RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition

RAF family kinases transmit signals from activated RAS at the plasma membrane to downstream kinases to control cell proliferation, differentiation and survival. Here the authors shed light on the molecular mechanisms whereby small molecule RAF inhibitors induce RAS-RAF association and paradoxical RA...

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Main Authors:	Ting Jin, Hugo Lavoie, Malha Sahmi, Maud David, Christine Hilt, Amy Hammell, Marc Therrien
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/72b7a7f1b9c84f32af4cc1decc0c0c7c
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id	oai:doaj.org-article:72b7a7f1b9c84f32af4cc1decc0c0c7c
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spelling	oai:doaj.org-article:72b7a7f1b9c84f32af4cc1decc0c0c7c2021-12-02T14:42:19ZRAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition10.1038/s41467-017-01274-02041-1723https://doaj.org/article/72b7a7f1b9c84f32af4cc1decc0c0c7c2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01274-0https://doaj.org/toc/2041-1723RAF family kinases transmit signals from activated RAS at the plasma membrane to downstream kinases to control cell proliferation, differentiation and survival. Here the authors shed light on the molecular mechanisms whereby small molecule RAF inhibitors induce RAS-RAF association and paradoxical RAF activation.Ting JinHugo LavoieMalha SahmiMaud DavidChristine HiltAmy HammellMarc TherrienNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ting Jin Hugo Lavoie Malha Sahmi Maud David Christine Hilt Amy Hammell Marc Therrien RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
description	RAF family kinases transmit signals from activated RAS at the plasma membrane to downstream kinases to control cell proliferation, differentiation and survival. Here the authors shed light on the molecular mechanisms whereby small molecule RAF inhibitors induce RAS-RAF association and paradoxical RAF activation.
format	article
author	Ting Jin Hugo Lavoie Malha Sahmi Maud David Christine Hilt Amy Hammell Marc Therrien
author_facet	Ting Jin Hugo Lavoie Malha Sahmi Maud David Christine Hilt Amy Hammell Marc Therrien
author_sort	Ting Jin
title	RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
title_short	RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
title_full	RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
title_fullStr	RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
title_full_unstemmed	RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
title_sort	raf inhibitors promote ras-raf interaction by allosterically disrupting raf autoinhibition
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/72b7a7f1b9c84f32af4cc1decc0c0c7c
work_keys_str_mv	AT tingjin rafinhibitorspromoterasrafinteractionbyallostericallydisruptingrafautoinhibition AT hugolavoie rafinhibitorspromoterasrafinteractionbyallostericallydisruptingrafautoinhibition AT malhasahmi rafinhibitorspromoterasrafinteractionbyallostericallydisruptingrafautoinhibition AT mauddavid rafinhibitorspromoterasrafinteractionbyallostericallydisruptingrafautoinhibition AT christinehilt rafinhibitorspromoterasrafinteractionbyallostericallydisruptingrafautoinhibition AT amyhammell rafinhibitorspromoterasrafinteractionbyallostericallydisruptingrafautoinhibition AT marctherrien rafinhibitorspromoterasrafinteractionbyallostericallydisruptingrafautoinhibition
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RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition

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