Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides

In cells, DNA is arranged into topologically-constrained (supercoiled) structures, but how this supercoiling affects the detailed double-helical structure of DNA remains unclear. Here authors use atomic force microscopy and atomistic molecular dynamics simulations, to resolve structures of negativel...

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Autores principales:	Alice L. B. Pyne, Agnes Noy, Kavit H. S. Main, Victor Velasco-Berrelleza, Michael M. Piperakis, Lesley A. Mitchenall, Fiorella M. Cugliandolo, Joseph G. Beton, Clare E. M. Stevenson, Bart W. Hoogenboom, Andrew D. Bates, Anthony Maxwell, Sarah A. Harris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/728c1ae4dbb4491c9742de5d69efdcab
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spelling	oai:doaj.org-article:728c1ae4dbb4491c9742de5d69efdcab2021-12-02T12:11:16ZBase-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides10.1038/s41467-021-21243-y2041-1723https://doaj.org/article/728c1ae4dbb4491c9742de5d69efdcab2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21243-yhttps://doaj.org/toc/2041-1723In cells, DNA is arranged into topologically-constrained (supercoiled) structures, but how this supercoiling affects the detailed double-helical structure of DNA remains unclear. Here authors use atomic force microscopy and atomistic molecular dynamics simulations, to resolve structures of negatively-supercoiled DNA minicircles at base-pair resolution.Alice L. B. PyneAgnes NoyKavit H. S. MainVictor Velasco-BerrellezaMichael M. PiperakisLesley A. MitchenallFiorella M. CugliandoloJoseph G. BetonClare E. M. StevensonBart W. HoogenboomAndrew D. BatesAnthony MaxwellSarah A. HarrisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alice L. B. Pyne Agnes Noy Kavit H. S. Main Victor Velasco-Berrelleza Michael M. Piperakis Lesley A. Mitchenall Fiorella M. Cugliandolo Joseph G. Beton Clare E. M. Stevenson Bart W. Hoogenboom Andrew D. Bates Anthony Maxwell Sarah A. Harris Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides
description	In cells, DNA is arranged into topologically-constrained (supercoiled) structures, but how this supercoiling affects the detailed double-helical structure of DNA remains unclear. Here authors use atomic force microscopy and atomistic molecular dynamics simulations, to resolve structures of negatively-supercoiled DNA minicircles at base-pair resolution.
format	article
author	Alice L. B. Pyne Agnes Noy Kavit H. S. Main Victor Velasco-Berrelleza Michael M. Piperakis Lesley A. Mitchenall Fiorella M. Cugliandolo Joseph G. Beton Clare E. M. Stevenson Bart W. Hoogenboom Andrew D. Bates Anthony Maxwell Sarah A. Harris
author_facet	Alice L. B. Pyne Agnes Noy Kavit H. S. Main Victor Velasco-Berrelleza Michael M. Piperakis Lesley A. Mitchenall Fiorella M. Cugliandolo Joseph G. Beton Clare E. M. Stevenson Bart W. Hoogenboom Andrew D. Bates Anthony Maxwell Sarah A. Harris
author_sort	Alice L. B. Pyne
title	Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides
title_short	Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides
title_full	Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides
title_fullStr	Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides
title_full_unstemmed	Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides
title_sort	base-pair resolution analysis of the effect of supercoiling on dna flexibility and major groove recognition by triplex-forming oligonucleotides
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/728c1ae4dbb4491c9742de5d69efdcab
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Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides

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