Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis

Abstract Primary Toxoplasma gondii infection in pregnant women may result in abortion, stillbirth, or lifelong disabilities of the unborn child. One of the main transmission routes to humans is consumption of raw or undercooked meat containing T. gondii tissue cysts. We aim to determine and compare...

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Autores principales:	Huifang Deng, Brecht Devleesschauwer, Mingyuan Liu, Jianhua Li, Yongning Wu, Joke W. B. van der Giessen, Marieke Opsteegh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72c5a823cad1440194c2ab344ea21d32
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spelling	oai:doaj.org-article:72c5a823cad1440194c2ab344ea21d322021-12-02T15:05:02ZSeroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis10.1038/s41598-018-24361-82045-2322https://doaj.org/article/72c5a823cad1440194c2ab344ea21d322018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24361-8https://doaj.org/toc/2045-2322Abstract Primary Toxoplasma gondii infection in pregnant women may result in abortion, stillbirth, or lifelong disabilities of the unborn child. One of the main transmission routes to humans is consumption of raw or undercooked meat containing T. gondii tissue cysts. We aim to determine and compare the regional distribution of T. gondii seroprevalence in pregnant women and meat-producing livestock in China through a systematic literature review. A total of 272 eligible publications were identified from Medline, Scopus, Embase and China National Knowledge Infrastructure. Apparent and true seroprevalence were analysed by region using a novel Bayesian hierarchical model that allowed incorporating sensitivity and specificity of the applied serological assays. The true seroprevalence of T. gondii in pregnant women was 5.0% or less in seven regions of China. The median of the regional true seroprevalences in pigs (24%) was significantly higher than in cattle (9.5%), but it was not significantly higher than in chickens (20%) and small ruminants (20%). This study represents the first use of a Bayesian hierarchical model to obtain regional true seroprevalence. These results, in combination with meat consumption data, can be used to better understand the contribution of meat-producing animals to human T. gondii infection in China.Huifang DengBrecht DevleesschauwerMingyuan LiuJianhua LiYongning WuJoke W. B. van der GiessenMarieke OpsteeghNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huifang Deng Brecht Devleesschauwer Mingyuan Liu Jianhua Li Yongning Wu Joke W. B. van der Giessen Marieke Opsteegh Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis
description	Abstract Primary Toxoplasma gondii infection in pregnant women may result in abortion, stillbirth, or lifelong disabilities of the unborn child. One of the main transmission routes to humans is consumption of raw or undercooked meat containing T. gondii tissue cysts. We aim to determine and compare the regional distribution of T. gondii seroprevalence in pregnant women and meat-producing livestock in China through a systematic literature review. A total of 272 eligible publications were identified from Medline, Scopus, Embase and China National Knowledge Infrastructure. Apparent and true seroprevalence were analysed by region using a novel Bayesian hierarchical model that allowed incorporating sensitivity and specificity of the applied serological assays. The true seroprevalence of T. gondii in pregnant women was 5.0% or less in seven regions of China. The median of the regional true seroprevalences in pigs (24%) was significantly higher than in cattle (9.5%), but it was not significantly higher than in chickens (20%) and small ruminants (20%). This study represents the first use of a Bayesian hierarchical model to obtain regional true seroprevalence. These results, in combination with meat consumption data, can be used to better understand the contribution of meat-producing animals to human T. gondii infection in China.
format	article
author	Huifang Deng Brecht Devleesschauwer Mingyuan Liu Jianhua Li Yongning Wu Joke W. B. van der Giessen Marieke Opsteegh
author_facet	Huifang Deng Brecht Devleesschauwer Mingyuan Liu Jianhua Li Yongning Wu Joke W. B. van der Giessen Marieke Opsteegh
author_sort	Huifang Deng
title	Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis
title_short	Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis
title_full	Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis
title_fullStr	Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis
title_full_unstemmed	Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis
title_sort	seroprevalence of toxoplasma gondii in pregnant women and livestock in the mainland of china: a systematic review and hierarchical meta-analysis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/72c5a823cad1440194c2ab344ea21d32
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Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis

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