Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons

In neurons, the microtubule cytoskeleton provides support and directionality of axons. Here, the authors report that microtubule dynamics in axons may be regulated by the autophagy proteins (ATGs) independently of their known role in autophagy.

Guardado en:

Detalles Bibliográficos
Autores principales:	A. Negrete-Hurtado, M. Overhoff, S. Bera, E. De Bruyckere, K. Schätzmüller, M. J. Kye, C. Qin, M. Lammers, V. Kondylis, I. Neundorf, N. L. Kononenko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/72accded71bb43fdaf15240e81ebccdb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:72accded71bb43fdaf15240e81ebccdb
record_format	dspace
spelling	oai:doaj.org-article:72accded71bb43fdaf15240e81ebccdb2021-12-02T17:32:58ZAutophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons10.1038/s41467-020-15287-92041-1723https://doaj.org/article/72accded71bb43fdaf15240e81ebccdb2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15287-9https://doaj.org/toc/2041-1723In neurons, the microtubule cytoskeleton provides support and directionality of axons. Here, the authors report that microtubule dynamics in axons may be regulated by the autophagy proteins (ATGs) independently of their known role in autophagy.A. Negrete-HurtadoM. OverhoffS. BeraE. De BruyckereK. SchätzmüllerM. J. KyeC. QinM. LammersV. KondylisI. NeundorfN. L. KononenkoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Negrete-Hurtado M. Overhoff S. Bera E. De Bruyckere K. Schätzmüller M. J. Kye C. Qin M. Lammers V. Kondylis I. Neundorf N. L. Kononenko Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons
description	In neurons, the microtubule cytoskeleton provides support and directionality of axons. Here, the authors report that microtubule dynamics in axons may be regulated by the autophagy proteins (ATGs) independently of their known role in autophagy.
format	article
author	A. Negrete-Hurtado M. Overhoff S. Bera E. De Bruyckere K. Schätzmüller M. J. Kye C. Qin M. Lammers V. Kondylis I. Neundorf N. L. Kononenko
author_facet	A. Negrete-Hurtado M. Overhoff S. Bera E. De Bruyckere K. Schätzmüller M. J. Kye C. Qin M. Lammers V. Kondylis I. Neundorf N. L. Kononenko
author_sort	A. Negrete-Hurtado
title	Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons
title_short	Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons
title_full	Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons
title_fullStr	Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons
title_full_unstemmed	Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons
title_sort	autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/72accded71bb43fdaf15240e81ebccdb
work_keys_str_mv	AT anegretehurtado autophagylipidationmachineryregulatesaxonalmicrotubuledynamicsbutisdispensableforsurvivalofmammalianneurons AT moverhoff autophagylipidationmachineryregulatesaxonalmicrotubuledynamicsbutisdispensableforsurvivalofmammalianneurons AT sbera autophagylipidationmachineryregulatesaxonalmicrotubuledynamicsbutisdispensableforsurvivalofmammalianneurons AT edebruyckere autophagylipidationmachineryregulatesaxonalmicrotubuledynamicsbutisdispensableforsurvivalofmammalianneurons AT kschatzmuller autophagylipidationmachineryregulatesaxonalmicrotubuledynamicsbutisdispensableforsurvivalofmammalianneurons AT mjkye autophagylipidationmachineryregulatesaxonalmicrotubuledynamicsbutisdispensableforsurvivalofmammalianneurons AT cqin autophagylipidationmachineryregulatesaxonalmicrotubuledynamicsbutisdispensableforsurvivalofmammalianneurons AT mlammers autophagylipidationmachineryregulatesaxonalmicrotubuledynamicsbutisdispensableforsurvivalofmammalianneurons AT vkondylis autophagylipidationmachineryregulatesaxonalmicrotubuledynamicsbutisdispensableforsurvivalofmammalianneurons AT ineundorf autophagylipidationmachineryregulatesaxonalmicrotubuledynamicsbutisdispensableforsurvivalofmammalianneurons AT nlkononenko autophagylipidationmachineryregulatesaxonalmicrotubuledynamicsbutisdispensableforsurvivalofmammalianneurons
_version_	1718380127407046656

Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons

Ejemplares similares