Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia.

<h4>Background</h4>Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to th...

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Autores principales:	Osama M Al-Amer, Atif Abdulwahab A Oyouni, Mohammed Ali Alshehri, Abdulrahman Alasmari, Othman R Alzahrani, Saad Ali S Aljohani, Noura Alasmael, Abdulrahman Theyab, Mohammad Algahtani, Hadeel Al Sadoun, Khalaf F Alsharif, Abdullah Hamad, Wed A Abdali, Yousef MohammedRabaa Hawasawi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72b2fdf5cbf24a43991d7121599579c5
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spelling	oai:doaj.org-article:72b2fdf5cbf24a43991d7121599579c52021-12-02T20:13:12ZAssociation of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia.1932-620310.1371/journal.pone.0257895https://doaj.org/article/72b2fdf5cbf24a43991d7121599579c52021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257895https://doaj.org/toc/1932-6203<h4>Background</h4>Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to the WHO. Environmental and genetic factors play a crucial role in the development of IDA; genetic testing has revealed the association of a number of polymorphisms with iron status and serum ferritin.<h4>Aim</h4>The current study aims to reveal the association of TMPRSS6 rs141312 and BMP2 rs235756 with the iron status of females in Saudi Arabia.<h4>Methods</h4>A cohort of 108 female university students aged 18-25 years was randomly selected to participate: 50 healthy and 58 classified as iron deficient. A 3-5 mL sample of blood was collected from each one and analyzed based on hematological and biochemical iron status followed by genotyping by PCR.<h4>Results</h4>The genotype distribution of TMPRSS6 rs141312 was 8% (TT), 88% (TC) and 4% (CC) in the healthy group compared with 3.45% (TT), 89.66% (TC) and 6.89% (CC) in the iron-deficient group (P = 0.492), an insignificant difference in the allelic distribution. The genotype distribution of BMP2 rs235756 was 8% (TT), 90% (TC) and 2% (CC) in the healthy group compared with 3.45% (TT), 82.76% (TC) and 13.79% (CC) in iron-deficient group (P = 0.050) and was significantly associated with decreased ferritin status (P = 0.050). In addition, TMPRSS6 rs141312 is significantly (P<0.001) associated with dominant genotypes (TC+CC) and increased risk of IDA while BMP2 rs235756 is significantly (P<0.026) associated with recessive homozygote CC genotypes and increased risk of IDA.<h4>Conclusion</h4>Our finding potentially helps in the early prediction of iron deficiency in females through the genetic testing.Osama M Al-AmerAtif Abdulwahab A OyouniMohammed Ali AlshehriAbdulrahman AlasmariOthman R AlzahraniSaad Ali S AljohaniNoura AlasmaelAbdulrahman TheyabMohammad AlgahtaniHadeel Al SadounKhalaf F AlsharifAbdullah HamadWed A AbdaliYousef MohammedRabaa HawasawiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0257895 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Osama M Al-Amer Atif Abdulwahab A Oyouni Mohammed Ali Alshehri Abdulrahman Alasmari Othman R Alzahrani Saad Ali S Aljohani Noura Alasmael Abdulrahman Theyab Mohammad Algahtani Hadeel Al Sadoun Khalaf F Alsharif Abdullah Hamad Wed A Abdali Yousef MohammedRabaa Hawasawi Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia.
description	<h4>Background</h4>Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to the WHO. Environmental and genetic factors play a crucial role in the development of IDA; genetic testing has revealed the association of a number of polymorphisms with iron status and serum ferritin.<h4>Aim</h4>The current study aims to reveal the association of TMPRSS6 rs141312 and BMP2 rs235756 with the iron status of females in Saudi Arabia.<h4>Methods</h4>A cohort of 108 female university students aged 18-25 years was randomly selected to participate: 50 healthy and 58 classified as iron deficient. A 3-5 mL sample of blood was collected from each one and analyzed based on hematological and biochemical iron status followed by genotyping by PCR.<h4>Results</h4>The genotype distribution of TMPRSS6 rs141312 was 8% (TT), 88% (TC) and 4% (CC) in the healthy group compared with 3.45% (TT), 89.66% (TC) and 6.89% (CC) in the iron-deficient group (P = 0.492), an insignificant difference in the allelic distribution. The genotype distribution of BMP2 rs235756 was 8% (TT), 90% (TC) and 2% (CC) in the healthy group compared with 3.45% (TT), 82.76% (TC) and 13.79% (CC) in iron-deficient group (P = 0.050) and was significantly associated with decreased ferritin status (P = 0.050). In addition, TMPRSS6 rs141312 is significantly (P<0.001) associated with dominant genotypes (TC+CC) and increased risk of IDA while BMP2 rs235756 is significantly (P<0.026) associated with recessive homozygote CC genotypes and increased risk of IDA.<h4>Conclusion</h4>Our finding potentially helps in the early prediction of iron deficiency in females through the genetic testing.
format	article
author	Osama M Al-Amer Atif Abdulwahab A Oyouni Mohammed Ali Alshehri Abdulrahman Alasmari Othman R Alzahrani Saad Ali S Aljohani Noura Alasmael Abdulrahman Theyab Mohammad Algahtani Hadeel Al Sadoun Khalaf F Alsharif Abdullah Hamad Wed A Abdali Yousef MohammedRabaa Hawasawi
author_facet	Osama M Al-Amer Atif Abdulwahab A Oyouni Mohammed Ali Alshehri Abdulrahman Alasmari Othman R Alzahrani Saad Ali S Aljohani Noura Alasmael Abdulrahman Theyab Mohammad Algahtani Hadeel Al Sadoun Khalaf F Alsharif Abdullah Hamad Wed A Abdali Yousef MohammedRabaa Hawasawi
author_sort	Osama M Al-Amer
title	Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia.
title_short	Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia.
title_full	Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia.
title_fullStr	Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia.
title_full_unstemmed	Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia.
title_sort	association of snps within tmprss6 and bmp2 genes with iron deficiency status in saudi arabia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/72b2fdf5cbf24a43991d7121599579c5
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Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia.

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