The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology
The prognosis of castration-resistant prostate cancers remains dismal, but accurate preclinical models can lead to effective therapies. Here the Melbourne Urological Research Alliance establish prostate cancer patient-derived xenografts, use the tumors for organoids and single-cell RNA-seq, and show...
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Nature Portfolio
2021
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oai:doaj.org-article:72ce33db9321419ba5cb98782c40a1e12021-12-02T18:01:16ZThe MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology10.1038/s41467-021-25175-52041-1723https://doaj.org/article/72ce33db9321419ba5cb98782c40a1e12021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25175-5https://doaj.org/toc/2041-1723The prognosis of castration-resistant prostate cancers remains dismal, but accurate preclinical models can lead to effective therapies. Here the Melbourne Urological Research Alliance establish prostate cancer patient-derived xenografts, use the tumors for organoids and single-cell RNA-seq, and show the efficacy of PARP inhibitor combination treatments.Gail P. RisbridgerAshlee K. ClarkLaura H. PorterRoxanne ToivanenAndrew BakshiNatalie L. ListerDavid PookCarmel J. PezaroShahneen SandhuShivakumar KeerthikumarRosalia Quezada UrbanMelissa PapargirisJenna KraskaHeather B. MadsenHong WangMichelle G. RichardsBirunthi NiranjanSamantha O’DeaLinda TengWilliam WheelahanZhuoer LiNicholas ChooJohn F. OuyangHeather ThorneLisa DevereuxRodney J. HicksShomik SenguptaLaurence HarewoodMahesh IddawalaArun A. AzadJeremy GoadJeremy GrummetJohn KourambasEdmond M. KwanDaniel MoonDeclan G. MurphyJohn PedersenDavid CloustonSam NordenAndrew RyanLuc FuricDavid L. GoodeMark FrydenbergMitchell G. LawrenceRenea A. TaylorNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
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DOAJ |
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EN |
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Science Q Gail P. Risbridger Ashlee K. Clark Laura H. Porter Roxanne Toivanen Andrew Bakshi Natalie L. Lister David Pook Carmel J. Pezaro Shahneen Sandhu Shivakumar Keerthikumar Rosalia Quezada Urban Melissa Papargiris Jenna Kraska Heather B. Madsen Hong Wang Michelle G. Richards Birunthi Niranjan Samantha O’Dea Linda Teng William Wheelahan Zhuoer Li Nicholas Choo John F. Ouyang Heather Thorne Lisa Devereux Rodney J. Hicks Shomik Sengupta Laurence Harewood Mahesh Iddawala Arun A. Azad Jeremy Goad Jeremy Grummet John Kourambas Edmond M. Kwan Daniel Moon Declan G. Murphy John Pedersen David Clouston Sam Norden Andrew Ryan Luc Furic David L. Goode Mark Frydenberg Mitchell G. Lawrence Renea A. Taylor The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| description |
The prognosis of castration-resistant prostate cancers remains dismal, but accurate preclinical models can lead to effective therapies. Here the Melbourne Urological Research Alliance establish prostate cancer patient-derived xenografts, use the tumors for organoids and single-cell RNA-seq, and show the efficacy of PARP inhibitor combination treatments. |
| format |
article |
| author |
Gail P. Risbridger Ashlee K. Clark Laura H. Porter Roxanne Toivanen Andrew Bakshi Natalie L. Lister David Pook Carmel J. Pezaro Shahneen Sandhu Shivakumar Keerthikumar Rosalia Quezada Urban Melissa Papargiris Jenna Kraska Heather B. Madsen Hong Wang Michelle G. Richards Birunthi Niranjan Samantha O’Dea Linda Teng William Wheelahan Zhuoer Li Nicholas Choo John F. Ouyang Heather Thorne Lisa Devereux Rodney J. Hicks Shomik Sengupta Laurence Harewood Mahesh Iddawala Arun A. Azad Jeremy Goad Jeremy Grummet John Kourambas Edmond M. Kwan Daniel Moon Declan G. Murphy John Pedersen David Clouston Sam Norden Andrew Ryan Luc Furic David L. Goode Mark Frydenberg Mitchell G. Lawrence Renea A. Taylor |
| author_facet |
Gail P. Risbridger Ashlee K. Clark Laura H. Porter Roxanne Toivanen Andrew Bakshi Natalie L. Lister David Pook Carmel J. Pezaro Shahneen Sandhu Shivakumar Keerthikumar Rosalia Quezada Urban Melissa Papargiris Jenna Kraska Heather B. Madsen Hong Wang Michelle G. Richards Birunthi Niranjan Samantha O’Dea Linda Teng William Wheelahan Zhuoer Li Nicholas Choo John F. Ouyang Heather Thorne Lisa Devereux Rodney J. Hicks Shomik Sengupta Laurence Harewood Mahesh Iddawala Arun A. Azad Jeremy Goad Jeremy Grummet John Kourambas Edmond M. Kwan Daniel Moon Declan G. Murphy John Pedersen David Clouston Sam Norden Andrew Ryan Luc Furic David L. Goode Mark Frydenberg Mitchell G. Lawrence Renea A. Taylor |
| author_sort |
Gail P. Risbridger |
| title |
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| title_short |
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| title_full |
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| title_fullStr |
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| title_full_unstemmed |
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| title_sort |
mural collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/72ce33db9321419ba5cb98782c40a1e1 |
| work_keys_str_mv |
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