Haematological reference intervals in a multiethnic population.

<h4>Introduction</h4>Similar to other populations, full blood count reference (FBC) intervals in Malaysia are generally derived from non-Malaysian subjects. However, numerous studies have shown significant differences between and within populations supporting the need for population spec...

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Autores principales:	Angeli Ambayya, Anselm Ting Su, Nadila Haryani Osman, Nik Rosnita Nik-Samsudin, Khadijah Khalid, Kian Meng Chang, Jameela Sathar, Jay Suriar Rajasuriar, Subramanian Yegappan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72a337a24f2647b3afc829fd23186f1c
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spelling	oai:doaj.org-article:72a337a24f2647b3afc829fd23186f1c2021-11-18T08:27:40ZHaematological reference intervals in a multiethnic population.1932-620310.1371/journal.pone.0091968https://doaj.org/article/72a337a24f2647b3afc829fd23186f1c2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24642526/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Similar to other populations, full blood count reference (FBC) intervals in Malaysia are generally derived from non-Malaysian subjects. However, numerous studies have shown significant differences between and within populations supporting the need for population specific intervals.<h4>Methods</h4>Two thousand seven hundred twenty five apparently healthy adults comprising all ages, both genders and three principal races were recruited through voluntary participation. FBC was performed on two analysers, Sysmex XE-5000 and Unicel DxH 800, in addition to blood smears and haemoglobin analysis. Serum ferritin, soluble transferrin receptor and C-reactive protein assays were performed in selected subjects. All parameters of qualified subjects were tested for normality followed by determination of reference intervals, measures of central tendency and dispersion along with point estimates for each subgroup.<h4>Results</h4>Complete data was available in 2440 subjects of whom 56% (907 women and 469 men) were included in reference interval calculation. Compared to other populations there were significant differences for haemoglobin, red blood cell count, platelet count and haematocrit in Malaysians. There were differences between men and women, and between younger and older men; unlike in other populations, haemoglobin was similar in younger and older women. However ethnicity and smoking had little impact. 70% of anemia in premenopausal women, 24% in postmenopausal women and 20% of males is attributable to iron deficiency. There was excellent correlation between Sysmex XE-5000 and Unicel DxH 800.<h4>Conclusion</h4>Our data confirms the importance of population specific haematological parameters and supports the need for local guidelines rather than adoption of generalised reference intervals and cut-offs.Angeli AmbayyaAnselm Ting SuNadila Haryani OsmanNik Rosnita Nik-SamsudinKhadijah KhalidKian Meng ChangJameela SatharJay Suriar RajasuriarSubramanian YegappanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e91968 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angeli Ambayya Anselm Ting Su Nadila Haryani Osman Nik Rosnita Nik-Samsudin Khadijah Khalid Kian Meng Chang Jameela Sathar Jay Suriar Rajasuriar Subramanian Yegappan Haematological reference intervals in a multiethnic population.
description	<h4>Introduction</h4>Similar to other populations, full blood count reference (FBC) intervals in Malaysia are generally derived from non-Malaysian subjects. However, numerous studies have shown significant differences between and within populations supporting the need for population specific intervals.<h4>Methods</h4>Two thousand seven hundred twenty five apparently healthy adults comprising all ages, both genders and three principal races were recruited through voluntary participation. FBC was performed on two analysers, Sysmex XE-5000 and Unicel DxH 800, in addition to blood smears and haemoglobin analysis. Serum ferritin, soluble transferrin receptor and C-reactive protein assays were performed in selected subjects. All parameters of qualified subjects were tested for normality followed by determination of reference intervals, measures of central tendency and dispersion along with point estimates for each subgroup.<h4>Results</h4>Complete data was available in 2440 subjects of whom 56% (907 women and 469 men) were included in reference interval calculation. Compared to other populations there were significant differences for haemoglobin, red blood cell count, platelet count and haematocrit in Malaysians. There were differences between men and women, and between younger and older men; unlike in other populations, haemoglobin was similar in younger and older women. However ethnicity and smoking had little impact. 70% of anemia in premenopausal women, 24% in postmenopausal women and 20% of males is attributable to iron deficiency. There was excellent correlation between Sysmex XE-5000 and Unicel DxH 800.<h4>Conclusion</h4>Our data confirms the importance of population specific haematological parameters and supports the need for local guidelines rather than adoption of generalised reference intervals and cut-offs.
format	article
author	Angeli Ambayya Anselm Ting Su Nadila Haryani Osman Nik Rosnita Nik-Samsudin Khadijah Khalid Kian Meng Chang Jameela Sathar Jay Suriar Rajasuriar Subramanian Yegappan
author_facet	Angeli Ambayya Anselm Ting Su Nadila Haryani Osman Nik Rosnita Nik-Samsudin Khadijah Khalid Kian Meng Chang Jameela Sathar Jay Suriar Rajasuriar Subramanian Yegappan
author_sort	Angeli Ambayya
title	Haematological reference intervals in a multiethnic population.
title_short	Haematological reference intervals in a multiethnic population.
title_full	Haematological reference intervals in a multiethnic population.
title_fullStr	Haematological reference intervals in a multiethnic population.
title_full_unstemmed	Haematological reference intervals in a multiethnic population.
title_sort	haematological reference intervals in a multiethnic population.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/72a337a24f2647b3afc829fd23186f1c
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Haematological reference intervals in a multiethnic population.

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