Horizontal transfer of code fragments between protocells can explain the origins of the genetic code without vertical descent

Abstract Theories of the origin of the genetic code typically appeal to natural selection and/or mutation of hereditable traits to explain its regularities and error robustness, yet the present translation system presupposes high-fidelity replication. Woese’s solution to this bootstrapping problem w...

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Autores principales:	Tom Froese, Jorge I. Campos, Kosuke Fujishima, Daisuke Kiga, Nathaniel Virgo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7282068fede84953aad9112b488260ba
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spelling	oai:doaj.org-article:7282068fede84953aad9112b488260ba2021-12-02T12:31:57ZHorizontal transfer of code fragments between protocells can explain the origins of the genetic code without vertical descent10.1038/s41598-018-21973-y2045-2322https://doaj.org/article/7282068fede84953aad9112b488260ba2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21973-yhttps://doaj.org/toc/2045-2322Abstract Theories of the origin of the genetic code typically appeal to natural selection and/or mutation of hereditable traits to explain its regularities and error robustness, yet the present translation system presupposes high-fidelity replication. Woese’s solution to this bootstrapping problem was to assume that code optimization had played a key role in reducing the effect of errors caused by the early translation system. He further conjectured that initially evolution was dominated by horizontal exchange of cellular components among loosely organized protocells (“progenotes”), rather than by vertical transmission of genes. Here we simulated such communal evolution based on horizontal transfer of code fragments, possibly involving pairs of tRNAs and their cognate aminoacyl tRNA synthetases or a precursor tRNA ribozyme capable of catalysing its own aminoacylation, by using an iterated learning model. This is the first model to confirm Woese’s conjecture that regularity, optimality, and (near) universality could have emerged via horizontal interactions alone.Tom FroeseJorge I. CamposKosuke FujishimaDaisuke KigaNathaniel VirgoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tom Froese Jorge I. Campos Kosuke Fujishima Daisuke Kiga Nathaniel Virgo Horizontal transfer of code fragments between protocells can explain the origins of the genetic code without vertical descent
description	Abstract Theories of the origin of the genetic code typically appeal to natural selection and/or mutation of hereditable traits to explain its regularities and error robustness, yet the present translation system presupposes high-fidelity replication. Woese’s solution to this bootstrapping problem was to assume that code optimization had played a key role in reducing the effect of errors caused by the early translation system. He further conjectured that initially evolution was dominated by horizontal exchange of cellular components among loosely organized protocells (“progenotes”), rather than by vertical transmission of genes. Here we simulated such communal evolution based on horizontal transfer of code fragments, possibly involving pairs of tRNAs and their cognate aminoacyl tRNA synthetases or a precursor tRNA ribozyme capable of catalysing its own aminoacylation, by using an iterated learning model. This is the first model to confirm Woese’s conjecture that regularity, optimality, and (near) universality could have emerged via horizontal interactions alone.
format	article
author	Tom Froese Jorge I. Campos Kosuke Fujishima Daisuke Kiga Nathaniel Virgo
author_facet	Tom Froese Jorge I. Campos Kosuke Fujishima Daisuke Kiga Nathaniel Virgo
author_sort	Tom Froese
title	Horizontal transfer of code fragments between protocells can explain the origins of the genetic code without vertical descent
title_short	Horizontal transfer of code fragments between protocells can explain the origins of the genetic code without vertical descent
title_full	Horizontal transfer of code fragments between protocells can explain the origins of the genetic code without vertical descent
title_fullStr	Horizontal transfer of code fragments between protocells can explain the origins of the genetic code without vertical descent
title_full_unstemmed	Horizontal transfer of code fragments between protocells can explain the origins of the genetic code without vertical descent
title_sort	horizontal transfer of code fragments between protocells can explain the origins of the genetic code without vertical descent
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7282068fede84953aad9112b488260ba
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Horizontal transfer of code fragments between protocells can explain the origins of the genetic code without vertical descent

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