Vascular factors and multiple measures of early brain health: CARDIA brain MRI study.
<h4>Objective</h4>To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF).<h4>Design</h4>Cross-sectional brain Magnetic Resonance I (MRI) study.<h4>Setting</h4>Community based cohort in three U.S. sites...
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| Autores principales: | , , , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2015
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/72a44c7e469c490184b0ca6bc0864451 |
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| Sumario: | <h4>Objective</h4>To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF).<h4>Design</h4>Cross-sectional brain Magnetic Resonance I (MRI) study.<h4>Setting</h4>Community based cohort in three U.S. sites.<h4>Participants</h4>A Caucasian and African-American sub-sample (n= 680; mean age 50.3 yrs) attending the 25 year follow-up exam of the Coronary Artery Risk Development in Young Adults Study.<h4>Primary and secondary outcomes</h4>3T brain MR images processed for quantitative estimates of: total brain (TBV) and abnormal white matter (AWM) volume; white matter fractional anisotropy (WM-FA); and gray matter cerebral blood flow (GM-CBF). Total intracranial volume is TBV plus cerebral spinal fluid (TICV). A Global Cognitive Function (GCF) score was derived from tests of speed, memory and executive function.<h4>Results</h4>Adjusting for TICV and demographic factors, current smoking was significantly associated with lower GM-CBF and TBV, and more AWM (all <0.05); SA with lower GM-CBF, WM-FA and TBV (p=0.01); increasing BMI with decreasing GM-CBF (p<0003); hypertension with lower GM-CBF, WM-FA, and TBV and higher AWM (all <0.05); and diabetes with lower TBV (p=0.007). The GCS was lower as TBV decreased, AWM increased, and WM-FA (all p<0.01).<h4>Conclusion</h4>In middle age adults, CVRF are associated with brain health, reflected in MRI measures of structure and perfusion, and cognitive functioning. These findings suggest markers of mid-life cardiovascular and brain health should be considered as indication for early intervention and future risk of late-life cerebrovascular disease and dementia. |
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