Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections

Host immune responses exert selective pressure on Plasmodium falciparum. Here, the authors show that allele-specific immunity impacts the antigenic diversity of individual malaria infections. This process partially explains the extreme amino acid diversity of many parasite antigens and suggests that...

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Autores principales:	Angela M. Early, Marc Lievens, Bronwyn L. MacInnis, Christian F. Ockenhouse, Sarah K. Volkman, Samuel Adjei, Tsiri Agbenyega, Daniel Ansong, Stacey Gondi, Brian Greenwood, Mary Hamel, Chris Odero, Kephas Otieno, Walter Otieno, Seth Owusu-Agyei, Kwaku Poku Asante, Hermann Sorgho, Lucas Tina, Halidou Tinto, Innocent Valea, Dyann F. Wirth, Daniel E. Neafsey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/72c34aa44dde4a05811cc3f406231978
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spelling	oai:doaj.org-article:72c34aa44dde4a05811cc3f4062319782021-12-02T14:39:46ZHost-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections10.1038/s41467-018-03807-72041-1723https://doaj.org/article/72c34aa44dde4a05811cc3f4062319782018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03807-7https://doaj.org/toc/2041-1723Host immune responses exert selective pressure on Plasmodium falciparum. Here, the authors show that allele-specific immunity impacts the antigenic diversity of individual malaria infections. This process partially explains the extreme amino acid diversity of many parasite antigens and suggests that vaccines should account for allele-specific immunity.Angela M. EarlyMarc LievensBronwyn L. MacInnisChristian F. OckenhouseSarah K. VolkmanSamuel AdjeiTsiri AgbenyegaDaniel AnsongStacey GondiBrian GreenwoodMary HamelChris OderoKephas OtienoWalter OtienoSeth Owusu-AgyeiKwaku Poku AsanteHermann SorghoLucas TinaHalidou TintoInnocent ValeaDyann F. WirthDaniel E. NeafseyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Angela M. Early Marc Lievens Bronwyn L. MacInnis Christian F. Ockenhouse Sarah K. Volkman Samuel Adjei Tsiri Agbenyega Daniel Ansong Stacey Gondi Brian Greenwood Mary Hamel Chris Odero Kephas Otieno Walter Otieno Seth Owusu-Agyei Kwaku Poku Asante Hermann Sorgho Lucas Tina Halidou Tinto Innocent Valea Dyann F. Wirth Daniel E. Neafsey Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections
description	Host immune responses exert selective pressure on Plasmodium falciparum. Here, the authors show that allele-specific immunity impacts the antigenic diversity of individual malaria infections. This process partially explains the extreme amino acid diversity of many parasite antigens and suggests that vaccines should account for allele-specific immunity.
format	article
author	Angela M. Early Marc Lievens Bronwyn L. MacInnis Christian F. Ockenhouse Sarah K. Volkman Samuel Adjei Tsiri Agbenyega Daniel Ansong Stacey Gondi Brian Greenwood Mary Hamel Chris Odero Kephas Otieno Walter Otieno Seth Owusu-Agyei Kwaku Poku Asante Hermann Sorgho Lucas Tina Halidou Tinto Innocent Valea Dyann F. Wirth Daniel E. Neafsey
author_facet	Angela M. Early Marc Lievens Bronwyn L. MacInnis Christian F. Ockenhouse Sarah K. Volkman Samuel Adjei Tsiri Agbenyega Daniel Ansong Stacey Gondi Brian Greenwood Mary Hamel Chris Odero Kephas Otieno Walter Otieno Seth Owusu-Agyei Kwaku Poku Asante Hermann Sorgho Lucas Tina Halidou Tinto Innocent Valea Dyann F. Wirth Daniel E. Neafsey
author_sort	Angela M. Early
title	Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections
title_short	Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections
title_full	Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections
title_fullStr	Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections
title_full_unstemmed	Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections
title_sort	host-mediated selection impacts the diversity of plasmodium falciparum antigens within infections
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/72c34aa44dde4a05811cc3f406231978
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Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections

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