Catalytic defense against fungal pathogens using nanozymes

Fungal infections are still a major challenge for clinics, resulting from the resistance of drug-resistant fungi and the toxicity of antifungal drugs. Defense against fungal invasions via enzymatic catalysis has been found in nature. The use of nanozymes, as artificial enzyme mimics, may be a promis...

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Autores principales:	Qingzhi Wu, Zou Sijia, Wang Qian, Chen Lei, Yan Xiyun, Gao Lizeng
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	nanozymes antifungal reactive oxygen species enzymatic therapy catalytic defense Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
Acceso en línea:	https://doaj.org/article/72865cf6f2bf4dbb8d4c16b7ee47145e
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spelling	oai:doaj.org-article:72865cf6f2bf4dbb8d4c16b7ee47145e2021-12-05T14:10:58ZCatalytic defense against fungal pathogens using nanozymes2191-909710.1515/ntrev-2021-0084https://doaj.org/article/72865cf6f2bf4dbb8d4c16b7ee47145e2021-09-01T00:00:00Zhttps://doi.org/10.1515/ntrev-2021-0084https://doaj.org/toc/2191-9097Fungal infections are still a major challenge for clinics, resulting from the resistance of drug-resistant fungi and the toxicity of antifungal drugs. Defense against fungal invasions via enzymatic catalysis has been found in nature. The use of nanozymes, as artificial enzyme mimics, may be a promising strategy to induce fungal death due to their advantages such as tunable catalytic activity, high stability, low cost, and easy preparation. Here, the importance of natural enzymes in the defense against fungi is outlined. The progress in antifungal performance and potential application of nanozymes and the related antifungal mechanisms are also summarized. Finally, the perspective and challenges in this field for future study, pointing out that nanozyme-based catalytic therapy represents a promising alternative strategy for antifungal treatment, are highlighted.Qingzhi WuZou SijiaWang QianChen LeiYan XiyunGao LizengDe Gruyterarticlenanozymesantifungalreactive oxygen speciesenzymatic therapycatalytic defenseTechnologyTChemical technologyTP1-1185Physical and theoretical chemistryQD450-801ENNanotechnology Reviews, Vol 10, Iss 1, Pp 1277-1292 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanozymes antifungal reactive oxygen species enzymatic therapy catalytic defense Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
spellingShingle	nanozymes antifungal reactive oxygen species enzymatic therapy catalytic defense Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801 Qingzhi Wu Zou Sijia Wang Qian Chen Lei Yan Xiyun Gao Lizeng Catalytic defense against fungal pathogens using nanozymes
description	Fungal infections are still a major challenge for clinics, resulting from the resistance of drug-resistant fungi and the toxicity of antifungal drugs. Defense against fungal invasions via enzymatic catalysis has been found in nature. The use of nanozymes, as artificial enzyme mimics, may be a promising strategy to induce fungal death due to their advantages such as tunable catalytic activity, high stability, low cost, and easy preparation. Here, the importance of natural enzymes in the defense against fungi is outlined. The progress in antifungal performance and potential application of nanozymes and the related antifungal mechanisms are also summarized. Finally, the perspective and challenges in this field for future study, pointing out that nanozyme-based catalytic therapy represents a promising alternative strategy for antifungal treatment, are highlighted.
format	article
author	Qingzhi Wu Zou Sijia Wang Qian Chen Lei Yan Xiyun Gao Lizeng
author_facet	Qingzhi Wu Zou Sijia Wang Qian Chen Lei Yan Xiyun Gao Lizeng
author_sort	Qingzhi Wu
title	Catalytic defense against fungal pathogens using nanozymes
title_short	Catalytic defense against fungal pathogens using nanozymes
title_full	Catalytic defense against fungal pathogens using nanozymes
title_fullStr	Catalytic defense against fungal pathogens using nanozymes
title_full_unstemmed	Catalytic defense against fungal pathogens using nanozymes
title_sort	catalytic defense against fungal pathogens using nanozymes
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/72865cf6f2bf4dbb8d4c16b7ee47145e
work_keys_str_mv	AT qingzhiwu catalyticdefenseagainstfungalpathogensusingnanozymes AT zousijia catalyticdefenseagainstfungalpathogensusingnanozymes AT wangqian catalyticdefenseagainstfungalpathogensusingnanozymes AT chenlei catalyticdefenseagainstfungalpathogensusingnanozymes AT yanxiyun catalyticdefenseagainstfungalpathogensusingnanozymes AT gaolizeng catalyticdefenseagainstfungalpathogensusingnanozymes
_version_	1718371545415417856

Catalytic defense against fungal pathogens using nanozymes

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