Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project

Abstract The objective of this study was to identify distinct clusters of individuals that exhibit unique patterns of modifiable lifestyle-related behaviours and to determine how these patterns are associated with the risk of developing colorectal cancer (CRC). The study consisted of 26,460 particip...

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Autores principales:	Dylan E. O’Sullivan, Amy Metcalfe, Troy W. R. Hillier, Will D. King, Sangmin Lee, Joy Pader, Darren R. Brenner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72cbde3ff3a1489eaee128c0685ade29
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spelling	oai:doaj.org-article:72cbde3ff3a1489eaee128c0685ade292021-12-02T16:09:09ZCombinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project10.1038/s41598-020-76294-w2045-2322https://doaj.org/article/72cbde3ff3a1489eaee128c0685ade292020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-76294-whttps://doaj.org/toc/2045-2322Abstract The objective of this study was to identify distinct clusters of individuals that exhibit unique patterns of modifiable lifestyle-related behaviours and to determine how these patterns are associated with the risk of developing colorectal cancer (CRC). The study consisted of 26,460 participants and 267 CRC cases from Alberta’s Tomorrow Project. Exploratory latent class analysis of risk behaviours (obesity, physical inactivity, meat consumption, smoking, alcohol consumption, and fruit and vegetable consumption) and Cox proportional hazard models were utilized. Seven unique behavioural groups were identified, where the risk of CRC was 2.34 to 2.87 times greater for high risk groups compared to the low risk group. Sex-specific models identified higher risk groups among men (Hazard Ratios [HRs]: 3.15 to 3.89) than among women (HRs: 1.99 to 2.19). Targeting groups defined by clustering of behaviours could potentially lead to more effective prevention of CRC on a population level.Dylan E. O’SullivanAmy MetcalfeTroy W. R. HillierWill D. KingSangmin LeeJoy PaderDarren R. BrennerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dylan E. O’Sullivan Amy Metcalfe Troy W. R. Hillier Will D. King Sangmin Lee Joy Pader Darren R. Brenner Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
description	Abstract The objective of this study was to identify distinct clusters of individuals that exhibit unique patterns of modifiable lifestyle-related behaviours and to determine how these patterns are associated with the risk of developing colorectal cancer (CRC). The study consisted of 26,460 participants and 267 CRC cases from Alberta’s Tomorrow Project. Exploratory latent class analysis of risk behaviours (obesity, physical inactivity, meat consumption, smoking, alcohol consumption, and fruit and vegetable consumption) and Cox proportional hazard models were utilized. Seven unique behavioural groups were identified, where the risk of CRC was 2.34 to 2.87 times greater for high risk groups compared to the low risk group. Sex-specific models identified higher risk groups among men (Hazard Ratios [HRs]: 3.15 to 3.89) than among women (HRs: 1.99 to 2.19). Targeting groups defined by clustering of behaviours could potentially lead to more effective prevention of CRC on a population level.
format	article
author	Dylan E. O’Sullivan Amy Metcalfe Troy W. R. Hillier Will D. King Sangmin Lee Joy Pader Darren R. Brenner
author_facet	Dylan E. O’Sullivan Amy Metcalfe Troy W. R. Hillier Will D. King Sangmin Lee Joy Pader Darren R. Brenner
author_sort	Dylan E. O’Sullivan
title	Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
title_short	Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
title_full	Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
title_fullStr	Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
title_full_unstemmed	Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
title_sort	combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in alberta’s tomorrow project
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/72cbde3ff3a1489eaee128c0685ade29
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Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project

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