Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain

In order to validate a previously inferred function of the lateral prefrontal cortex (LPFC)-caudate nucleus (CdN) pathway in humans in inhibitory control and working memory, Oguchi et al used pathway-selective chemogenetic manipulation of neural activity in macaques. By suppressing pathway-specific...

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Autores principales:	Mineki Oguchi, Shingo Tanaka, Xiaochuan Pan, Takefumi Kikusui, Keiko Moriya-Ito, Shigeki Kato, Kazuto Kobayashi, Masamichi Sakagami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/72c2b3b4a39f48079b44015afc54d842
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spelling	oai:doaj.org-article:72c2b3b4a39f48079b44015afc54d8422021-12-02T15:16:05ZChemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain10.1038/s42003-021-02623-y2399-3642https://doaj.org/article/72c2b3b4a39f48079b44015afc54d8422021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02623-yhttps://doaj.org/toc/2399-3642In order to validate a previously inferred function of the lateral prefrontal cortex (LPFC)-caudate nucleus (CdN) pathway in humans in inhibitory control and working memory, Oguchi et al used pathway-selective chemogenetic manipulation of neural activity in macaques. By suppressing pathway-specific neural activity and observing resultant behavioural changes, they provided evidence that the LPFC-CdN pathway does indeed play a role in inhibitory control.Mineki OguchiShingo TanakaXiaochuan PanTakefumi KikusuiKeiko Moriya-ItoShigeki KatoKazuto KobayashiMasamichi SakagamiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mineki Oguchi Shingo Tanaka Xiaochuan Pan Takefumi Kikusui Keiko Moriya-Ito Shigeki Kato Kazuto Kobayashi Masamichi Sakagami Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain
description	In order to validate a previously inferred function of the lateral prefrontal cortex (LPFC)-caudate nucleus (CdN) pathway in humans in inhibitory control and working memory, Oguchi et al used pathway-selective chemogenetic manipulation of neural activity in macaques. By suppressing pathway-specific neural activity and observing resultant behavioural changes, they provided evidence that the LPFC-CdN pathway does indeed play a role in inhibitory control.
format	article
author	Mineki Oguchi Shingo Tanaka Xiaochuan Pan Takefumi Kikusui Keiko Moriya-Ito Shigeki Kato Kazuto Kobayashi Masamichi Sakagami
author_facet	Mineki Oguchi Shingo Tanaka Xiaochuan Pan Takefumi Kikusui Keiko Moriya-Ito Shigeki Kato Kazuto Kobayashi Masamichi Sakagami
author_sort	Mineki Oguchi
title	Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain
title_short	Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain
title_full	Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain
title_fullStr	Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain
title_full_unstemmed	Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain
title_sort	chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/72c2b3b4a39f48079b44015afc54d842
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Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain

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