The structure of a dimeric form of SARS-CoV-2 polymerase

The structure of a dimeric form of SARS-CoV-2 polymerase

Jochheim et al report an alternative, dimeric form of the coronavirus SARS-CoV-2 RNA dependent RNA polymerase (RdRp), which is used to replicate and transcribe its genome. They resolve its structure at 5.5 Å resolution and speculate that the dimer facilitates template switching during production of...

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Autores principales: Florian A. Jochheim, Dimitry Tegunov, Hauke S. Hillen, Jana Schmitzová, Goran Kokic, Christian Dienemann, Patrick Cramer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/72c6389f55874b8695d625c32dbc3d02
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spelling oai:doaj.org-article:72c6389f55874b8695d625c32dbc3d022021-12-02T18:53:08ZThe structure of a dimeric form of SARS-CoV-2 polymerase10.1038/s42003-021-02529-92399-3642https://doaj.org/article/72c6389f55874b8695d625c32dbc3d022021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02529-9https://doaj.org/toc/2399-3642Jochheim et al report an alternative, dimeric form of the coronavirus SARS-CoV-2 RNA dependent RNA polymerase (RdRp), which is used to replicate and transcribe its genome. They resolve its structure at 5.5 Å resolution and speculate that the dimer facilitates template switching during production of sub-genomic RNAs.Florian A. JochheimDimitry TegunovHauke S. HillenJana SchmitzováGoran KokicChristian DienemannPatrick CramerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-5 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Florian A. Jochheim
Dimitry Tegunov
Hauke S. Hillen
Jana Schmitzová
Goran Kokic
Christian Dienemann
Patrick Cramer
The structure of a dimeric form of SARS-CoV-2 polymerase
description Jochheim et al report an alternative, dimeric form of the coronavirus SARS-CoV-2 RNA dependent RNA polymerase (RdRp), which is used to replicate and transcribe its genome. They resolve its structure at 5.5 Å resolution and speculate that the dimer facilitates template switching during production of sub-genomic RNAs.
format article
author Florian A. Jochheim
Dimitry Tegunov
Hauke S. Hillen
Jana Schmitzová
Goran Kokic
Christian Dienemann
Patrick Cramer
author_facet Florian A. Jochheim
Dimitry Tegunov
Hauke S. Hillen
Jana Schmitzová
Goran Kokic
Christian Dienemann
Patrick Cramer
author_sort Florian A. Jochheim
title The structure of a dimeric form of SARS-CoV-2 polymerase
title_short The structure of a dimeric form of SARS-CoV-2 polymerase
title_full The structure of a dimeric form of SARS-CoV-2 polymerase
title_fullStr The structure of a dimeric form of SARS-CoV-2 polymerase
title_full_unstemmed The structure of a dimeric form of SARS-CoV-2 polymerase
title_sort structure of a dimeric form of sars-cov-2 polymerase
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/72c6389f55874b8695d625c32dbc3d02
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