaochun Jiang,1 Xuanzhi Wang,1 Xintong Zhao,1 Degang Wu,1 Jiaqiang Liu,1 Dayong Xia,1 Xinggen Fang1 1Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu, People’s Repu...

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Autores principales:	Yuan J, Huang C, Lai N, Li Z, Jiang X, Wang X, Zhao X, Wu D, Liu J, Xia D, Fang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	mirror aneurysms computational fluid dynamics hemodynamics morphological rupture Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/727fc7f75a9e474fb9b1c79b80e8803e
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spelling	oai:doaj.org-article:727fc7f75a9e474fb9b1c79b80e8803e2021-12-02T10:07:55ZHemodynamic and Morphological Analysis of Mirror Aneurysms Prior to Rupture1178-2021https://doaj.org/article/727fc7f75a9e474fb9b1c79b80e8803e2020-05-01T00:00:00Zhttps://www.dovepress.com/hemodynamic-and-morphological-analysis-of-mirror-aneurysms-prior-to-ru-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jinlong Yuan,1,* Chenlei Huang,2,* Niansheng Lai,1 Zhenbao Li,1 Xiaochun Jiang,1 Xuanzhi Wang,1 Xintong Zhao,1 Degang Wu,1 Jiaqiang Liu,1 Dayong Xia,1 Xinggen Fang1 1Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu, People’s Republic of China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinggen Fang Email 18805536056@163.com; xiady1981@163.comObjective: Hemodynamic factors are thought to play important roles in the pathogenesis, progression, and rupture of cerebral aneurysms. Previous hemodynamic studies have been based on comparisons between post-ruptured and unruptured aneurysms. Nevertheless, changes of aneurysm morphology after rupture render these results unreliable. Moreover, pressure, age, gender, and the morphology of the parent artery also influence these results. Therefore, in the present study, we identified hemodynamic and morphological characteristics of aneurysms prior to rupture using twelve mirror aneurysms.Materials and Methods: From our database, we retrospectively analyzed twelve mirror aneurysms (MANs) prior to rupture. Each mirror aneurysm was divided into the prior to rupture or the unruptured group. Patient-specific models were reconstructed from three-dimensional (3D) images of all patients. Hemodynamic and morphological factors were analyzed and compared.Results: Compared with the unruptured side of MANs, aneurysms prior to rupture were significantly larger and significantly more irregular in shape; they also had significantly higher aspect ratio (AR), size ratio (SR), undulation index (UI), ellipticity index (EI), percentage of low wall shear stress area (LSA) and significantly lower normal wall shear stress (NWSS). The oscillatory shear index (OSI) and nonsphericity index (NSI) in the aneurysms prior to rupture were non-significantly higher than those of the unruptured group.Conclusion: MANs prior to rupture may be extremely useful models to assess the risk of aneurysm rupture. Larger size, irregular shape, higher AR, SR, UI, NI, and lower WSS may be associated with aneurysms at risk for rupture.Keywords: mirror aneurysms, computational fluid dynamics, hemodynamics, morphological, ruptureYuan JHuang CLai NLi ZJiang XWang XZhao XWu DLiu JXia DFang XDove Medical Pressarticlemirror aneurysmscomputational fluid dynamicshemodynamicsmorphologicalruptureNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1339-1347 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	mirror aneurysms computational fluid dynamics hemodynamics morphological rupture Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	mirror aneurysms computational fluid dynamics hemodynamics morphological rupture Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yuan J Huang C Lai N Li Z Jiang X Wang X Zhao X Wu D Liu J Xia D Fang X Hemodynamic and Morphological Analysis of Mirror Aneurysms Prior to Rupture
description	Jinlong Yuan,1,* Chenlei Huang,2,* Niansheng Lai,1 Zhenbao Li,1 Xiaochun Jiang,1 Xuanzhi Wang,1 Xintong Zhao,1 Degang Wu,1 Jiaqiang Liu,1 Dayong Xia,1 Xinggen Fang1 1Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu, People’s Republic of China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinggen Fang Email 18805536056@163.com; xiady1981@163.comObjective: Hemodynamic factors are thought to play important roles in the pathogenesis, progression, and rupture of cerebral aneurysms. Previous hemodynamic studies have been based on comparisons between post-ruptured and unruptured aneurysms. Nevertheless, changes of aneurysm morphology after rupture render these results unreliable. Moreover, pressure, age, gender, and the morphology of the parent artery also influence these results. Therefore, in the present study, we identified hemodynamic and morphological characteristics of aneurysms prior to rupture using twelve mirror aneurysms.Materials and Methods: From our database, we retrospectively analyzed twelve mirror aneurysms (MANs) prior to rupture. Each mirror aneurysm was divided into the prior to rupture or the unruptured group. Patient-specific models were reconstructed from three-dimensional (3D) images of all patients. Hemodynamic and morphological factors were analyzed and compared.Results: Compared with the unruptured side of MANs, aneurysms prior to rupture were significantly larger and significantly more irregular in shape; they also had significantly higher aspect ratio (AR), size ratio (SR), undulation index (UI), ellipticity index (EI), percentage of low wall shear stress area (LSA) and significantly lower normal wall shear stress (NWSS). The oscillatory shear index (OSI) and nonsphericity index (NSI) in the aneurysms prior to rupture were non-significantly higher than those of the unruptured group.Conclusion: MANs prior to rupture may be extremely useful models to assess the risk of aneurysm rupture. Larger size, irregular shape, higher AR, SR, UI, NI, and lower WSS may be associated with aneurysms at risk for rupture.Keywords: mirror aneurysms, computational fluid dynamics, hemodynamics, morphological, rupture
format	article
author	Yuan J Huang C Lai N Li Z Jiang X Wang X Zhao X Wu D Liu J Xia D Fang X
author_facet	Yuan J Huang C Lai N Li Z Jiang X Wang X Zhao X Wu D Liu J Xia D Fang X
author_sort	Yuan J
title	Hemodynamic and Morphological Analysis of Mirror Aneurysms Prior to Rupture
title_short	Hemodynamic and Morphological Analysis of Mirror Aneurysms Prior to Rupture
title_full	Hemodynamic and Morphological Analysis of Mirror Aneurysms Prior to Rupture
title_fullStr	Hemodynamic and Morphological Analysis of Mirror Aneurysms Prior to Rupture
title_full_unstemmed	Hemodynamic and Morphological Analysis of Mirror Aneurysms Prior to Rupture
title_sort	hemodynamic and morphological analysis of mirror aneurysms prior to rupture
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/727fc7f75a9e474fb9b1c79b80e8803e
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Hemodynamic and Morphological Analysis of Mirror Aneurysms Prior to Rupture

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