High frequency of psychosis in late-stage Parkinsońs disease

Background: Psychosis is a frequent non-motor symptom in Parkinson’s disease (PD). Estimates of the frequency of Parkinsońs disease psychosis (PDP) vary widely. Knowledge about the frequency and phenomenology of psychosis in late-stage (LS) PD patients is limited.This study aimed to determine the f...

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Autores principales:	Inês Chendo, Margherita Fabbri, Catarina Godinho, Rita Moiron Simões, Catarina Severiano Sousa, Miguel Coelho, Valerie Voon, Joaquim J. Ferreira
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Parkinson’s disease Late-stage Psychosis Psychiatric comorbidities Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/72a1ddcf136d4a0f8238a07d9dc6c4f1
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spelling	oai:doaj.org-article:72a1ddcf136d4a0f8238a07d9dc6c4f12021-11-28T04:37:42ZHigh frequency of psychosis in late-stage Parkinsońs disease2590-112510.1016/j.prdoa.2021.100119https://doaj.org/article/72a1ddcf136d4a0f8238a07d9dc6c4f12021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590112521000311https://doaj.org/toc/2590-1125Background: Psychosis is a frequent non-motor symptom in Parkinson’s disease (PD). Estimates of the frequency of Parkinsońs disease psychosis (PDP) vary widely. Knowledge about the frequency and phenomenology of psychosis in late-stage (LS) PD patients is limited.This study aimed to determine the frequency of psychosis in LSPD patients through clinical diagnostic interview (CDI) (gold standard), according to NINDS/NIMH diagnostic criteria for PDP. The secondary objectives were to characterize the phenomenology, to test selected instruments and assess their adequacy in comparison to CDI, and to assess the psychiatric comorbidities. Methods: A cross-sectional study including LSPD patients (patients with ≥ 7 years from symptoms onset and Hoehn and Yahr scale score > 3 or a Schwab and England scale score < 50% in the ON condition) was conducted. Patients were subjected to psychiatric, neurological, and neuropsychological evaluations. Each patient was interviewed by a psychiatrist who performed a CDI. Results: 92 LSPD patients were included. 55.4% experienced psychotic symptoms according to NINDS/NIMH diagnostic criteria for PDP. Hallucinations were present in 94.1% and delusions in 29.4% of the psychotic patients. Visual hallucinations were the most common (88.23%) psychotic symptom. 72.5% of LSPD patients with psychotic symptoms had at least one comorbid psychiatric diagnosis. Lower frequency of psychosis was found when the assessment was performed only through selected instruments rather than CDI. Conclusions: A high frequency (55.4%) of psychotic symptoms and comorbid psychiatric (72.5%) diagnosis were found in LSPD patients. The use of CDI, in addition to structured scales may increase the sensitivity of detecting psychotic symptoms.Inês ChendoMargherita FabbriCatarina GodinhoRita Moiron SimõesCatarina Severiano SousaMiguel CoelhoValerie VoonJoaquim J. FerreiraElsevierarticleParkinson’s diseaseLate-stagePsychosisPsychiatric comorbiditiesNeurology. Diseases of the nervous systemRC346-429ENClinical Parkinsonism & Related Disorders, Vol 5, Iss , Pp 100119- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease Late-stage Psychosis Psychiatric comorbidities Neurology. Diseases of the nervous system RC346-429
spellingShingle	Parkinson’s disease Late-stage Psychosis Psychiatric comorbidities Neurology. Diseases of the nervous system RC346-429 Inês Chendo Margherita Fabbri Catarina Godinho Rita Moiron Simões Catarina Severiano Sousa Miguel Coelho Valerie Voon Joaquim J. Ferreira High frequency of psychosis in late-stage Parkinsońs disease
description	Background: Psychosis is a frequent non-motor symptom in Parkinson’s disease (PD). Estimates of the frequency of Parkinsońs disease psychosis (PDP) vary widely. Knowledge about the frequency and phenomenology of psychosis in late-stage (LS) PD patients is limited.This study aimed to determine the frequency of psychosis in LSPD patients through clinical diagnostic interview (CDI) (gold standard), according to NINDS/NIMH diagnostic criteria for PDP. The secondary objectives were to characterize the phenomenology, to test selected instruments and assess their adequacy in comparison to CDI, and to assess the psychiatric comorbidities. Methods: A cross-sectional study including LSPD patients (patients with ≥ 7 years from symptoms onset and Hoehn and Yahr scale score > 3 or a Schwab and England scale score < 50% in the ON condition) was conducted. Patients were subjected to psychiatric, neurological, and neuropsychological evaluations. Each patient was interviewed by a psychiatrist who performed a CDI. Results: 92 LSPD patients were included. 55.4% experienced psychotic symptoms according to NINDS/NIMH diagnostic criteria for PDP. Hallucinations were present in 94.1% and delusions in 29.4% of the psychotic patients. Visual hallucinations were the most common (88.23%) psychotic symptom. 72.5% of LSPD patients with psychotic symptoms had at least one comorbid psychiatric diagnosis. Lower frequency of psychosis was found when the assessment was performed only through selected instruments rather than CDI. Conclusions: A high frequency (55.4%) of psychotic symptoms and comorbid psychiatric (72.5%) diagnosis were found in LSPD patients. The use of CDI, in addition to structured scales may increase the sensitivity of detecting psychotic symptoms.
format	article
author	Inês Chendo Margherita Fabbri Catarina Godinho Rita Moiron Simões Catarina Severiano Sousa Miguel Coelho Valerie Voon Joaquim J. Ferreira
author_facet	Inês Chendo Margherita Fabbri Catarina Godinho Rita Moiron Simões Catarina Severiano Sousa Miguel Coelho Valerie Voon Joaquim J. Ferreira
author_sort	Inês Chendo
title	High frequency of psychosis in late-stage Parkinsońs disease
title_short	High frequency of psychosis in late-stage Parkinsońs disease
title_full	High frequency of psychosis in late-stage Parkinsońs disease
title_fullStr	High frequency of psychosis in late-stage Parkinsońs disease
title_full_unstemmed	High frequency of psychosis in late-stage Parkinsońs disease
title_sort	high frequency of psychosis in late-stage parkinsońs disease
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/72a1ddcf136d4a0f8238a07d9dc6c4f1
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High frequency of psychosis in late-stage Parkinsońs disease

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