Prefilled certolizumab pegol (Cimzia®) syringes for self-use in the treatment of rheumatoid arthritis
J Rosa1,2, M Sabelli1,2, Enrique R Soriano1,21Rheumatology Section, Internal Medical Services, Hospital Italiano de Buenos Aires, and Fundacion P.M. Catoggio para el progreso de la Reumatologia; 2University Institute, School of Medicine, Hospital Italiano de Buenos Aires, ArgentinaAbstract: A new an...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2010
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/72b0760dc5a844239758bc6769708c53 |
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| Sumario: | J Rosa1,2, M Sabelli1,2, Enrique R Soriano1,21Rheumatology Section, Internal Medical Services, Hospital Italiano de Buenos Aires, and Fundacion P.M. Catoggio para el progreso de la Reumatologia; 2University Institute, School of Medicine, Hospital Italiano de Buenos Aires, ArgentinaAbstract: A new anti-tumor necrosis factor alpha (TNF-a) inhibitor with a novel mechanism of action has entered phase 3 trials in rheumatoid arthritis (RA). Certolizumab pegol (Cimzia®) is a humanized Fab' antibody fragment against TNF-a with a polyethylene glycol tail that prevents complement-dependent and antibody-dependent cell-mediated cytotoxicity or apoptosis. Four randomized clinical trials have been published so far. Reported results are similar to those published in previous studies with other TNF-a inhibitors, with ACR20, ACR50, and ACR70 responses of around 60%, 40%, and 20%, respectively, when combined with methotrexate and slightly lower when used as monotherapy. Safety was shown to be similar to that seen with TNF-a blockers and some cases of tuberculosis were seen in the trials, stressing the importance of a complete screening in these patients. Although we still need effectiveness and safety data in larger numbers of patients and longer follow-up, this new TNF inhibitor is a welcome addition to our current armamentarium for the treatment of RA.Keywords: certolizumab pegol, rheumatoid arthritis therapy, biologic therapies |
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