Glioblastoma multiforme metastasizing to the skin, a case report and literature review

Glioblastoma Multiforme (GBM) is the most common primary central nervous system (CNS) malignancy in adults. It is very aggressive and is notorious for its fast and local invasion of nearby brain parenchyma. Consequently, the overall survival (OS) of patients with GBM is short despite resection, radi...

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Autores principales:	Clara El Nakib, Rayan Hajjar, Maroun Bou Zerdan, Hussein Darwish, Youssef Zeidan, Saada Alame, Hala Kfoury Kassouf, Nathalie Chamseddine, Hazem I. Assi, MD
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	CNS (Central Nervous System) Glioblastoma Multiforme (GBM) Metastasis Skin Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/729955936c1d428c9ee9642486f7b044
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spelling	oai:doaj.org-article:729955936c1d428c9ee9642486f7b0442021-11-30T04:15:17ZGlioblastoma multiforme metastasizing to the skin, a case report and literature review1930-043310.1016/j.radcr.2021.10.029https://doaj.org/article/729955936c1d428c9ee9642486f7b0442022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1930043321007470https://doaj.org/toc/1930-0433Glioblastoma Multiforme (GBM) is the most common primary central nervous system (CNS) malignancy in adults. It is very aggressive and is notorious for its fast and local invasion of nearby brain parenchyma. Consequently, the overall survival (OS) of patients with GBM is short despite resection, radiotherapy and chemotherapy regimens. The most common sites of metastasis of GBM are the lungs and pleura, cervical lymph nodes, and bone. Metastasis to the skin is a rare event and to our knowledge, there are less than 30 cases of GBM metastasizing to cutaneous or subcutaneous tissue described in the literature. None of these cases were diagnosed and/or treated in the Middle East region; and the majority of the metastases found were adjacent to the site of surgery undergone to remove the primary malignancy.We present the case of a 53-year-old male diagnosed with GBM and later showing signs of metastases at the anterio-auricular side of his face near-distant from the site of previous surgery done to remove the primary tumor.Clara El NakibRayan HajjarMaroun Bou ZerdanHussein DarwishYoussef ZeidanSaada AlameHala Kfoury KassoufNathalie ChamseddineHazem I. Assi, MDElsevierarticleCNS (Central Nervous System)Glioblastoma Multiforme (GBM)MetastasisSkinMedical physics. Medical radiology. Nuclear medicineR895-920ENRadiology Case Reports, Vol 17, Iss 1, Pp 171-175 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	CNS (Central Nervous System) Glioblastoma Multiforme (GBM) Metastasis Skin Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	CNS (Central Nervous System) Glioblastoma Multiforme (GBM) Metastasis Skin Medical physics. Medical radiology. Nuclear medicine R895-920 Clara El Nakib Rayan Hajjar Maroun Bou Zerdan Hussein Darwish Youssef Zeidan Saada Alame Hala Kfoury Kassouf Nathalie Chamseddine Hazem I. Assi, MD Glioblastoma multiforme metastasizing to the skin, a case report and literature review
description	Glioblastoma Multiforme (GBM) is the most common primary central nervous system (CNS) malignancy in adults. It is very aggressive and is notorious for its fast and local invasion of nearby brain parenchyma. Consequently, the overall survival (OS) of patients with GBM is short despite resection, radiotherapy and chemotherapy regimens. The most common sites of metastasis of GBM are the lungs and pleura, cervical lymph nodes, and bone. Metastasis to the skin is a rare event and to our knowledge, there are less than 30 cases of GBM metastasizing to cutaneous or subcutaneous tissue described in the literature. None of these cases were diagnosed and/or treated in the Middle East region; and the majority of the metastases found were adjacent to the site of surgery undergone to remove the primary malignancy.We present the case of a 53-year-old male diagnosed with GBM and later showing signs of metastases at the anterio-auricular side of his face near-distant from the site of previous surgery done to remove the primary tumor.
format	article
author	Clara El Nakib Rayan Hajjar Maroun Bou Zerdan Hussein Darwish Youssef Zeidan Saada Alame Hala Kfoury Kassouf Nathalie Chamseddine Hazem I. Assi, MD
author_facet	Clara El Nakib Rayan Hajjar Maroun Bou Zerdan Hussein Darwish Youssef Zeidan Saada Alame Hala Kfoury Kassouf Nathalie Chamseddine Hazem I. Assi, MD
author_sort	Clara El Nakib
title	Glioblastoma multiforme metastasizing to the skin, a case report and literature review
title_short	Glioblastoma multiforme metastasizing to the skin, a case report and literature review
title_full	Glioblastoma multiforme metastasizing to the skin, a case report and literature review
title_fullStr	Glioblastoma multiforme metastasizing to the skin, a case report and literature review
title_full_unstemmed	Glioblastoma multiforme metastasizing to the skin, a case report and literature review
title_sort	glioblastoma multiforme metastasizing to the skin, a case report and literature review
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/729955936c1d428c9ee9642486f7b044
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Glioblastoma multiforme metastasizing to the skin, a case report and literature review

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