Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4R gene in postmenopausal women

Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4R gene in postmenopausal women

Jacek Brodowski,1 Małgorzata Szkup,2 Anna Jurczak,2 Sylwia Wieder-Huszla,2 Agnieszka Brodowska,3 Maria Laszczyńska,4 Beata Karakiewicz,5 Katarzyna Kęcka,1 Elżbieta Grochans2 1Primary Care Department, Pomeranian Medical University in Szczecin, 2Department of Nursing, Pomeranian Medical University in...

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Autores principales: Brodowski J, Szkup M, Jurczak A, Wieder-Huszla S, Brodowska A, Laszczyńska M, Karakiewicz B, Kęcka K, Grochans E
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
melanocortin type 4 receptor (MC4R)
postmenopausal women
metabolic syndrome
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/72c0d392442b4f78a832e0be822d1637
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spelling oai:doaj.org-article:72c0d392442b4f78a832e0be822d16372021-12-02T02:21:48ZSearching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4R gene in postmenopausal women1178-1998https://doaj.org/article/72c0d392442b4f78a832e0be822d16372017-03-01T00:00:00Zhttps://www.dovepress.com/searching-for-the-relationship-between-the-parameters-of-metabolic-syn-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jacek Brodowski,1 Małgorzata Szkup,2 Anna Jurczak,2 Sylwia Wieder-Huszla,2 Agnieszka Brodowska,3 Maria Laszczyńska,4 Beata Karakiewicz,5 Katarzyna Kęcka,1 Elżbieta Grochans2 1Primary Care Department, Pomeranian Medical University in Szczecin, 2Department of Nursing, Pomeranian Medical University in Szczecin, 3Clinic of Gynecology, Endocrinology, and Gynecologic Oncology, Pomeranian Medical University in Szczecin, 4Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 5Public Health Department, Pomeranian Medical University in Szczecin, Żołnierska, Szczecin, Poland Abstract: Metabolic syndrome (MS) is widespread in the human population, and its incidence is continuously increasing, generating serious health problems. The purpose of this study was to find the relationship between the parameters of MS and the melanocortin type 4 receptor (MC4R) gene polymorphism in postmenopausal women. The study involved 344 healthy Polish women, who had their last menstrual cycle 1 year ago or earlier. The study included blood analysis, survey, and body measurements. The mean age was 58.5±6.6 years. An increased body mass index was observed in 65.7% and abdominal obesity in 80.3% of the study population. MS was diagnosed in 40.7% of all participants, including 39.3% of women with the T/T genotype and 44.7% of those with the C/X genotype (χ2 test; P>0.05). A logistic regression model showed that the probability of MS was higher in patients with the C/X genotype (odds ratio =1.25) (χ2 test; P>0.05). The study concluded that MS is a very common condition among postmenopausal women. The C/X genotype of the MC4R gene seems to predispose postmenopausal women to developing some MS symptoms. Keywords: melanocortin type 4 receptor (MC4R), postmenopausal women, metabolic syndromeBrodowski JSzkup MJurczak AWieder-Huszla SBrodowska ALaszczyńska MKarakiewicz BKęcka KGrochans EDove Medical Pressarticlemelanocortin type 4 receptor (MC4R)postmenopausal womenmetabolic syndromeGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 549-555 (2017)
institution DOAJ
collection DOAJ
language EN
topic melanocortin type 4 receptor (MC4R)
postmenopausal women
metabolic syndrome
Geriatrics
RC952-954.6
spellingShingle melanocortin type 4 receptor (MC4R)
postmenopausal women
metabolic syndrome
Geriatrics
RC952-954.6
Brodowski J
Szkup M
Jurczak A
Wieder-Huszla S
Brodowska A
Laszczyńska M
Karakiewicz B
Kęcka K
Grochans E
Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4R gene in postmenopausal women
description Jacek Brodowski,1 Małgorzata Szkup,2 Anna Jurczak,2 Sylwia Wieder-Huszla,2 Agnieszka Brodowska,3 Maria Laszczyńska,4 Beata Karakiewicz,5 Katarzyna Kęcka,1 Elżbieta Grochans2 1Primary Care Department, Pomeranian Medical University in Szczecin, 2Department of Nursing, Pomeranian Medical University in Szczecin, 3Clinic of Gynecology, Endocrinology, and Gynecologic Oncology, Pomeranian Medical University in Szczecin, 4Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 5Public Health Department, Pomeranian Medical University in Szczecin, Żołnierska, Szczecin, Poland Abstract: Metabolic syndrome (MS) is widespread in the human population, and its incidence is continuously increasing, generating serious health problems. The purpose of this study was to find the relationship between the parameters of MS and the melanocortin type 4 receptor (MC4R) gene polymorphism in postmenopausal women. The study involved 344 healthy Polish women, who had their last menstrual cycle 1 year ago or earlier. The study included blood analysis, survey, and body measurements. The mean age was 58.5±6.6 years. An increased body mass index was observed in 65.7% and abdominal obesity in 80.3% of the study population. MS was diagnosed in 40.7% of all participants, including 39.3% of women with the T/T genotype and 44.7% of those with the C/X genotype (χ2 test; P>0.05). A logistic regression model showed that the probability of MS was higher in patients with the C/X genotype (odds ratio =1.25) (χ2 test; P>0.05). The study concluded that MS is a very common condition among postmenopausal women. The C/X genotype of the MC4R gene seems to predispose postmenopausal women to developing some MS symptoms. Keywords: melanocortin type 4 receptor (MC4R), postmenopausal women, metabolic syndrome
format article
author Brodowski J
Szkup M
Jurczak A
Wieder-Huszla S
Brodowska A
Laszczyńska M
Karakiewicz B
Kęcka K
Grochans E
author_facet Brodowski J
Szkup M
Jurczak A
Wieder-Huszla S
Brodowska A
Laszczyńska M
Karakiewicz B
Kęcka K
Grochans E
author_sort Brodowski J
title Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4R gene in postmenopausal women
title_short Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4R gene in postmenopausal women
title_full Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4R gene in postmenopausal women
title_fullStr Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4R gene in postmenopausal women
title_full_unstemmed Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4R gene in postmenopausal women
title_sort searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (t>c) polymorphism of the mc4r gene in postmenopausal women
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/72c0d392442b4f78a832e0be822d1637
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