From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective

Isaac Ginsburg,1 Peter Vernon van Heerden,2 Erez Koren1 1Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University of Jerusalem, 2General Intensive Care Unit, Hadassah University Hospital, Jerusalem, Israel Abstract: This paper describes the evolution of our understanding of th...

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Autores principales:	Ginsburg I, van Heerden PV, Koren E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Amino acids polymers anti-microbial peptides and histones Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/72a4399056f54612b68064c8537769d0
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spelling	oai:doaj.org-article:72a4399056f54612b68064c8537769d02021-12-02T00:05:18ZFrom amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective1178-7031https://doaj.org/article/72a4399056f54612b68064c8537769d02017-02-01T00:00:00Zhttps://www.dovepress.com/from-amino-acids-polymers-antimicrobial-peptides-and-histones-to-their-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Isaac Ginsburg,1 Peter Vernon van Heerden,2 Erez Koren1 1Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University of Jerusalem, 2General Intensive Care Unit, Hadassah University Hospital, Jerusalem, Israel Abstract: This paper describes the evolution of our understanding of the biological role played by synthetic and natural antimicrobial cationic peptides and by the highly basic nuclear histones as modulators of infection, postinfectious sequelae, trauma, and coagulation phenomena. The authors discuss the effects of the synthetic polymers of basic poly α amino acids, poly l-lysine, and poly l-arginine on blood coagulation, fibrinolysis, bacterial killing, and blood vessels; the properties of natural and synthetic antimicrobial cationic peptides as potential replacements or adjuncts to antibiotics; polycations as opsonizing agents promoting endocytosis/phagocytosis; polycations and muramidases as activators of autolytic wall enzymes in bacteria, causing bacteriolysis and tissue damage; and polycations and nuclear histones as potential virulence factors and as markers of sepsis, septic shock, disseminated intravasclar coagulopathy, acute lung injury, pancreatitis, trauma, and other additional clinical disorders Keywords: histones, sepsis, septic shockGinsburg Ivan Heerden PVKoren EDove Medical PressarticleAmino acids polymersanti-microbial peptides and histonesPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 10, Pp 7-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Amino acids polymers anti-microbial peptides and histones Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Amino acids polymers anti-microbial peptides and histones Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Ginsburg I van Heerden PV Koren E From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective
description	Isaac Ginsburg,1 Peter Vernon van Heerden,2 Erez Koren1 1Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University of Jerusalem, 2General Intensive Care Unit, Hadassah University Hospital, Jerusalem, Israel Abstract: This paper describes the evolution of our understanding of the biological role played by synthetic and natural antimicrobial cationic peptides and by the highly basic nuclear histones as modulators of infection, postinfectious sequelae, trauma, and coagulation phenomena. The authors discuss the effects of the synthetic polymers of basic poly α amino acids, poly l-lysine, and poly l-arginine on blood coagulation, fibrinolysis, bacterial killing, and blood vessels; the properties of natural and synthetic antimicrobial cationic peptides as potential replacements or adjuncts to antibiotics; polycations as opsonizing agents promoting endocytosis/phagocytosis; polycations and muramidases as activators of autolytic wall enzymes in bacteria, causing bacteriolysis and tissue damage; and polycations and nuclear histones as potential virulence factors and as markers of sepsis, septic shock, disseminated intravasclar coagulopathy, acute lung injury, pancreatitis, trauma, and other additional clinical disorders Keywords: histones, sepsis, septic shock
format	article
author	Ginsburg I van Heerden PV Koren E
author_facet	Ginsburg I van Heerden PV Koren E
author_sort	Ginsburg I
title	From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective
title_short	From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective
title_full	From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective
title_fullStr	From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective
title_full_unstemmed	From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective
title_sort	from amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/72a4399056f54612b68064c8537769d0
work_keys_str_mv	AT ginsburgi fromaminoacidspolymersantimicrobialpeptidesandhistonestotheirpossibleroleinthepathogenesisofsepticshockahistoricalperspective AT vanheerdenpv fromaminoacidspolymersantimicrobialpeptidesandhistonestotheirpossibleroleinthepathogenesisofsepticshockahistoricalperspective AT korene fromaminoacidspolymersantimicrobialpeptidesandhistonestotheirpossibleroleinthepathogenesisofsepticshockahistoricalperspective
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From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective

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