Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease

Finding therapeutic strategies for aggressive triple negative breast cancer (TNBC) is an important challenge in clinical practice. Here, the authors identify a multi-kinases inhibitor with antitumor activity and able overcome chemotherapy resistance of TNBC in vivo.

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Autores principales:	Katsutoshi Sato, Amol A. Padgaonkar, Stacey J. Baker, Stephen C. Cosenza, Olga Rechkoblit, D. R. C. Venkata Subbaiah, Josep Domingo-Domenech, Alison Bartkowski, Elisa R. Port, Aneel K. Aggarwal, M. V. Ramana Reddy, Hanna Y. Irie, E. Premkumar Reddy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/72cb347eb0744a6cbe886fef6ee09227
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spelling	oai:doaj.org-article:72cb347eb0744a6cbe886fef6ee092272021-12-02T18:49:35ZSimultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease10.1038/s41467-021-24878-z2041-1723https://doaj.org/article/72cb347eb0744a6cbe886fef6ee092272021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24878-zhttps://doaj.org/toc/2041-1723Finding therapeutic strategies for aggressive triple negative breast cancer (TNBC) is an important challenge in clinical practice. Here, the authors identify a multi-kinases inhibitor with antitumor activity and able overcome chemotherapy resistance of TNBC in vivo.Katsutoshi SatoAmol A. PadgaonkarStacey J. BakerStephen C. CosenzaOlga RechkoblitD. R. C. Venkata SubbaiahJosep Domingo-DomenechAlison BartkowskiElisa R. PortAneel K. AggarwalM. V. Ramana ReddyHanna Y. IrieE. Premkumar ReddyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katsutoshi Sato Amol A. Padgaonkar Stacey J. Baker Stephen C. Cosenza Olga Rechkoblit D. R. C. Venkata Subbaiah Josep Domingo-Domenech Alison Bartkowski Elisa R. Port Aneel K. Aggarwal M. V. Ramana Reddy Hanna Y. Irie E. Premkumar Reddy Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease
description	Finding therapeutic strategies for aggressive triple negative breast cancer (TNBC) is an important challenge in clinical practice. Here, the authors identify a multi-kinases inhibitor with antitumor activity and able overcome chemotherapy resistance of TNBC in vivo.
format	article
author	Katsutoshi Sato Amol A. Padgaonkar Stacey J. Baker Stephen C. Cosenza Olga Rechkoblit D. R. C. Venkata Subbaiah Josep Domingo-Domenech Alison Bartkowski Elisa R. Port Aneel K. Aggarwal M. V. Ramana Reddy Hanna Y. Irie E. Premkumar Reddy
author_facet	Katsutoshi Sato Amol A. Padgaonkar Stacey J. Baker Stephen C. Cosenza Olga Rechkoblit D. R. C. Venkata Subbaiah Josep Domingo-Domenech Alison Bartkowski Elisa R. Port Aneel K. Aggarwal M. V. Ramana Reddy Hanna Y. Irie E. Premkumar Reddy
author_sort	Katsutoshi Sato
title	Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease
title_short	Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease
title_full	Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease
title_fullStr	Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease
title_full_unstemmed	Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease
title_sort	simultaneous ck2/tnik/dyrk1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/72cb347eb0744a6cbe886fef6ee09227
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Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease

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