Feasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model

Abstract We tested the feasibility of pulmonary vein (PV) and left atrial (LA) posterior wall isolation using non-invasive stereotactic ablative body radiotherapy (SABR) and investigated pathological changes in irradiated lesions in a canine model. Seven male Mongrel dogs received single-fraction 33...

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Autores principales:	Ji Hyun Chang, Myung-Jin Cha, Jeong-Wook Seo, Hak Jae Kim, So-Yeon Park, Byoung Hyuck Kim, Euijae Lee, Moo-kang Kim, Hye-sun Yoon, Seil Oh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72a49c712015459ea0c1cdf01bab3256
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spelling	oai:doaj.org-article:72a49c712015459ea0c1cdf01bab32562021-12-02T17:48:00ZFeasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model10.1038/s41598-021-91660-y2045-2322https://doaj.org/article/72a49c712015459ea0c1cdf01bab32562021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91660-yhttps://doaj.org/toc/2045-2322Abstract We tested the feasibility of pulmonary vein (PV) and left atrial (LA) posterior wall isolation using non-invasive stereotactic ablative body radiotherapy (SABR) and investigated pathological changes in irradiated lesions in a canine model. Seven male Mongrel dogs received single-fraction 33 Gy SABR. We designed the en-bloc circular target of total PVs and LA posterior wall to avoid the esophagus. The circular box lesion included the LA roof and ridge, low posterior wall, and posterior interatrial septum. At 6 weeks or 4 months post-SABR, electrical isolation of the SABR lesion was confirmed using LA posterior wall pacing, and histopathological review was performed. Electrical isolation of all PVs and the LA posterior wall was achieved in three of five dogs in the 4-month group. There was one target failure and one sudden death at 15 weeks. Although two dogs in the 6-week group failed to achieve electrical lesion isolation, the irradiated atrial myocardium showed diffuse hemorrhage with inflammatory cell infiltration. In successfully isolated 4-month model dogs, we observed transmural fibrotic scarring with extensive fibrosis on irradiated atrial tissue. The findings suggest that this novel circular box-design radiotherapy technique using SABR could be applied to humans after further studies are conducted to confirm safety.Ji Hyun ChangMyung-Jin ChaJeong-Wook SeoHak Jae KimSo-Yeon ParkByoung Hyuck KimEuijae LeeMoo-kang KimHye-sun YoonSeil OhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ji Hyun Chang Myung-Jin Cha Jeong-Wook Seo Hak Jae Kim So-Yeon Park Byoung Hyuck Kim Euijae Lee Moo-kang Kim Hye-sun Yoon Seil Oh Feasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model
description	Abstract We tested the feasibility of pulmonary vein (PV) and left atrial (LA) posterior wall isolation using non-invasive stereotactic ablative body radiotherapy (SABR) and investigated pathological changes in irradiated lesions in a canine model. Seven male Mongrel dogs received single-fraction 33 Gy SABR. We designed the en-bloc circular target of total PVs and LA posterior wall to avoid the esophagus. The circular box lesion included the LA roof and ridge, low posterior wall, and posterior interatrial septum. At 6 weeks or 4 months post-SABR, electrical isolation of the SABR lesion was confirmed using LA posterior wall pacing, and histopathological review was performed. Electrical isolation of all PVs and the LA posterior wall was achieved in three of five dogs in the 4-month group. There was one target failure and one sudden death at 15 weeks. Although two dogs in the 6-week group failed to achieve electrical lesion isolation, the irradiated atrial myocardium showed diffuse hemorrhage with inflammatory cell infiltration. In successfully isolated 4-month model dogs, we observed transmural fibrotic scarring with extensive fibrosis on irradiated atrial tissue. The findings suggest that this novel circular box-design radiotherapy technique using SABR could be applied to humans after further studies are conducted to confirm safety.
format	article
author	Ji Hyun Chang Myung-Jin Cha Jeong-Wook Seo Hak Jae Kim So-Yeon Park Byoung Hyuck Kim Euijae Lee Moo-kang Kim Hye-sun Yoon Seil Oh
author_facet	Ji Hyun Chang Myung-Jin Cha Jeong-Wook Seo Hak Jae Kim So-Yeon Park Byoung Hyuck Kim Euijae Lee Moo-kang Kim Hye-sun Yoon Seil Oh
author_sort	Ji Hyun Chang
title	Feasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model
title_short	Feasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model
title_full	Feasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model
title_fullStr	Feasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model
title_full_unstemmed	Feasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model
title_sort	feasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/72a49c712015459ea0c1cdf01bab3256
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Feasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model

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