miRNA Delivery by Nanosystems: State of the Art and Perspectives

MicroRNAs (miRNAs) are short (~21–23 nucleotides), non-coding endogenous RNA molecules that modulate gene expression at the post-transcriptional level via the endogenous RNA interference machinery of the cell. They have emerged as potential biopharmaceuticals candidates for the treatment of various...

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Autores principales:	Fernanda C. Moraes, Chantal Pichon, Didier Letourneur, Frédéric Chaubet
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	miRNA delivery non-viral vectors nanoparticles Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/72ce100320b243e6a7fc6d025709bf30
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spelling	oai:doaj.org-article:72ce100320b243e6a7fc6d025709bf302021-11-25T18:41:38ZmiRNA Delivery by Nanosystems: State of the Art and Perspectives10.3390/pharmaceutics131119011999-4923https://doaj.org/article/72ce100320b243e6a7fc6d025709bf302021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1901https://doaj.org/toc/1999-4923MicroRNAs (miRNAs) are short (~21–23 nucleotides), non-coding endogenous RNA molecules that modulate gene expression at the post-transcriptional level via the endogenous RNA interference machinery of the cell. They have emerged as potential biopharmaceuticals candidates for the treatment of various diseases, including cancer, cardiovascular and metabolic diseases. However, in order to advance miRNAs therapeutics into clinical settings, their delivery remains a major challenge. Different types of vectors have been investigated to allow the delivery of miRNA in the diseased tissue. In particular, non-viral delivery systems have shown important advantages such as versatility, low cost, easy fabrication and low immunogenicity. Here, we present a general overview of the main types of non-viral vectors developed for miRNA delivery, with their advantages, limitations and future perspectives.Fernanda C. MoraesChantal PichonDidier LetourneurFrédéric ChaubetMDPI AGarticlemiRNA deliverynon-viral vectorsnanoparticlesPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1901, p 1901 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	miRNA delivery non-viral vectors nanoparticles Pharmacy and materia medica RS1-441
spellingShingle	miRNA delivery non-viral vectors nanoparticles Pharmacy and materia medica RS1-441 Fernanda C. Moraes Chantal Pichon Didier Letourneur Frédéric Chaubet miRNA Delivery by Nanosystems: State of the Art and Perspectives
description	MicroRNAs (miRNAs) are short (~21–23 nucleotides), non-coding endogenous RNA molecules that modulate gene expression at the post-transcriptional level via the endogenous RNA interference machinery of the cell. They have emerged as potential biopharmaceuticals candidates for the treatment of various diseases, including cancer, cardiovascular and metabolic diseases. However, in order to advance miRNAs therapeutics into clinical settings, their delivery remains a major challenge. Different types of vectors have been investigated to allow the delivery of miRNA in the diseased tissue. In particular, non-viral delivery systems have shown important advantages such as versatility, low cost, easy fabrication and low immunogenicity. Here, we present a general overview of the main types of non-viral vectors developed for miRNA delivery, with their advantages, limitations and future perspectives.
format	article
author	Fernanda C. Moraes Chantal Pichon Didier Letourneur Frédéric Chaubet
author_facet	Fernanda C. Moraes Chantal Pichon Didier Letourneur Frédéric Chaubet
author_sort	Fernanda C. Moraes
title	miRNA Delivery by Nanosystems: State of the Art and Perspectives
title_short	miRNA Delivery by Nanosystems: State of the Art and Perspectives
title_full	miRNA Delivery by Nanosystems: State of the Art and Perspectives
title_fullStr	miRNA Delivery by Nanosystems: State of the Art and Perspectives
title_full_unstemmed	miRNA Delivery by Nanosystems: State of the Art and Perspectives
title_sort	mirna delivery by nanosystems: state of the art and perspectives
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/72ce100320b243e6a7fc6d025709bf30
work_keys_str_mv	AT fernandacmoraes mirnadeliverybynanosystemsstateoftheartandperspectives AT chantalpichon mirnadeliverybynanosystemsstateoftheartandperspectives AT didierletourneur mirnadeliverybynanosystemsstateoftheartandperspectives AT fredericchaubet mirnadeliverybynanosystemsstateoftheartandperspectives
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miRNA Delivery by Nanosystems: State of the Art and Perspectives

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