Oral exposure to arsenic causes hearing loss in young people aged 12–29 years and in young mice
Abstract There is no information on the association between oral exposure to arsenic (As) and hearing loss in humans or mice. In this combined epidemiological study and experimental study, the association of oral exposure to As with hearing loss in people aged 12–29 years and young mice was examined...
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2017
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oai:doaj.org-article:72afc66075af41319ffb36577daa35822021-12-02T12:32:42ZOral exposure to arsenic causes hearing loss in young people aged 12–29 years and in young mice10.1038/s41598-017-06096-02045-2322https://doaj.org/article/72afc66075af41319ffb36577daa35822017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06096-0https://doaj.org/toc/2045-2322Abstract There is no information on the association between oral exposure to arsenic (As) and hearing loss in humans or mice. In this combined epidemiological study and experimental study, the association of oral exposure to As with hearing loss in people aged 12–29 years and young mice was examined. Subjects in the exposure group (n = 48), who were drinking tube well water contaminated with As, showed significantly higher risks of hearing loss at 4 kHz [odds ratio (OR) = 7.60; 95% confidence interval (CI): 1.56, 57.88], 8 kHz (OR = 5.00; 95% CI: 1.48, 18.90) and 12 kHz (OR = 8.72; 95% CI: 2.09, 47.77) than did subjects in the control group (n = 29). We next performed an experiment in which young mice were exposed to As via drinking water at 22.5 mg/L, which is a much greater concentration than that in human studies. The exposure group showed hearing loss and accumulation of As in inner ears. Ex vivo exposure of the organ of Corti from mice exposed to As significantly decreased the number of auditory neurons and fibers. Thus, our combined study showed that oral exposure to As caused hearing loss in young people and young mice.Xiang LiNobutaka OhgamiYasuhiro OmataIchiro YajimaMachiko IidaReina OshinoShoko OhnumaNazmul AhsanAnwarul Azim AkhandMasashi KatoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
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Medicine R Science Q Xiang Li Nobutaka Ohgami Yasuhiro Omata Ichiro Yajima Machiko Iida Reina Oshino Shoko Ohnuma Nazmul Ahsan Anwarul Azim Akhand Masashi Kato Oral exposure to arsenic causes hearing loss in young people aged 12–29 years and in young mice |
| description |
Abstract There is no information on the association between oral exposure to arsenic (As) and hearing loss in humans or mice. In this combined epidemiological study and experimental study, the association of oral exposure to As with hearing loss in people aged 12–29 years and young mice was examined. Subjects in the exposure group (n = 48), who were drinking tube well water contaminated with As, showed significantly higher risks of hearing loss at 4 kHz [odds ratio (OR) = 7.60; 95% confidence interval (CI): 1.56, 57.88], 8 kHz (OR = 5.00; 95% CI: 1.48, 18.90) and 12 kHz (OR = 8.72; 95% CI: 2.09, 47.77) than did subjects in the control group (n = 29). We next performed an experiment in which young mice were exposed to As via drinking water at 22.5 mg/L, which is a much greater concentration than that in human studies. The exposure group showed hearing loss and accumulation of As in inner ears. Ex vivo exposure of the organ of Corti from mice exposed to As significantly decreased the number of auditory neurons and fibers. Thus, our combined study showed that oral exposure to As caused hearing loss in young people and young mice. |
| format |
article |
| author |
Xiang Li Nobutaka Ohgami Yasuhiro Omata Ichiro Yajima Machiko Iida Reina Oshino Shoko Ohnuma Nazmul Ahsan Anwarul Azim Akhand Masashi Kato |
| author_facet |
Xiang Li Nobutaka Ohgami Yasuhiro Omata Ichiro Yajima Machiko Iida Reina Oshino Shoko Ohnuma Nazmul Ahsan Anwarul Azim Akhand Masashi Kato |
| author_sort |
Xiang Li |
| title |
Oral exposure to arsenic causes hearing loss in young people aged 12–29 years and in young mice |
| title_short |
Oral exposure to arsenic causes hearing loss in young people aged 12–29 years and in young mice |
| title_full |
Oral exposure to arsenic causes hearing loss in young people aged 12–29 years and in young mice |
| title_fullStr |
Oral exposure to arsenic causes hearing loss in young people aged 12–29 years and in young mice |
| title_full_unstemmed |
Oral exposure to arsenic causes hearing loss in young people aged 12–29 years and in young mice |
| title_sort |
oral exposure to arsenic causes hearing loss in young people aged 12–29 years and in young mice |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/72afc66075af41319ffb36577daa3582 |
| work_keys_str_mv |
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