NUTRITCIOGENETICS AND RISK FACTORS OF CARDIOVASCULAR DISEASE: ASSOCIATED RESEARCH IN EASTERN SIBERIA POPULATIONS

Purpose: to study nutritional habits as a risk factor of cardiovascular pathology as so as a role of apolipoprotein A1 gene in metabolism in native and alien population of Eastern Siberia. Methods: we used Kiselev questionnaire (1998) for estimation of "nutritional risk". Totally 863 adole...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	T. A. Bairova, V. V. Dolgikh, L. I. Kolesnikova, O. A. Pervushina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	nutrition ethnos genetics risk factors arterial hypertension apolipoprotein buryat russian Science Q
Acceso en línea:	https://doaj.org/article/7296373f88384a1b8fb251f39a4acdbc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7296373f88384a1b8fb251f39a4acdbc
record_format	dspace
spelling	oai:doaj.org-article:7296373f88384a1b8fb251f39a4acdbc2021-11-23T06:14:28ZNUTRITCIOGENETICS AND RISK FACTORS OF CARDIOVASCULAR DISEASE: ASSOCIATED RESEARCH IN EASTERN SIBERIA POPULATIONS2541-94202587-9596https://doaj.org/article/7296373f88384a1b8fb251f39a4acdbc2013-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1609https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Purpose: to study nutritional habits as a risk factor of cardiovascular pathology as so as a role of apolipoprotein A1 gene in metabolism in native and alien population of Eastern Siberia. Methods: we used Kiselev questionnaire (1998) for estimation of "nutritional risk". Totally 863 adolescents were evaluated, including 445 (51,6 %) persons of the alien ethnogroup (Russian) and 418 (48,4 %) persons of the native ethnogroup (Buriat). We evaluated clinically, functionally and genetically healthy and hypertensive (having essential arterial hypertension) adolescents and compared the results. Out of 226 adolescents with essential arterial hypertension, 144 persons were from the alien ethnogroup (mean age is 16,22 ± 1,14 years) and 82 adolescents from the native ethnogroup (mean age is 16,57 ± 1,62 years). Out of 173 healthy adolescents (mean age is 15,12 ± 2,71 years), 79 (45,7 %) persons were buriats and 94 (54,3 %) persons were Russian. Ethnic data were gotten by questionnaire, which included information about nationality back to the third generation of ancestors. We studied a total genomic DNA, which was extracted from blood serum by non-enzymatic method. An amplification of DNA loci was performed by polymerase-chain reaction using an automatic thermocycler «Biometra» with «SNP-экспресс», «Litex» reagents. The results of our research indicated an imbalance of nutritional habits with domination of protein-lipid dietary compounds in adolescents of native and alien population ofEastern Siberia. We found differentiated contributions ofinsertion-deletional polymorphism of apolipoprotein A1 gene. We did no found differences of frequency response of alleles and genotypes. We found a positive linkofapolipoprotein Al gene deletion with increased level ofcholesterine, very low density lipoproteins, triglycerides as so as with elevation ofnumbers ofblood pressure indexes in the adolescents ofthe alien ethnogroup. We did not found such kind of links in adolescents of the native ethnogroup that, as we suppose, may be a reflection of the evolutionary developed nutritional stereotype with some predominance oflipid-protein dietary component. Developed through the millennia such kind ofdiet in the indigenous population of the North and Siberia is a response to cold stress and underlies formation ofthe genotype, which aimed to developing a biochemical phenotype with ability to compensate this nutritional atherogenic imbalance.T. A. BairovaV. V. DolgikhL. I. KolesnikovaO. A. PervushinaScientific Сentre for Family Health and Human Reproduction Problemsarticlenutritionethnosgeneticsrisk factorsarterial hypertensionapolipoproteinburyatrussianScienceQRUActa Biomedica Scientifica, Vol 0, Iss 4, Pp 87-92 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	nutrition ethnos genetics risk factors arterial hypertension apolipoprotein buryat russian Science Q
spellingShingle	nutrition ethnos genetics risk factors arterial hypertension apolipoprotein buryat russian Science Q T. A. Bairova V. V. Dolgikh L. I. Kolesnikova O. A. Pervushina NUTRITCIOGENETICS AND RISK FACTORS OF CARDIOVASCULAR DISEASE: ASSOCIATED RESEARCH IN EASTERN SIBERIA POPULATIONS
description	Purpose: to study nutritional habits as a risk factor of cardiovascular pathology as so as a role of apolipoprotein A1 gene in metabolism in native and alien population of Eastern Siberia. Methods: we used Kiselev questionnaire (1998) for estimation of "nutritional risk". Totally 863 adolescents were evaluated, including 445 (51,6 %) persons of the alien ethnogroup (Russian) and 418 (48,4 %) persons of the native ethnogroup (Buriat). We evaluated clinically, functionally and genetically healthy and hypertensive (having essential arterial hypertension) adolescents and compared the results. Out of 226 adolescents with essential arterial hypertension, 144 persons were from the alien ethnogroup (mean age is 16,22 ± 1,14 years) and 82 adolescents from the native ethnogroup (mean age is 16,57 ± 1,62 years). Out of 173 healthy adolescents (mean age is 15,12 ± 2,71 years), 79 (45,7 %) persons were buriats and 94 (54,3 %) persons were Russian. Ethnic data were gotten by questionnaire, which included information about nationality back to the third generation of ancestors. We studied a total genomic DNA, which was extracted from blood serum by non-enzymatic method. An amplification of DNA loci was performed by polymerase-chain reaction using an automatic thermocycler «Biometra» with «SNP-экспресс», «Litex» reagents. The results of our research indicated an imbalance of nutritional habits with domination of protein-lipid dietary compounds in adolescents of native and alien population ofEastern Siberia. We found differentiated contributions ofinsertion-deletional polymorphism of apolipoprotein A1 gene. We did no found differences of frequency response of alleles and genotypes. We found a positive linkofapolipoprotein Al gene deletion with increased level ofcholesterine, very low density lipoproteins, triglycerides as so as with elevation ofnumbers ofblood pressure indexes in the adolescents ofthe alien ethnogroup. We did not found such kind of links in adolescents of the native ethnogroup that, as we suppose, may be a reflection of the evolutionary developed nutritional stereotype with some predominance oflipid-protein dietary component. Developed through the millennia such kind ofdiet in the indigenous population of the North and Siberia is a response to cold stress and underlies formation ofthe genotype, which aimed to developing a biochemical phenotype with ability to compensate this nutritional atherogenic imbalance.
format	article
author	T. A. Bairova V. V. Dolgikh L. I. Kolesnikova O. A. Pervushina
author_facet	T. A. Bairova V. V. Dolgikh L. I. Kolesnikova O. A. Pervushina
author_sort	T. A. Bairova
title	NUTRITCIOGENETICS AND RISK FACTORS OF CARDIOVASCULAR DISEASE: ASSOCIATED RESEARCH IN EASTERN SIBERIA POPULATIONS
title_short	NUTRITCIOGENETICS AND RISK FACTORS OF CARDIOVASCULAR DISEASE: ASSOCIATED RESEARCH IN EASTERN SIBERIA POPULATIONS
title_full	NUTRITCIOGENETICS AND RISK FACTORS OF CARDIOVASCULAR DISEASE: ASSOCIATED RESEARCH IN EASTERN SIBERIA POPULATIONS
title_fullStr	NUTRITCIOGENETICS AND RISK FACTORS OF CARDIOVASCULAR DISEASE: ASSOCIATED RESEARCH IN EASTERN SIBERIA POPULATIONS
title_full_unstemmed	NUTRITCIOGENETICS AND RISK FACTORS OF CARDIOVASCULAR DISEASE: ASSOCIATED RESEARCH IN EASTERN SIBERIA POPULATIONS
title_sort	nutritciogenetics and risk factors of cardiovascular disease: associated research in eastern siberia populations
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/7296373f88384a1b8fb251f39a4acdbc
work_keys_str_mv	AT tabairova nutritciogeneticsandriskfactorsofcardiovasculardiseaseassociatedresearchineasternsiberiapopulations AT vvdolgikh nutritciogeneticsandriskfactorsofcardiovasculardiseaseassociatedresearchineasternsiberiapopulations AT likolesnikova nutritciogeneticsandriskfactorsofcardiovasculardiseaseassociatedresearchineasternsiberiapopulations AT oapervushina nutritciogeneticsandriskfactorsofcardiovasculardiseaseassociatedresearchineasternsiberiapopulations
_version_	1718417138725683200

NUTRITCIOGENETICS AND RISK FACTORS OF CARDIOVASCULAR DISEASE: ASSOCIATED RESEARCH IN EASTERN SIBERIA POPULATIONS

Ejemplares similares