Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes

Enantioselective oxidative cross-coupling of unactivated C(sp 3)−H bonds and terminal alkynes is challenging. Here, the authors developed a copper/cinchona alkaloid catalyst for the asymmetric Sonogashira-type alkynylation of C(sp 3)-H bonds via radical intermediates.

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Autores principales:	Zhen-Hua Zhang, Xiao-Yang Dong, Xuan-Yi Du, Qiang-Shuai Gu, Zhong-Liang Li, Xin-Yuan Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/72c8a97b2c514ca89ef9c53d31c4401e
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spelling	oai:doaj.org-article:72c8a97b2c514ca89ef9c53d31c4401e2021-12-02T16:57:46ZCopper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes10.1038/s41467-019-13705-12041-1723https://doaj.org/article/72c8a97b2c514ca89ef9c53d31c4401e2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13705-1https://doaj.org/toc/2041-1723Enantioselective oxidative cross-coupling of unactivated C(sp 3)−H bonds and terminal alkynes is challenging. Here, the authors developed a copper/cinchona alkaloid catalyst for the asymmetric Sonogashira-type alkynylation of C(sp 3)-H bonds via radical intermediates.Zhen-Hua ZhangXiao-Yang DongXuan-Yi DuQiang-Shuai GuZhong-Liang LiXin-Yuan LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhen-Hua Zhang Xiao-Yang Dong Xuan-Yi Du Qiang-Shuai Gu Zhong-Liang Li Xin-Yuan Liu Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes
description	Enantioselective oxidative cross-coupling of unactivated C(sp 3)−H bonds and terminal alkynes is challenging. Here, the authors developed a copper/cinchona alkaloid catalyst for the asymmetric Sonogashira-type alkynylation of C(sp 3)-H bonds via radical intermediates.
format	article
author	Zhen-Hua Zhang Xiao-Yang Dong Xuan-Yi Du Qiang-Shuai Gu Zhong-Liang Li Xin-Yuan Liu
author_facet	Zhen-Hua Zhang Xiao-Yang Dong Xuan-Yi Du Qiang-Shuai Gu Zhong-Liang Li Xin-Yuan Liu
author_sort	Zhen-Hua Zhang
title	Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes
title_short	Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes
title_full	Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes
title_fullStr	Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes
title_full_unstemmed	Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes
title_sort	copper-catalyzed enantioselective sonogashira-type oxidative cross-coupling of unactivated c(sp 3)−h bonds with alkynes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/72c8a97b2c514ca89ef9c53d31c4401e
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Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes

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