Ring-opening functionalizations of unstrained cyclic amines enabled by difluorocarbene transfer

Cyclic amines are commonly present in natural products and synthetic compounds, but methods for their skeletal diversification are limited. Here, the authors report a strategy for selective ring-opening functionalization of unstrained cyclic amines to pluripotent products that can be further diversi...

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Bibliographic Details
Main Authors: Youyoung Kim, Joon Heo, Dongwook Kim, Sukbok Chang, Sangwon Seo
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/72ca16811b72489c85e34dc25604f0f7
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Summary:Cyclic amines are commonly present in natural products and synthetic compounds, but methods for their skeletal diversification are limited. Here, the authors report a strategy for selective ring-opening functionalization of unstrained cyclic amines to pluripotent products that can be further diversified.