Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia.

Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia.

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<h4>Background</h4>Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to th...

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Autores principales: Osama M Al-Amer, Atif Abdulwahab A Oyouni, Mohammed Ali Alshehri, Abdulrahman Alasmari, Othman R Alzahrani, Saad Ali S Aljohani, Noura Alasmael, Abdulrahman Theyab, Mohammad Algahtani, Hadeel Al Sadoun, Khalaf F Alsharif, Abdullah Hamad, Wed A Abdali, Yousef MohammedRabaa Hawasawi
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/72b2fdf5cbf24a43991d7121599579c5
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Sumario:<h4>Background</h4>Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to the WHO. Environmental and genetic factors play a crucial role in the development of IDA; genetic testing has revealed the association of a number of polymorphisms with iron status and serum ferritin.<h4>Aim</h4>The current study aims to reveal the association of TMPRSS6 rs141312 and BMP2 rs235756 with the iron status of females in Saudi Arabia.<h4>Methods</h4>A cohort of 108 female university students aged 18-25 years was randomly selected to participate: 50 healthy and 58 classified as iron deficient. A 3-5 mL sample of blood was collected from each one and analyzed based on hematological and biochemical iron status followed by genotyping by PCR.<h4>Results</h4>The genotype distribution of TMPRSS6 rs141312 was 8% (TT), 88% (TC) and 4% (CC) in the healthy group compared with 3.45% (TT), 89.66% (TC) and 6.89% (CC) in the iron-deficient group (P = 0.492), an insignificant difference in the allelic distribution. The genotype distribution of BMP2 rs235756 was 8% (TT), 90% (TC) and 2% (CC) in the healthy group compared with 3.45% (TT), 82.76% (TC) and 13.79% (CC) in iron-deficient group (P = 0.050) and was significantly associated with decreased ferritin status (P = 0.050). In addition, TMPRSS6 rs141312 is significantly (P<0.001) associated with dominant genotypes (TC+CC) and increased risk of IDA while BMP2 rs235756 is significantly (P<0.026) associated with recessive homozygote CC genotypes and increased risk of IDA.<h4>Conclusion</h4>Our finding potentially helps in the early prediction of iron deficiency in females through the genetic testing.

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