Biological Planning of Radiation Dose Based on In Vivo Dosimetry for Postoperative Vaginal-Cuff HDR Interventional Radiotherapy (Brachytherapy)

(1) Background: Postoperative vaginal-cuff HDR interventional radiotherapy (brachytherapy) is a standard treatment in early-stage endometrial cancer. This study reports the effect of in vivo dosimetry-based biological planning for two different fractionation schedules on the treatment-related toxici...

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Autores principales:	Tamer Soror, Ramin Chafii, Valentina Lancellotta, Luca Tagliaferri, György Kovács
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	interventional radiotherapy vaginal-cuff brachytherapy HDR brachytherapy in vivo dosimetry endometrial cancer biological planning Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/72b51afaad9743568ded63bddfb66880
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spelling	oai:doaj.org-article:72b51afaad9743568ded63bddfb668802021-11-25T16:49:47ZBiological Planning of Radiation Dose Based on In Vivo Dosimetry for Postoperative Vaginal-Cuff HDR Interventional Radiotherapy (Brachytherapy)10.3390/biomedicines91116292227-9059https://doaj.org/article/72b51afaad9743568ded63bddfb668802021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1629https://doaj.org/toc/2227-9059(1) Background: Postoperative vaginal-cuff HDR interventional radiotherapy (brachytherapy) is a standard treatment in early-stage endometrial cancer. This study reports the effect of in vivo dosimetry-based biological planning for two different fractionation schedules on the treatment-related toxicities. (2) Methods: 121 patients were treated. Group A (82) received 21 Gy in three fractions. Group B (39) received 20 Gy in four fractions. The dose was prescribed at a 5 mm depth or to the applicator surface according to the distance between the applicator and the rectum. In vivo dosimetry measured the dose of the rectum and/or urinary bladder. With a high measured dose, the dose prescription was changed from a 5 mm depth to the applicator surface. (3) Results: The median age was 66 years with 58.8 months mean follow-up. The dose prescription was changed in 20.7% of group A and in 41% of group B. Most toxicities were grade 1–2. Acute urinary toxicities were significantly higher in group A. The rates of acute and late urinary toxicities were significantly higher with a mean bladder dose/fraction of >2.5 Gy and a total bladder dose of >7.5 Gy. One patient had a vaginal recurrence. (4) Conclusions: Both schedules have excellent local control and acceptable rates of toxicities. Using in vivo dosimetry-based biological planning yielded an acceptable dose to the bladder and rectum.Tamer SororRamin ChafiiValentina LancellottaLuca TagliaferriGyörgy KovácsMDPI AGarticleinterventional radiotherapyvaginal-cuff brachytherapyHDR brachytherapyin vivo dosimetryendometrial cancerbiological planningBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1629, p 1629 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interventional radiotherapy vaginal-cuff brachytherapy HDR brachytherapy in vivo dosimetry endometrial cancer biological planning Biology (General) QH301-705.5
spellingShingle	interventional radiotherapy vaginal-cuff brachytherapy HDR brachytherapy in vivo dosimetry endometrial cancer biological planning Biology (General) QH301-705.5 Tamer Soror Ramin Chafii Valentina Lancellotta Luca Tagliaferri György Kovács Biological Planning of Radiation Dose Based on In Vivo Dosimetry for Postoperative Vaginal-Cuff HDR Interventional Radiotherapy (Brachytherapy)
description	(1) Background: Postoperative vaginal-cuff HDR interventional radiotherapy (brachytherapy) is a standard treatment in early-stage endometrial cancer. This study reports the effect of in vivo dosimetry-based biological planning for two different fractionation schedules on the treatment-related toxicities. (2) Methods: 121 patients were treated. Group A (82) received 21 Gy in three fractions. Group B (39) received 20 Gy in four fractions. The dose was prescribed at a 5 mm depth or to the applicator surface according to the distance between the applicator and the rectum. In vivo dosimetry measured the dose of the rectum and/or urinary bladder. With a high measured dose, the dose prescription was changed from a 5 mm depth to the applicator surface. (3) Results: The median age was 66 years with 58.8 months mean follow-up. The dose prescription was changed in 20.7% of group A and in 41% of group B. Most toxicities were grade 1–2. Acute urinary toxicities were significantly higher in group A. The rates of acute and late urinary toxicities were significantly higher with a mean bladder dose/fraction of >2.5 Gy and a total bladder dose of >7.5 Gy. One patient had a vaginal recurrence. (4) Conclusions: Both schedules have excellent local control and acceptable rates of toxicities. Using in vivo dosimetry-based biological planning yielded an acceptable dose to the bladder and rectum.
format	article
author	Tamer Soror Ramin Chafii Valentina Lancellotta Luca Tagliaferri György Kovács
author_facet	Tamer Soror Ramin Chafii Valentina Lancellotta Luca Tagliaferri György Kovács
author_sort	Tamer Soror
title	Biological Planning of Radiation Dose Based on In Vivo Dosimetry for Postoperative Vaginal-Cuff HDR Interventional Radiotherapy (Brachytherapy)
title_short	Biological Planning of Radiation Dose Based on In Vivo Dosimetry for Postoperative Vaginal-Cuff HDR Interventional Radiotherapy (Brachytherapy)
title_full	Biological Planning of Radiation Dose Based on In Vivo Dosimetry for Postoperative Vaginal-Cuff HDR Interventional Radiotherapy (Brachytherapy)
title_fullStr	Biological Planning of Radiation Dose Based on In Vivo Dosimetry for Postoperative Vaginal-Cuff HDR Interventional Radiotherapy (Brachytherapy)
title_full_unstemmed	Biological Planning of Radiation Dose Based on In Vivo Dosimetry for Postoperative Vaginal-Cuff HDR Interventional Radiotherapy (Brachytherapy)
title_sort	biological planning of radiation dose based on in vivo dosimetry for postoperative vaginal-cuff hdr interventional radiotherapy (brachytherapy)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/72b51afaad9743568ded63bddfb66880
work_keys_str_mv	AT tamersoror biologicalplanningofradiationdosebasedoninvivodosimetryforpostoperativevaginalcuffhdrinterventionalradiotherapybrachytherapy AT raminchafii biologicalplanningofradiationdosebasedoninvivodosimetryforpostoperativevaginalcuffhdrinterventionalradiotherapybrachytherapy AT valentinalancellotta biologicalplanningofradiationdosebasedoninvivodosimetryforpostoperativevaginalcuffhdrinterventionalradiotherapybrachytherapy AT lucatagliaferri biologicalplanningofradiationdosebasedoninvivodosimetryforpostoperativevaginalcuffhdrinterventionalradiotherapybrachytherapy AT gyorgykovacs biologicalplanningofradiationdosebasedoninvivodosimetryforpostoperativevaginalcuffhdrinterventionalradiotherapybrachytherapy
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Biological Planning of Radiation Dose Based on In Vivo Dosimetry for Postoperative Vaginal-Cuff HDR Interventional Radiotherapy (Brachytherapy)

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