Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction

Elevated glucagon level in obesity and diabetes promotes hepatic glucose production and hyperglycemia. Here the authors report that NF-κB2 augments the hepatic glucagon responses by inhibiting PDE4B induction, and that metformin lowers blood glucose in part by inhibiting NF-κB2.

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Autores principales:	Wen-Song Zhang, An Pan, Xu Zhang, Ang Ying, Gaoxiang Ma, Bao-Lin Liu, Lian-Wen Qi, Qun Liu, Ping Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/729ecacced844478889cf46a40cf21c6
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spelling	oai:doaj.org-article:729ecacced844478889cf46a40cf21c62021-12-02T16:58:28ZInactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction10.1038/s41467-019-12351-x2041-1723https://doaj.org/article/729ecacced844478889cf46a40cf21c62019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12351-xhttps://doaj.org/toc/2041-1723Elevated glucagon level in obesity and diabetes promotes hepatic glucose production and hyperglycemia. Here the authors report that NF-κB2 augments the hepatic glucagon responses by inhibiting PDE4B induction, and that metformin lowers blood glucose in part by inhibiting NF-κB2.Wen-Song ZhangAn PanXu ZhangAng YingGaoxiang MaBao-Lin LiuLian-Wen QiQun LiuPing LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen-Song Zhang An Pan Xu Zhang Ang Ying Gaoxiang Ma Bao-Lin Liu Lian-Wen Qi Qun Liu Ping Li Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction
description	Elevated glucagon level in obesity and diabetes promotes hepatic glucose production and hyperglycemia. Here the authors report that NF-κB2 augments the hepatic glucagon responses by inhibiting PDE4B induction, and that metformin lowers blood glucose in part by inhibiting NF-κB2.
format	article
author	Wen-Song Zhang An Pan Xu Zhang Ang Ying Gaoxiang Ma Bao-Lin Liu Lian-Wen Qi Qun Liu Ping Li
author_facet	Wen-Song Zhang An Pan Xu Zhang Ang Ying Gaoxiang Ma Bao-Lin Liu Lian-Wen Qi Qun Liu Ping Li
author_sort	Wen-Song Zhang
title	Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction
title_short	Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction
title_full	Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction
title_fullStr	Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction
title_full_unstemmed	Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction
title_sort	inactivation of nf-κb2 (p52) restrains hepatic glucagon response via preserving pde4b induction
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/729ecacced844478889cf46a40cf21c6
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Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction

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