Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections

Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections

Host immune responses exert selective pressure on Plasmodium falciparum. Here, the authors show that allele-specific immunity impacts the antigenic diversity of individual malaria infections. This process partially explains the extreme amino acid diversity of many parasite antigens and suggests that...

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Autores principales: Angela M. Early, Marc Lievens, Bronwyn L. MacInnis, Christian F. Ockenhouse, Sarah K. Volkman, Samuel Adjei, Tsiri Agbenyega, Daniel Ansong, Stacey Gondi, Brian Greenwood, Mary Hamel, Chris Odero, Kephas Otieno, Walter Otieno, Seth Owusu-Agyei, Kwaku Poku Asante, Hermann Sorgho, Lucas Tina, Halidou Tinto, Innocent Valea, Dyann F. Wirth, Daniel E. Neafsey
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/72c34aa44dde4a05811cc3f406231978
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Sumario:Host immune responses exert selective pressure on Plasmodium falciparum. Here, the authors show that allele-specific immunity impacts the antigenic diversity of individual malaria infections. This process partially explains the extreme amino acid diversity of many parasite antigens and suggests that vaccines should account for allele-specific immunity.

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