Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes

Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes

Enantioselective oxidative cross-coupling of unactivated C(sp 3)−H bonds and terminal alkynes is challenging. Here, the authors developed a copper/cinchona alkaloid catalyst for the asymmetric Sonogashira-type alkynylation of C(sp 3)-H bonds via radical intermediates.

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Autores principales: Zhen-Hua Zhang, Xiao-Yang Dong, Xuan-Yi Du, Qiang-Shuai Gu, Zhong-Liang Li, Xin-Yuan Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/72c8a97b2c514ca89ef9c53d31c4401e
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