Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer

Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer

Bone metastasis is a major complication of breast cancer (BC) and ER+ tumors have a higher incidence of bone metastasis than ER− tumors. Here, the authors report that miR‐19a in exosomes and the bone matrix protein, IBSP, are upregulated and secreted by bone tropic ER+ BC cells, where they cooperati...

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Autores principales: Kerui Wu, Jiamei Feng, Feng Lyu, Fei Xing, Sambad Sharma, Yin Liu, Shih-Ying Wu, Dan Zhao, Abhishek Tyagi, Ravindra Pramod Deshpande, Xinhong Pei, Marco Gabril Ruiz, Hiroyuki Takahashi, Shunsuke Tsuzuki, Takahiro Kimura, Yin-yuan Mo, Yusuke Shiozawa, Ravi Singh, Kounosuke Watabe
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7296b39706fa487aa5244bf2e2e92852
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spelling oai:doaj.org-article:7296b39706fa487aa5244bf2e2e928522021-12-02T19:10:44ZExosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer10.1038/s41467-021-25473-y2041-1723https://doaj.org/article/7296b39706fa487aa5244bf2e2e928522021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25473-yhttps://doaj.org/toc/2041-1723Bone metastasis is a major complication of breast cancer (BC) and ER+ tumors have a higher incidence of bone metastasis than ER− tumors. Here, the authors report that miR‐19a in exosomes and the bone matrix protein, IBSP, are upregulated and secreted by bone tropic ER+ BC cells, where they cooperatively induce osteoclastogenesis and promote bone colonization.Kerui WuJiamei FengFeng LyuFei XingSambad SharmaYin LiuShih-Ying WuDan ZhaoAbhishek TyagiRavindra Pramod DeshpandeXinhong PeiMarco Gabril RuizHiroyuki TakahashiShunsuke TsuzukiTakahiro KimuraYin-yuan MoYusuke ShiozawaRavi SinghKounosuke WatabeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kerui Wu
Jiamei Feng
Feng Lyu
Fei Xing
Sambad Sharma
Yin Liu
Shih-Ying Wu
Dan Zhao
Abhishek Tyagi
Ravindra Pramod Deshpande
Xinhong Pei
Marco Gabril Ruiz
Hiroyuki Takahashi
Shunsuke Tsuzuki
Takahiro Kimura
Yin-yuan Mo
Yusuke Shiozawa
Ravi Singh
Kounosuke Watabe
Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer
description Bone metastasis is a major complication of breast cancer (BC) and ER+ tumors have a higher incidence of bone metastasis than ER− tumors. Here, the authors report that miR‐19a in exosomes and the bone matrix protein, IBSP, are upregulated and secreted by bone tropic ER+ BC cells, where they cooperatively induce osteoclastogenesis and promote bone colonization.
format article
author Kerui Wu
Jiamei Feng
Feng Lyu
Fei Xing
Sambad Sharma
Yin Liu
Shih-Ying Wu
Dan Zhao
Abhishek Tyagi
Ravindra Pramod Deshpande
Xinhong Pei
Marco Gabril Ruiz
Hiroyuki Takahashi
Shunsuke Tsuzuki
Takahiro Kimura
Yin-yuan Mo
Yusuke Shiozawa
Ravi Singh
Kounosuke Watabe
author_facet Kerui Wu
Jiamei Feng
Feng Lyu
Fei Xing
Sambad Sharma
Yin Liu
Shih-Ying Wu
Dan Zhao
Abhishek Tyagi
Ravindra Pramod Deshpande
Xinhong Pei
Marco Gabril Ruiz
Hiroyuki Takahashi
Shunsuke Tsuzuki
Takahiro Kimura
Yin-yuan Mo
Yusuke Shiozawa
Ravi Singh
Kounosuke Watabe
author_sort Kerui Wu
title Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer
title_short Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer
title_full Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer
title_fullStr Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer
title_full_unstemmed Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer
title_sort exosomal mir-19a and ibsp cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7296b39706fa487aa5244bf2e2e92852
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