Evidence of a hormonal reshuffle in the cecal metabolome fingerprint of a strain of rats resistant to decompression sickness

Abstract On one side, decompression sickness (DCS) with neurological disorders lead to a reshuffle of the fecal metabolome from rat caecum. On the other side, there is high inter-individual variability in terms of occurrence of DCS. One could wonder whether the fecal metabolome could be linked to th...

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Autores principales:	Nicolas Vallee, Emmanuel Dugrenot, Anne-Virginie Desruelle, Catherine Tardivel, Jean-Charles Martin, Anthony Guernec, Alain Boussuges, Sarah Rives, Jean-Jacques Risso, François Guerrero
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72c2e6b9eb3248849a920f5f2070bcb5
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spelling	oai:doaj.org-article:72c2e6b9eb3248849a920f5f2070bcb52021-12-02T18:02:47ZEvidence of a hormonal reshuffle in the cecal metabolome fingerprint of a strain of rats resistant to decompression sickness10.1038/s41598-021-87952-y2045-2322https://doaj.org/article/72c2e6b9eb3248849a920f5f2070bcb52021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87952-yhttps://doaj.org/toc/2045-2322Abstract On one side, decompression sickness (DCS) with neurological disorders lead to a reshuffle of the fecal metabolome from rat caecum. On the other side, there is high inter-individual variability in terms of occurrence of DCS. One could wonder whether the fecal metabolome could be linked to the DCS-susceptibility. We decided to study male and female rats selected for their resistance to decompression sickness, and we hypothesize a strong impregnation concerning the fecal metabolome. The aim is to verify whether the rats resistant to the accident have a fecal metabolomic signature different from the stem generations sensitive to DCS. 39 DCS-resistant animals (21 females and 18 males), aged 14 weeks, were compared to 18 age-matched standard Wistar rats (10 females and 8 males), i.e., the same as those we used for the founding stock. Conventional and ChemRICH approaches helped the metabolomic interpretation of the 226 chemical compounds analyzed in the cecal content. Statistical analysis shows a panel of 81 compounds whose expression had changed following the selection of rats based on their resistance to DCS. 63 compounds are sex related. 39 are in common. This study shows the spectral fingerprint of the fecal metabolome from the caecum of a strain of rats resistant to decompression sickness. This study also confirms a difference linked to sex in the metabolome of non-selected rats, which disappear with selective breeding. Results suggest hormonal and energetic reshuffle, including steroids sugars or antibiotic compounds, whether in the host or in the microbial community.Nicolas ValleeEmmanuel DugrenotAnne-Virginie DesruelleCatherine TardivelJean-Charles MartinAnthony GuernecAlain BoussugesSarah RivesJean-Jacques RissoFrançois GuerreroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicolas Vallee Emmanuel Dugrenot Anne-Virginie Desruelle Catherine Tardivel Jean-Charles Martin Anthony Guernec Alain Boussuges Sarah Rives Jean-Jacques Risso François Guerrero Evidence of a hormonal reshuffle in the cecal metabolome fingerprint of a strain of rats resistant to decompression sickness
description	Abstract On one side, decompression sickness (DCS) with neurological disorders lead to a reshuffle of the fecal metabolome from rat caecum. On the other side, there is high inter-individual variability in terms of occurrence of DCS. One could wonder whether the fecal metabolome could be linked to the DCS-susceptibility. We decided to study male and female rats selected for their resistance to decompression sickness, and we hypothesize a strong impregnation concerning the fecal metabolome. The aim is to verify whether the rats resistant to the accident have a fecal metabolomic signature different from the stem generations sensitive to DCS. 39 DCS-resistant animals (21 females and 18 males), aged 14 weeks, were compared to 18 age-matched standard Wistar rats (10 females and 8 males), i.e., the same as those we used for the founding stock. Conventional and ChemRICH approaches helped the metabolomic interpretation of the 226 chemical compounds analyzed in the cecal content. Statistical analysis shows a panel of 81 compounds whose expression had changed following the selection of rats based on their resistance to DCS. 63 compounds are sex related. 39 are in common. This study shows the spectral fingerprint of the fecal metabolome from the caecum of a strain of rats resistant to decompression sickness. This study also confirms a difference linked to sex in the metabolome of non-selected rats, which disappear with selective breeding. Results suggest hormonal and energetic reshuffle, including steroids sugars or antibiotic compounds, whether in the host or in the microbial community.
format	article
author	Nicolas Vallee Emmanuel Dugrenot Anne-Virginie Desruelle Catherine Tardivel Jean-Charles Martin Anthony Guernec Alain Boussuges Sarah Rives Jean-Jacques Risso François Guerrero
author_facet	Nicolas Vallee Emmanuel Dugrenot Anne-Virginie Desruelle Catherine Tardivel Jean-Charles Martin Anthony Guernec Alain Boussuges Sarah Rives Jean-Jacques Risso François Guerrero
author_sort	Nicolas Vallee
title	Evidence of a hormonal reshuffle in the cecal metabolome fingerprint of a strain of rats resistant to decompression sickness
title_short	Evidence of a hormonal reshuffle in the cecal metabolome fingerprint of a strain of rats resistant to decompression sickness
title_full	Evidence of a hormonal reshuffle in the cecal metabolome fingerprint of a strain of rats resistant to decompression sickness
title_fullStr	Evidence of a hormonal reshuffle in the cecal metabolome fingerprint of a strain of rats resistant to decompression sickness
title_full_unstemmed	Evidence of a hormonal reshuffle in the cecal metabolome fingerprint of a strain of rats resistant to decompression sickness
title_sort	evidence of a hormonal reshuffle in the cecal metabolome fingerprint of a strain of rats resistant to decompression sickness
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/72c2e6b9eb3248849a920f5f2070bcb5
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Evidence of a hormonal reshuffle in the cecal metabolome fingerprint of a strain of rats resistant to decompression sickness

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