Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients

Abstract Diffuse low-grade gliomas (DLGGs) growing on the insular lobe induce contralesional hemispheric insular lobe compensation of damaged functioning by increasing cortical volumes. However, it remains unclear how functional networks are altered in patients with insular lobe DLGGs during functio...

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Autores principales:	Shengyu Fang, Chunyao Zhou, Yinyan Wang, Tao Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/729658caf0ff4c3e89c555587d5d13e9
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spelling	oai:doaj.org-article:729658caf0ff4c3e89c555587d5d13e92021-12-02T14:12:43ZContralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients10.1038/s41598-020-79845-32045-2322https://doaj.org/article/729658caf0ff4c3e89c555587d5d13e92021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79845-3https://doaj.org/toc/2045-2322Abstract Diffuse low-grade gliomas (DLGGs) growing on the insular lobe induce contralesional hemispheric insular lobe compensation of damaged functioning by increasing cortical volumes. However, it remains unclear how functional networks are altered in patients with insular lobe DLGGs during functional compensation. Thirty-five patients with insular DLGGs were classified into the left (insL, n = 16) and right groups (insR, n = 19), and 33 healthy subjects were included in the control group. Resting state functional magnetic resonance imaging was used to generate functional connectivity (FC), and network topological properties were evaluated using graph theoretical analysis based on FC matrices. Network-based statistics were applied to compare differences in the FC matrices. A false discovery rate was applied to correct the topological properties. There was no difference in the FC of edges between the control and insL groups; however, the nodal shortest path length of the right insular lobe was significantly increased in the insL group compared to the control group. Additionally, FC was increased in the functional edges originating from the left insular lobe in the insR group compared to the control group. Moreover, there were no differences in topological properties between the insR and control groups. The contralesional insular lobe is crucial for network alterations. The detailed patterns of network alterations were different depending on the affected hemisphere. The observed network alterations might be associated with functional network reorganization and functional compensation.Shengyu FangChunyao ZhouYinyan WangTao JiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shengyu Fang Chunyao Zhou Yinyan Wang Tao Jiang Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients
description	Abstract Diffuse low-grade gliomas (DLGGs) growing on the insular lobe induce contralesional hemispheric insular lobe compensation of damaged functioning by increasing cortical volumes. However, it remains unclear how functional networks are altered in patients with insular lobe DLGGs during functional compensation. Thirty-five patients with insular DLGGs were classified into the left (insL, n = 16) and right groups (insR, n = 19), and 33 healthy subjects were included in the control group. Resting state functional magnetic resonance imaging was used to generate functional connectivity (FC), and network topological properties were evaluated using graph theoretical analysis based on FC matrices. Network-based statistics were applied to compare differences in the FC matrices. A false discovery rate was applied to correct the topological properties. There was no difference in the FC of edges between the control and insL groups; however, the nodal shortest path length of the right insular lobe was significantly increased in the insL group compared to the control group. Additionally, FC was increased in the functional edges originating from the left insular lobe in the insR group compared to the control group. Moreover, there were no differences in topological properties between the insR and control groups. The contralesional insular lobe is crucial for network alterations. The detailed patterns of network alterations were different depending on the affected hemisphere. The observed network alterations might be associated with functional network reorganization and functional compensation.
format	article
author	Shengyu Fang Chunyao Zhou Yinyan Wang Tao Jiang
author_facet	Shengyu Fang Chunyao Zhou Yinyan Wang Tao Jiang
author_sort	Shengyu Fang
title	Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients
title_short	Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients
title_full	Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients
title_fullStr	Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients
title_full_unstemmed	Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients
title_sort	contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/729658caf0ff4c3e89c555587d5d13e9
work_keys_str_mv	AT shengyufang contralesionalfunctionalnetworkreorganizationoftheinsularcortexindiffuselowgradegliomapatients AT chunyaozhou contralesionalfunctionalnetworkreorganizationoftheinsularcortexindiffuselowgradegliomapatients AT yinyanwang contralesionalfunctionalnetworkreorganizationoftheinsularcortexindiffuselowgradegliomapatients AT taojiang contralesionalfunctionalnetworkreorganizationoftheinsularcortexindiffuselowgradegliomapatients
_version_	1718391790153760768

Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients

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