Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system

Abstract The traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T2 relaxation data to calculate the myelin water fraction (MWF). A fundamentally different approach, abbreviated “mcDESPOT”, uses a more efficient steady-state a...

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Autores principales:	Adam V. Dvorak, Emil Ljungberg, Irene M. Vavasour, Lisa Eunyoung Lee, Shawna Abel, David K. B. Li, Anthony Traboulsee, Alex L. MacKay, Shannon H. Kolind
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72b25060dfcd4ad49c4b222ee0d958db
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spelling	oai:doaj.org-article:72b25060dfcd4ad49c4b222ee0d958db2021-12-02T14:01:35ZComparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system10.1038/s41598-020-80585-72045-2322https://doaj.org/article/72b25060dfcd4ad49c4b222ee0d958db2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80585-7https://doaj.org/toc/2045-2322Abstract The traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T2 relaxation data to calculate the myelin water fraction (MWF). A fundamentally different approach, abbreviated “mcDESPOT”, uses a more efficient steady-state acquisition to generate an equivalent metric (fM). Although previous studies have demonstrated inherent instability and bias in the complex mcDESPOT analysis procedure, fM has often been used as a surrogate for MWF. We produced and compared multivariate atlases of MWF and fM in healthy human brain and cervical spinal cord (available online) and compared their ability to detect multiple sclerosis pathology. A significant bias was found in all regions (p < 10–5), albeit reversed for spinal cord (fM-MWF = − 3.4%) compared to brain (+ 6.2%). MWF and fM followed an approximately linear relationship for regions with MWF < ~ 10%. For MWF > ~ 10%, the relationship broke down and fM no longer increased in tandem with MWF. For multiple sclerosis patients, MWF and fM Z score maps showed overlapping areas of low Z score and similar trends between patients and brain regions, although those of fM generally had greater spatial extent and magnitude of severity. These results will guide future choice of myelin-sensitive quantitative MRI and improve interpretation of studies using either myelin imaging approach.Adam V. DvorakEmil LjungbergIrene M. VavasourLisa Eunyoung LeeShawna AbelDavid K. B. LiAnthony TraboulseeAlex L. MacKayShannon H. KolindNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Adam V. Dvorak Emil Ljungberg Irene M. Vavasour Lisa Eunyoung Lee Shawna Abel David K. B. Li Anthony Traboulsee Alex L. MacKay Shannon H. Kolind Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system
description	Abstract The traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T2 relaxation data to calculate the myelin water fraction (MWF). A fundamentally different approach, abbreviated “mcDESPOT”, uses a more efficient steady-state acquisition to generate an equivalent metric (fM). Although previous studies have demonstrated inherent instability and bias in the complex mcDESPOT analysis procedure, fM has often been used as a surrogate for MWF. We produced and compared multivariate atlases of MWF and fM in healthy human brain and cervical spinal cord (available online) and compared their ability to detect multiple sclerosis pathology. A significant bias was found in all regions (p < 10–5), albeit reversed for spinal cord (fM-MWF = − 3.4%) compared to brain (+ 6.2%). MWF and fM followed an approximately linear relationship for regions with MWF < ~ 10%. For MWF > ~ 10%, the relationship broke down and fM no longer increased in tandem with MWF. For multiple sclerosis patients, MWF and fM Z score maps showed overlapping areas of low Z score and similar trends between patients and brain regions, although those of fM generally had greater spatial extent and magnitude of severity. These results will guide future choice of myelin-sensitive quantitative MRI and improve interpretation of studies using either myelin imaging approach.
format	article
author	Adam V. Dvorak Emil Ljungberg Irene M. Vavasour Lisa Eunyoung Lee Shawna Abel David K. B. Li Anthony Traboulsee Alex L. MacKay Shannon H. Kolind
author_facet	Adam V. Dvorak Emil Ljungberg Irene M. Vavasour Lisa Eunyoung Lee Shawna Abel David K. B. Li Anthony Traboulsee Alex L. MacKay Shannon H. Kolind
author_sort	Adam V. Dvorak
title	Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system
title_short	Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system
title_full	Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system
title_fullStr	Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system
title_full_unstemmed	Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system
title_sort	comparison of multi echo t2 relaxation and steady state approaches for myelin imaging in the central nervous system
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/72b25060dfcd4ad49c4b222ee0d958db
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Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system

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